The sequence stratigraphy of the middle Eocene-Pliocene of the Pannonian Basin permits to differentiate fifty-nine depositional sequences. An earlier compressional Paleogene basin in the central and eastern Pannonian Basin is unconformably overlain by a Neogene extensional basin. Tectonic regimes interacted with transgressive-regressive facies cycles. The boundaries of these cycles coincide with regional stage boundaries. Unconformities separating these cycles mark the episodic closure of connections between the Pannonian Basin and the European epicontinental seas from Oligocene through middle Miocene time. The unconformities are the result of short-term glacio-eustatic falls, sometimes enhanced by tectonic events. Within the limits of biostratigraphic resolution during the Eocene-middle Miocene, many of the sequences of the Pannonian Basin correlate well with the sequences proposed by Haq et al. (1987). However, eight sequences, i.e. one in the Lutetian, three in the Bartonian, one in the Priabonian, one in the Rupelian and two in the Burdigalian, were not identified by Haq et al. (1987). The sequences and their boundaries are directly correlated with global oxygen isotope events. Glacioeustasy generates sequence boundaries beginning as early as the middle Eocene. Within the lacustrine setting of the Pannonian Basin (late Miocene- Pliocene time) relative lake level changes appear to control the overall sequence development. However, other minor variables, the sediment supply and the topography of the initial depositional surface were additional controlling factors. Thus differences in the physiography of the basin lead to totally different sequence types that all reflect to lake level fluctuations. In lateral direction, during a short time period, these lacustrine sequences are more sensitive to changes in the initial depositional profile and sediment supply. / pages 390 and 396 are missing from text.