Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Includes bibliographical references (p. 137-161).

Thesis (Ph. D.)--University of California, Irvine, 2005. / Includes bibliographical references (leaves 119-125). Also available online (PDF file) by a subscription to the set or by purchasing the individual file.

Thesis (Ph. D.)--University of California, Irvine, 2005. / Includes bibliographical references (leaves 119-125).

Thesis (Ph. D.)--Drexel University, 2006. / Includes abstract and vita. Includes bibliographical references (leaves 170-193).

Dissertation submitted in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Durban University of Technology, 2008. / To compare trunk flexion and lateral flexion range of motion (ROM) pre-post intervention. To compare the bowling speed of Action Cricket fast bowlers pre-post intervention. To determine the correlation between change in bowling speed immediately post-intervention to change in trunk flexion and lateral flexion ROM immediately post-intervention. To determine the association between change in bowling speed immediately post-intervention and the subjects’ perception of change in bowling speed. Methods: Forty asymptomatic Action Cricket fast bowlers were divided into four groups of ten each. Group 1 received lumbar spine manipulation, Group 2 received thoracic spine manipulation, Group 3 received combined thoracic and lumbar spine manipulation and Group 4 received the sham laser intervention (placebo). Pre- and post-intervention trunk flexion and lateral flexion ROM and bowling speed were measured using a digital inclinometer and a SpeedTracTM Speed Sport Radar. The subjects’ perception of a change in bowling speed post-intervention was also recorded. SPSS version 15.0 was used to analyse the data. Two-tailed tests were used in all cases. Results: Trunk flexion and lateral flexion increased significantly (p < 0.05) post-spinal manipulation. There was a significant increase in bowling speed post-thoracic (p = 0.042) and post-combined manipulation (p < 0.000). A significant yet weak positive correlation (p = 0.003; r = 0.451) was seen in change in bowling speed and change in thoracic flexion and lateral flexion. There was no significant difference in the percentage subjective change by intervention group (p = 0.217). Conclusions: Spinal manipulation is a valid intervention for short-term increase in bowling speed. / National Research Fund

This PhD thesis explores the phenomenon of resilience in people with spinal cord injury (SCI). The purpose of this research is to understand how resilience is experienced and given meaning in people with SCI, as well how resilience is fostered, how it impacts upon health and well-being, and how it can be managed to achieve maximum benefits with regard to health and well-being. It is the first in depth narrative investigation of resilience in people with SCI. Using both life story interviews and the process of timelining, participants stories were collected. Following this they were then analysed using dialogical narrative analysis (Frank, 2010, 2012). This enabled participants stories to be examined with regard to their effects on resilience and health and well-being. The analysis shows that firstly, due to the intangible nature of resilience, participants had trouble in articulating exactly what resilience meant to them. Instead, resilience was shown through participants stories which could be grouped into four different narrative types: loss, adaptation, posttraumatic growth (PTG), and life-as-normal. Together, these narrative types constructed resilience, and as such, resilience in people with SCI has four facets or faces , like a four-sided dice. The process of resilience in people with SCI worked by participants drawing upon the different narrative types at different times depending upon the demands being placed upon them. The loss narrative was drawn upon immediately following injury, and was concerned with the narration of the physical, psychological and social losses participants incurred following SCI. The loss narrative fostered resilience by enabling participants to talk about their losses, enabling participants to survive the hardest time of their lives. The second narrative type was the adaptation narrative. This narrative type focussed upon rehabilitation in both the spinal unit and in the community. This narrative type built resilience via progression through rehabilitation towards a quality of life comparable to pre-injury levels. The PTG narrative was concerned with the ways in which participants had developed following SCI and built resilience by shifting the focus onto the positives to come out of participants experiences of SCI. The life-as-normal narrative was used by two participants across their entire life story and enabled participants to continue with their lives with minimal disruption. It built resilience by placing disability in the background and therefore making it unimportant. This thesis then concludes with the empirical, theoretical, methodological and practical implications arising from this research. The potential for resilience to help improve the health and well-being of people with SCI is discussed, as well as the ways in which resilience can have a maximum benefit on health and well-being of people with SCI.

Thesis (M.S.O.T.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / PURPOSE: Past research has shown discrepancy between parent and child report of health-related outcomes, leading to questions regarding the use of parents as proxy reporters for their children. It is not known whether similar discrepancies exist between child and parent views of the child’s participation following spinal cord injury. It is also unclear how perception of participation in youth after spinal cord injury compares to self-perception of participation for youth without disabilities. The current study investigated these questions. PROCEDURE: A secondary analysis was completed on data collected from children and youth with a spinal cord injury ages 8-21 years (n=381) and their parents using the Shriner’s Participation Scale. The young person’s self-perception ratings of participation were compared to his/her parent’s perception of their participation, and patterns of self-perception of participation among peers without disabilities . ICC’s were conducted to determine levels of consistency among parent-child dyad responses. Responses from a sample of children and youth without disabilities (n=2005) were compared by t-test to those of the youth with a spinal cord injury determine whether there were differences in how often each group reported they are unable to participate in certain activities. SUMMARY OF FINDINGS: Overall low levels of agreement were found between parent and child perceptions of the child’s participation. The highest agreement (average ICC) between parent and child was found in the 14-17 year old age group. There was a significant difference in self-perception of ability to participate in certain activities between the youth with spinal cord injury and their peers without disabilities. / 2031-01-01

The lamprey is a basal vertebrate that achieves spontaneous functional recovery after complete spinal cord transection over a stereotypical period of 12 weeks. Despite anatomical, physiological, and behavioral data on spinal cord regeneration in lamprey, the molecular mechanisms underlying this capacity are largely unknown. In this study, next generation RNA-sequencing (RNA-Seq) of the brain and injury site within the spinal cord was used to determine and compare transcriptional profiles of uninjured and recovered lampreys at 12 weeks after spinal cord injury (SCI), when normal swimming behavior is achieved. The objective of this study was to determine if recovered animals had a significantly different transcriptional program than uninjured animals. Significant differences in gene expression were observed, with 1468 and 1033 differentially expressed genes in the spinal cord and brain respectively. Leveraging functional data for mammalian homologs of differentially expressed genes, several conserved transcription factors and molecular pathways in both uninjured and injured animals were identified. Gene expression patterns associated with functional recovery in lampreys may be useful in guiding studies aimed at modulating mammalian responses to spinal cord injury, and promoting functional recovery in species with less spontaneous regenerative potential. / 2019-07-11T00:00:00Z

Le SNC est doté de faibles capacités régénératives intrinsèques. Ses lésions se traduisent par l’apparition d’incapacités irréversibles invalidantes. Les traumas spinaux cervicaux (C1-C2) représentent la majorité des cas. Ils détruisent, les voies bulbo-spinales respiratoires interrompant ainsi les connexions synaptiques entre les pré-motoneurones et le pool de motoneurones phréniques causant un dysfonctionnement diaphragmatique. Ces lésions atteignent aussi les voies pyramidales commandant les neurones moteurs situés dans l'élargissement cervical qui innervent les extrémités supérieures impliquées dans les fonctions motrices, Les symptômes respiratoires consistent en une capacité vitale réduite et des infections pulmonaires. Les symptômes musculo-squelettiques comprennent la paraplégie, l'hémiplégie, l'hémiparésie, la tétraplégie. Peu d'études sont consacrées à l’évaluation du potentiel thérapeutique des cellules souches ecto-mésenchymateuses olfactives (OEMSCs) dans des modèles lésionnels chez les rongeurs. Celui-ci a été évalué sur notre modèle lésionnel compressif en C2 qui induit un déficit respiratoire et locomoteur persistant, reproductible et quantifiable. Elles présentent de fortes capacités prolifératives et neurogéniques et ne présentent aucun facteur co-morbide. Ces rats syngéniques nous ont permis d’évaluer la faisabilité, d’éviter l’utilisation d’anti rejet et de permettre une bonne intégration des OEMSCs dans le tissu hôte. Leur transplantation facilite une récupération substantielle des fonctions respiratoires et locomotrice, réduit la zone lésionnelle et l'inflammation et favorise l’axogénèse suite à une lésion cervicale en C2. / The CNS has weak intrinsic regenerative capabilities. Its lesions result in the appearance of irreversible incapacitating disabilities. Cervical spinal trauma (C1-C2) represents the majority of cases. They destroy the bulbo-spinal respiratory tract thus interrupting the synaptic connections between the pre-motoneurons and the phrenic motor neuron pool causing diaphragmatic dysfunction. These lesions also reach the pyramidal pathways controlling the motor neurons located in cervical enlargement that innervate the upper extremities involved in the motor functions. Respiratory symptoms consist of a reduced vital capacity and pulmonary infections. Musculoskeletal symptoms include paraplegia, hemiplegia, hemiparesis, quadriplegia. Few studies are devoted to assessing the therapeutic potential of olfactory ecto-mesenchymal stem cells (OEMSCs) in rodent models of injury. This one was evaluated on our model compressive lesion in C2 which induces respiratory and locomotor deficit persistent, reproducible and quantifiable. They have high proliferative and neurogenic capacities and have no co-morbid factor. The choice of a syngeneic strain allowed us to evaluate the feasibility, to avoid the use of anti rejection and thus to allow an integration of the OEMSCs in the host tissue. The transplantation of OEMSCs facilitates a substantial recovery of respiratory and locomotor functions, reduces lesion area and inflammation, and promotes axogenesis following cervical spinal cord injury in C2.

Dissertation submitted in partial compliance with the requirements for a Master's Degree in Technology: Chiropractic, at Technikon Natal, 1999. / The purpose of this investigation was to compare the relative effect of spinal manipulation as opposed to acupuncture treatment in order to determine a more effective approach in the treatment of chronic sinusitis. It was hypothesized that chiropractic treatment and acupuncture treatment would both be effective in the treatment of chronic sinusitis. However, it was proposed that the chiropractic treatment would be more effective than acupuncture treatment / M