Thesis (degree.)--Marshall University, 2009. / Title from document title page. Includes abstract. Document formatted into pages: contains 57 p. Includes bibliographical references p. 51-57.

Thesis (M.A.)--Catholic Theological Union at Chicago, 2007. / Vita. Includes bibliographical references (leaves 42-47).

Thesis (M.A.)--Catholic Theological Union at Chicago, 2007. / Vita. Includes bibliographical references (leaves 42-47).

archives@tulane.edu / I would like to thank the Tulane Department of Biomedical Engineering and the Tulane Center for Stem Cell Research and Regenerative Medicine for the support and means to conduct such meaningful research. I am also thankful for the continued support and encouragement from Dr. Bruce Bunnell, whose enthusiasm and inexhaustible drive is a source of inspiration. To my fellow lab members, and particularly Ben O’Donnell, I attribute the technical skills I have learned and the joy of coming to work every day in such a welcoming environment. I am grateful for the additional help from our cohort of research assistants, including Tia Monjure, Brooke Santagato, Michael L’Ecuyer, and Mitchell Couldwell. Additionally, much of my work is in part attributed to the team of specialized core personnel, Alan Tucker in flow cytometry and Dina Gaupp in histology. I am grateful for the American Association of University Women which provided funding for my master’s coursework. In affiliation with the University and Pittsburgh and Stanford University, this project is the collaborative effort of many great minds. It was financially supported by the National Institute of Health under the project number 1UG3TR002136-01. / 1 / Clara Ives

No description available.

Neural stem cells are capable of self-renewal and multilineage differentiation into the main cell types of the central nervous system, which are the neurons, astrocytes, and oligodendrocytes. These properties make neural stem cells an attractive cell source for potential cell-based therapies; however, thoroughly describing their gene expression programs is required to predict their safety and efficacy. In this study, we reveal that mouse embryonic day (E14) forebrain-derived primary neural stem cells have an astrocytic gene expression profile. We show that the NOTCH and BMP signalling pathways exhibit transcription profiles that are specific to the proliferation and differentiation of this neural stem cell source. Finally, we report the expression patterns of the Hox and TALE family homeobox genes in the E14 forebrain, E14 forebrain-derived primary neural stem cells, and their differentiating progeny. Protein expression analysis suggests that PREP2 is involved in neural stem cell proliferation and neuronogenesis, and that MEIS1 is involved in astrocyte differentiation. This is the first report on the expression patterns of TALE genes in forebrain-derived NSC differentiated in vitro, which provides a starting point to investigate the role of TALE genes in forebrain neurogenesis.

No description available.

Neural stem cells are capable of self-renewal and multilineage differentiation into the main cell types of the central nervous system, which are the neurons, astrocytes, and oligodendrocytes. These properties make neural stem cells an attractive cell source for potential cell-based therapies; however, thoroughly describing their gene expression programs is required to predict their safety and efficacy. In this study, we reveal that mouse embryonic day (E14) forebrain-derived primary neural stem cells have an astrocytic gene expression profile. We show that the NOTCH and BMP signalling pathways exhibit transcription profiles that are specific to the proliferation and differentiation of this neural stem cell source. Finally, we report the expression patterns of the Hox and TALE family homeobox genes in the E14 forebrain, E14 forebrain-derived primary neural stem cells, and their differentiating progeny. Protein expression analysis suggests that PREP2 is involved in neural stem cell proliferation and neuronogenesis, and that MEIS1 is involved in astrocyte differentiation. This is the first report on the expression patterns of TALE genes in forebrain-derived NSC differentiated in vitro, which provides a starting point to investigate the role of TALE genes in forebrain neurogenesis.

Thesis (M.S.) in Teaching--University of Maine, 2007. / Includes vita. Includes bibliographical references (leaves 63-64).

No description available.