No description available.

Sammanfattning Syfte: Syftet med denna systematiska litteraturöversikt var att testa hypotesen att det inte är någon skillnad rörande lyckandefrekvensen gällande implantatbehandling vid sinuslyft med olika bentransplantatmaterial Material och metod: Studien baseras på sökningar i PubMed, Cochrane Library och Web of Science i kombination med en manuell granskning av relevanta publikationer. Inkluderade publikationer var prospektiva studier av ≥ 10 patienter och med en uppföljningstid på ≥ 1 år. Autologt bentransplantat från mandibel/maxilla, oorganiskt ben (Bio-Oss), en kombination av dessa två samt sinuslyft utan insättning av bentransplant utvärderades. Kvaliteten på varje publikation bedömas enligt kriterier baserade på en modifiering av STROBE-statment. Resultat: Sökningen resulterade i 818 titlar och 15 inkluderade publikationer relevanta enligt förutbestämda inklusionskriterier. En studie var en randomiserad kontrollerad studie (RCT) och en var en kontrollerad klinisk studie (CCT). De återstående 13 studierna var observationsstudier. Uppföljningen varierade mellan ett och nio år, och antalet patienter mellan 10 och 191. Sinuslyft utan insättning av bentransplantat hade en implantatöverlevnad på 97,7% -100% och studier rörande autologt bentransplantat 98,8%. Bio-Oss resulterade i 86,3% -98,1% överlevnad och en kombination av Bio-Oss och autologt ben resulterade i en överlevnad på 90,7%. Slutsats: Enligt denna undersökning fanns ingen skillnad i implantat överlevnad mellan de olika bentransplantaten. Beroende på studiernas karaktär behövs fler RCT och CCT studier, som analyserar implantatutfallet, involverar sinuslyft och olika bentransplantat rörande implantatöverlevnad och lyckandefrekvens. / AbstractAims: The objective was to test the hypothesis that there is no difference in implant treatment outcome using different bone graft material for sinus floor augmentation.Material and methods: This systematic review is based on searches in PubMed, the Cochrane Library and the Web of Science and a hand search of relevant publications. Autologous bone, anorganic bovine bone (Bio-Oss), a combination of these two and elevation of the Schneiderian membrane with no graft material was evaluated. The quality of each publication was assessed according to criteria based on the STROBE-statements.Results: The search provided 818 titles and 15 were found relevant according to the predetermined inclusion criteria. One study was a randomized controlled trial (RCT) and one was a controlled clinical trial (CCT). The remaining 13 studies were observation studies. The follow-up time varied between one and nine years and the number of patients between 10 and 191. Studies on elevation of the Schneiderian membrane with no bone graft material reported an implant survival rate between 97.7% and100% and studies on only autologous bone graft material 98.8%. Bio-Oss as bone graft material resulted in 86.3%-98.1% survival rate and a combination of Bio-Oss and autologous bone graft resulted in a survival rate of 90.7%.Conclusion: There was no difference in implant outcome of the different bone graft material. More studies designed as RCT and CCT, which analyze the implant outcome involving sinus floor augmentation and different bone graft material are needed to improve evidence on survival and success rate.

Bei der Behandlung der idiopathischen Adoleszentenskoliose werden für die Spondylodese verschiedene Knochenmaterialien verwendet. Das autologe Knochenmaterial wird als der „Goldstandard“ bezeichnet. Da größere Mengen von Knochenmaterial für die Spondylodese nötig sind, erfolgt die Entnahme des autologen Knochens oft auch vom Beckenkamm. Dies kann zu erheblichen Komplikationen führen. Bei der Verwendung von allogenem Material besteht immer die Gefahr der viralen und bakteriellen Kontamination. Aufgrund dieser Probleme besteht ein Interesse an kompatiblen und osteokonduktiven Knochenersatzmaterialien. In dieser Studie soll untersucht werden, ob mit dem Knochenersatzmaterial beta-Tricalciumphosphat in Granulatform eine spinale Fusion erreicht werden kann. Dazu wurden 28 Patienten mit idiopathischer Adoleszentenskoliose nach der Methode von Cotrel-Dubousset operiert. Für die dorsale Spondylodese wurde bei 19 Patienten eine Mischung aus autologem/allogenem Knochen verwendet. 9 Patienten erhielten eine Mischung aus autologem Knochen und 25 g beta-Tricalciumphosphat in Granulatform. Als Verlaufskontrolle wurden zu verschiedenen Zeitpunkten klinische Untersuchungen durchgeführt und Röntgenbilder angefertigt. Zur Beurteilung der Knochendichte wurde bei allen Patienten nach ca. 11 Monaten eine Computertomographie durchgeführt. Eine Fusion der Segmente war bei beiden Gruppen anhand der Röntgenbilder nach ca. 6 Monaten vorhanden. Keine Pseudarthrosen wurden beobachtet. Die Knochendichte war durchschnittlich 430 mg/cm³ in der TCP Gruppe und 337 mg/cm³ in der Knochengruppe. Nach ca. 8 Monaten war das TCP auf den Röntgenbilder nicht mehr nachweisbar. Nach den Ergebnissen zu urteilen, ist beta-Tricalciumphosphat eine gute Alternative bei der operativen Behandlung der idiopathischen Adoleszentenskoliose, mit der ähnliche spinale Fusionsraten, wie mit autologem/allogenem Knochen erreicht werden können, besonders, wenn große Mengen an Knochen benötigt werden. / For correction of idiopathic adolescent scoliosis different bone materials are used to achieve spinal fusion. Autograft bone is known as the gold standard. Mostly large quantities of bone materials are needed for spinal fusion. Autograft bone is often taken from the iliac crest which can lead to severe problems. Using allografts there is always a risk of viral or bacterial contamination. Due to these problems the interest in compatible and osteconductive bone materials is rising. The aim of this study is to evaluate the ability of beta-tricalciumphosphat in granular form to achieve dorsal spondylodesis in adolescent idiopathic scoliosis. 28 patients underwent surgical correction by the method of Cotrel-Dubousset. Posterolateral grafting was performed using autograft/allograft bone for 29 patients and a mixture of autograft bone and 25 g of beta-tricalciumphosphate for 9 patients. As a follow-up clinical examination and X-rays were done at several dates. To measure the bone density CT-scans were taken about 11 month after surgery. According to the radiographs a solid fusion was shown after approximately 6 month in both groups. No pseudarthrosis was observed. Bone mineral density was about 430 mg/cm³ in the TCP group and 337 mg/cm³ in the bone group. After approximately 8 month the TCP was unverifiable in the X-rays. Based on the results of this study beta-tricalciumphosphate can be seen as an alternative in the surgical correction of idiopathic adolescent scoliosis. Similar spinal fusion rates compared with the use of autograft/allograft bone can be achieved, especially when huge quantities of bone are needed.

Thesis (MScEng) -- Stellenbosch University, 2014. / ENGLISH ABSTRACT: In this study, commercially pure titanium foam was produced using space holder powder metallurgy techniques. Titanium foam is attractive as a scaffolding material for bone replacement and implants in the body. The porous morphology of the foam promotes osteogenesis, while the mechanical behaviour of the foam is closer to that of bone, which has an elastic moduli range of 5 - 40 GPa. Titanium foam was manufactured from powder mixtures of commercially pure titanium (CPTi) powder mixed with 41.4 wt% ammonium bicarbonate (ABC) powder and 1.45 wt% polyethyl glycol (PEG) powder. In this study, two CPTi powders with different particle size distributions, < 75 μm (-200 mesh, designated TiAA) and < 200 μm (-100 mesh, designated TiG), were mixed with the space holder ABC powder, that had been sieved into specified particle size ranges. The size ranges of space holder material studied were: 0 - 710, 250 - 425, 425 - 560, and 560 - 710 μm. This allowed foams with different large or macropore distributions to be produced from the different mixtures. The mixtures were uniaxially compacted at 100 MPa into transverse rupture bars. The ABC and PEG was then removed by thermal debinding in air for 5 hours at 100 °C and 1 hour at 330 °C each, consecutively. The debound samples are then sintered under high (10-6 mbar) vacuum on yttria-stabilised zirconia substrates, heating at 5 °C/min to 1200 °C, with a 2 hour hold at temperature. The microstructures of the different foams were evaluated by examining the polished samples using light optical microscopy. Three point bend tests were conducted on the sintered bars in order to determine the flexural strength and flexural modulus of the different foams. The produced foams had a relative density range between 37.5 - 62.5 % and average macro pore size range between 300 - 500 μm. The foams were found to have an elastic modulus similar to that of bone, 2 - 7 GPa. Finally, the mechanical properties of the foams were compared to known open foam mechanical models and other research projects. It was found that: (i) changes in either metal or space holder powder influences the sintering behaviour of metal foams, (ii) sintered titanium foams with similar densities but different macro/micropore size distributions have different mechanical responses to stress and (iii) the Ashby-Gibson model, based on foam density alone, gives a rough estimate of mechanical properties for the titanium foams studied, but does not capture variations due to pore size distribution. / AFRIKAANSE OPSOMMING: In hierdie studie is kommersiële suiwer titaanskuim geproduseer met behulp van ruimtehouer poeier metallurgie tegnieke. Titaanskuim is aantreklik as 'n raamwerkmateriaal vir beenvervanging en -inplantings in die liggaam. Die poreuse morfologie van die skuim bevorder osteogenese, terwyl die meganiese gedrag van die skuim naby aan dié van been is, met ‘n elasticiteitsmodulus tussen 5 - 40 GPa. Titaanskuim is vervaardig van ‘n poeier mengsel van kommersiële suiwer titaan (CPTi) poeier gemeng met 41,4 gew% ammonium bikarbonaat (ABC) poeier en 1.45 gew% poli-etileenglikol (PEG) poeier. In hierdie studie is twee tipes CPTi poeiers met verskillende deeltjiegrootteverspreiding, < 75 μm (-200 stofdigtheid, TiAA genoem) en <200 μm (-100 stofdigtheid, TiG genoem), met die ruimtehouer ABC-poeier, wat in bepaalde deeltjiegroottereekse gesif is, gemeng. Die wisselende groottes van ruimtehouer wat bestudeer is, was: 0 - 710, 250 - 425, 425 - 560, 560 - 710 μm. Dit het die vervaardiging van skuim met verskillende groot of macroporeuse vanaf die verskillende mengsels toegelaat. Die mengsel is teen 100 MPa in een rigting gekompakteer. Die ABC en PEG is dan verwyder word deur termiese ontbinding in lug vir 5 uur by 100 °C en 1 uur by 330 °C elk, onderskeidelik. Die ontbinde monsters is dan onder hoë (10-6 mbar) leemte op yttrium-gestabiliseer zirconia-substraat, met verwarming teen 5 °C/min tot 1200 °C met 'n verdere 2 uur by 1200 °C, gesinterd. Die mikrostrukture van die verskillende skuim is geëvalueer deur gepoleerde monsters met behulp van ‘n ligmikroskopie te ondersoek . Driepunt draaitoetse is op die gesinterd stawe uitgevoer om die buigsterkte en buigmodulus van die verskillende skuime te bepaal. Die vervaardigde skuime se relatiewe digtheid het tussen 37,5 - 62,5 % gewissel en die gemiddelde makroporiegrootte tussen 300 - 500 μm gewissel. Die skuim het 'n elastisiteitsmodulus soortgelyk aan dié van been getoon, 2 – 7 GPa. Ten slotte is die meganiese eienskappe van die skuim met bekende oop skuim meganiese modelle en ander navorsingsprojekte vergelyk. Daar is bevind dat: (i) veranderinge in óf metaal of ruimtehouer poeier beïnvloed die sinteringgedrag van metaalskuime, (ii) gesinterd titaniumskuim met soortgelyke digthede, maar verskillende makro / mikroporeuse verdelings, toon verskillende meganiese reaksies op stres en die Ashby-Gibson model, gebaseer op die skuimdigtheid alleen, (iii) wat 'n rowwe skatting van die meganiese eienskappe vir die bestudeerde titaniumskuime gee, maar nie die variasies ingrootteverspreiding van porieë ondervang nie.

Natural composites, in particular nacre, often combine high strength and toughness thanks to highly ordered architectures and controlled geometries of the reinforcement components. However, combining strength, toughness and resorbability in synthetic materials remains a challenge in particular in the field of bone graft substitutes. In the present study, calcium phosphate-(CaP-)based materials with designed architectures inspired from natural composite materials were achieved. CaP platelets obtained by precipitation in organic medium were first aligned in chitosan matrices by solvent casting in ambient conditions. Efficient strengthening was obtained with 15 vol-% ceramic, reaching cortical bone strength (150 MPa) and preserving good ductility (5 % deformation). In a weak magnetic field, high spatial arrangement without percolation was maintained up to 20 vol-%. With directional freezing, good alignment of the platelets could be pushed up to 50 vol-%. In parallel, in situ recrystallization of CaP blocks in hydrothermal conditions led to hierarchical structures. The strength and the work-of-fracture were enhanced (300%) thanks to a change of failure mode.

No description available.

La substitution ionique apparait comme une des possibilités pour moduler la bioactivité de l’hydroxyapatite (HA), matériau couramment employé comme substitut osseux. L’incorporation simultanée d’ions carbonates et silicates dans la structure apatitique pourrait permettre de coupler les propriétés de résorption et de dissolution des apatites carbonatées avec le rôle métabolique important du silicium dans le tissu conjonctif.Des poudres d'hydroxyapatites phosphocalciques substituées en carbonates et en silicates de formule Ca10 x+y(PO4)6-x-y(CO3)x(SiO4)y(OH)2-x+y (avec 0 ≤ y ≤ x ≤ 2 et x+y ≤ 2, C Si HA), ont été synthétisées par précipitation en milieu aqueux. L’originalité de cette synthèse réside essentiellement dans l’emploi de réactifs parfaitement solubles et miscibles dans l’eau. L’incorporation des carbonates et des silicates en substitution des phosphates a lieu dès la précipitation. Les poudres obtenues sont monophasiques, cristallines et de structure apatitique.Les caractérisations physico-chimiques des poudres ont mis en évidence l’existence d’interactions entre les carbonates (A et B) et les silicates au sein de la maille apatitique. La décarbonatation des sites B, synonyme de décomposition de la phase C-Si-HA, a pu être décalée à de plus hautes températures avec l’emploi du CO2 comme atmosphère de calcination. Le frittage de céramiques denses et monophasiques en C Si HA destinée à une première évaluation biologique a donc été possible. La culture in vitro de cellules souches mésenchymateuses C3H10T1/2 à la surface de céramiques de composition C0,8 Si0,4 HA a mis en évidence leur biocompatibilité et des propriétés ostéoconductives équivalentes à celles de l’HA. / Ionic substitution appears as one possibility to modulate the bioactivity of hydroxyapatite (HA), which is a material commonly used as bone substitute due to its chemical and crystallographic similarities with bone mineral part. The simultaneous incorporation of silicates and carbonate ions in the apatite structure could allow coupling the resorption and dissolution properties of carbonate apatite with the important metabolic role of silicon in the connective tissue.Co-substituted hydroxyapatite powders, of assumed composition Ca10 x+y(PO4)6-x-y(CO3)x(SiO4)y(OH)2-x+y (with 0 ≤ y ≤ x ≤ 2 et x+y ≤ 2, C Si HA), with controlled amount of carbonate (x) and silicate groups (y), were synthesized by means of a wet precipitation method. The innovative character of this synthesis process lies in the use of completely soluble and miscible reagents in water. According to this method, silicates and carbonates substitution for phosphate ions into the apatitic structure occurs from precipitation. The powders obtained are monophasic, crystalline and apatitic.The physicochemical characterizations of powders revealed the existence of interactions between carbonates (A and B) and silicates within the apatitic structure. C Si HA phase decomposes when B-type carbonate are released from the structure. The use of CO2 throughout the heat treatment allows to shift the B sites decarbonatation to higher temperature than under inert atmosphere. The sintering of dense and monophasic ceramic in C Si HA was realized. In vitro culture of mesenchymal stem cells C3H10T1/2 on the surface ceramics showed equivalent biocompatibility and osteoconductive properties between HA and C-Si-HA (x=0.8, y=0.4) phases.

Bakgrund: Taximarknaden har varit, och är, under förändring. Till följd av den teknologiska utvecklingen har nya aktörer och substitut etablerat sig på marknaden. Uber, Bzzt och Lime är endast tre av de företag som vuxit fram under de senare åren. De nya företagen bidrar inte endast med nya, innovativa substitut till traditionell taxi, utan även ökad konkurrens vad gäller tillgänglighet via digitala plattformar. Syfte: Syftet med uppsatsen är att analysera den teknologiska utvecklingens betydelse för taximarknadens struktur och funktion, med fokus på Stockholm. Metod: Uppsatsens referensram är Structure-Conduct-Performance modellen. För djupare analys och förståelse har intervjuer med: Bzzt, Svenska Taxiförbundet och Taxi Stockholm, genomförts. Uppsatsen innefattar även två egna undersökningar om taxiföretagens prisnivå och tillgänglighet. De taxiföretagen som inkluderas i uppsatsen är: Sverigetaxi, TaxiKurir, Taxi Stockholm, TOPCAB samt Uber. Slutsats: Den teknologiska utvecklingen har en stor betydelse för taximarknadens struktur och funktion, i det avseende att den bidrar till en mer kundcentrerad och effektivare marknad. Marknadsstrukturen i Stockholm liknar en hybridmarknad mellan oligopol och fullständig konkurrens, beroende på de storleksmässiga skillnader som finns mellan aktörerna. Marknaden har en jämn prisnivå och bra tillgänglighet, varav det sistnämnda har förbättrats till följd av utvecklandet av taxiföretagens egna applikationer. / Background: The taxi market has been, and is, undergoing a transformation. As a result of the technological development, new companies and substitutes have been established on the market. Uber, Bzzt and Lime are only three of all the new companies that have emerged in the recent years, and not only contribute with new, innovative substitutes for traditional taxi, but also increased competition in terms of accessibility through digital platforms. Purpose: The purpose of the essay is to analyze the influence of the technological development on the taxi market’s structure and function, with focus on Stockholm. Completion: The main framework of the essay is the Structure-Conduct-Performance model. For a more profound analysis three interviews were conducted with: Bzzt, Svenska Taxiförbundet and Taxi Stockholm. The essay also includes a study of the price level and a study of the accessibility to a taxi. The included companies are: Sverigetaxi, TaxiKurir, Taxi Stockholm, TOPCAB and Uber. Conclusions: The technological development have a large impact on the structure and function of the taxi market, since it contributes to a more customer-centered and efficient market. The market structure in Stockholm is similar to a hybrid market of an oligopoly and perfect competition, depending on the difference in size of the existing companies. The market has a uniform price level and a good accessibility, of which the latest has improved as a result of the development of the taxi companies own applications.

A utilização de osteoindutores como a proteína morfogenética óssea recombinante humana tipo 2 (rhBMP-2) em cirurgia oral e maxilofacial para reparação e regeneração óssea tem aumentado progressivamente. Porém, suas indicações ainda estão limitadas a preenchimento de cavidades e pequenas reconstruções. Este estudo teve como objetivo analisar e comparar, por meio da microtomografia computadorizada tridimensional (Micro-TC 3D) e histomorfometria, a arquitetura óssea, a taxa de osso neoformado e a taxa de biodegradação do -Tricálcio Fostato (-TCP), Fosfato de Cálcio Bifásico (BCP) e Osso Mineral Bovino (BBM), utilizados como carreadores adicionais à rhBMP-2/esponja de colágeno (ACS) em um modelo de regeneração óssea guiada (ROG) vertical em calvária de coelhos. Quatro cilindros de titânio foram fixados à calvária de 20 coelhos da raça Nova Zelândia. No Grupo 1 (n = 10), 3 cilindros foram aleatoriamente preenchidos com um dos materiais teste utilizados como carreadores e um cilindro foi preenchido com coágulo sanguíneo (CO). No Grupo 2 (n = 10), os cilindros foram aleatoriamente designados para os mesmos materiais e coágulo sanguíneo, com a adição da rhBMP-2/ACS. Após 14 semanas de reparação, as amostras foram coletadas e enviadas para a aquisição de imagens da Micro-TC e processamento histológico. De acordo com a análise histomorfométrica, a área óssea média para o Grupo 2 (com rhBMP-2) foi maior do que no Grupo 1 (sem rhBMP-2) para os materiais BCP e -TCP (p <0,001). Não houve diferença entre os grupos para BBM e CO (p> 0,05). Em relação às taxas de reabsorção, a área média dos materiais remanescentes no Grupo 2 foi menor do que no Grupo 1 para todos os materiais (p <0,001) e BBM e -TCP obtiveram a maior taxa de reabsorção nos dois grupos (BBM = -TCP > BCP). A análise da micro-TC revelou que no Grupo 2, BCP e -TCP apresentaram maior volume ósseo médio (BV) do que no Grupo 1 (p <0,05). Não houve diferença entre os grupos para os materiais BBM e CO (p> 0,05). O volume médio de materiais restantes (MV) para o Grupo 2 foi menor do que no Grupo 1 para BBM e -TCP (p <0,05), sem diferença significante entre os grupos para BCP (p = 0,848). A análise dos parâmetros Fator Padrão Trabecular (Tb.Pf) e Índice de Modelo Estrutural (SMI) mostrou no Grupo 2 valores negativos para BCP e -TCP, indicando melhor interconectividade e presença de arquitetura trabecular mais achatada e côncava, indicadores de melhor qualidade e resistência óssea. Pelos resultados apresentados concluiu-se que a utilização da rhBMP-2/ACS associada aos materiais carreadores BCP (Fosfato de Cálcio Bifásico) e -TCP (-Fosfato Tricálcio) aumentou significativamente a formação óssea neste modelo de ROG em calvária de coelhos além de acelerar a biodegradação dos materiais BBM (Osso Mineral Bovino) e -TCP (-Fosfato Tricálcio) neste modelo de ROG. / The use of osteoinductors as the human recombinant bone morphogenetic protein 2 type 2 (rhBMP-2) in oral and maxillofacial surgery for bone regeneration and repair has progressively increased. However, indications are still limited to filling of cavities and small reconstructions. However, its indications are still limited to filling of cavities and small reconstructions. This study aimed to analyze and compare, by means of three-dimensional microtomography (Micro-CT 3D) and histomorphometry, the bone architecture, the rate of newly formed bone and the biodegradation rate of beta tricalcium phosphate (-TCP), biphasic calcium phosphate (BCP), and mineral bovine bone mineral (BBM) used as additional carriers to rhBMP-2/absorbable collagen sponge (ACS) in a vertical guided bone regeneration model (GBR) in rabbit calvarium. Four titanium cylinders were fixed to the calvarium of 22 New Zealand rabbits. In Group 1 (n = 10), 3 cylinders were randomly filled with one of the test materials and 1 cylinder was filled with a blood clot (CL). In Group 2 (n = 10), the cylinders were randomly assigned to the same materials and blood clot, with the addition of rhBMP-2. After 14 weeks of healing the samples were collected and sent to 3D Micro-CT image acquisition and histological processing. According to histomorphometric analysis, the mean bone area in Group 2 (with rhBMP-2) was greater than in Group 1 (without rhBMP-2) to materials BCP and -TCP (p<0.001). There was no difference between groups to BBM and CL (p>0.05). Regarding the resorption rates, the mean area of remaining materials in Group 2 was lower than in Group 1 to all materials (p<0.001) and BBM and -TCP had the greater resorption rate in both groups (BBM= -TCP >BCP). The Micro-CT analysis revealed that in Group 2, BCP and -TCP had greater mean bone volume (BV) than in Group 1 (p<0.05). There was no difference between groups to materials BBM and CL (p>0.05). The mean volume of remaining materials (MV) in Group 2 was lower than in Group 1 to BBM and -TCP (p<0.05). There was no difference between groups to BC (p=0.848). The analysis of the parameters Trabecular Pattern Factor (Tb.Pf) and Structure Model Índex (SMI), in Group 2 showed negative values for BCP and -TCP, indicating better interconnectivity and presence of more plate-like and trabecular architecture more flattened and concave, indicators of better quality and bone strength. By presented results it was concluded that the use of rhBMP-2/ACS associated with the carriers materials biphasic calcium phosphate (BCP) and beta tricalcium phosphate (-TCP) used as additional carriers, significantly increased bone formation in addition to accelerate the resorption of the materials BO (bovine bone mineral) and -TCP in this guided bone regeneration model in rabbit calvaria.

O presente trabalho teve como objetivo avaliar as características físico-químicas e de aceitação sensorial de diferentes produtos cárneos elaborados com adição de fibra de ervilha como substituto parcial de carne (visando redução de custos no produto) e de gordura (visando a elaboração de um produto mais saudável). Foram processados quatro diferentes produtos cárneos (nuggets, hambúrguer, apresuntado e salsicha), onde cada um apresentou as seguintes formulações: nuggets (Nuggets Controle (NC) - formulação semelhante à comercial, Nuggets Fibra/ Menos Carne (NFMC) - redução de 10% de carne e adição de 2 % de fibra de ervilha e Nuggets Fibra/ Menos Gordura (NFMG) - redução de 10 % de gordura e adição de 2% de fibra de ervilha), hambúrguer (Hambúrguer Controle (HC) - semelhante à formulação comercial; Hambúrguer Fibra/ Menos Carne (HFMC) - redução de 5% de carne e adição de 1 % de fibra de ervilha e Hambúrguer Fibra/ Menos Gordura (FMG) - redução de 7 % de gordura e adição de 1,0 % de fibra de ervilha), apresuntado (Apresuntado Controle (AC) - semelhante à formulação comercial e Apresuntado Fibra/Menos Carne (AFMC) - redução de 5% de carne e adição de 1% de fibra) e salsicha: (Salsicha Controle (SC) - semelhante à formulação comercial; Salsicha Fibra/Menos Carne (SFMC): redução de 5% de carne bovina e adição de 2% de fibra de ervilha e Salsicha Fibra/ Menos Gordura (SFMG) - redução de 7 % de gordura e adição de 2,0 % de fibra de ervilha). Após o processamento os produtos foram caracterizados quanto à composição centesimal, cor objetiva, perfil de textura, perda de peso após a fritura (nuggets), perda de peso por cocção (hambúrguer), redução do diâmetro (hambúrguer), perdas por gotejamento (apresuntado), rendimento do produto (salsicha), estabilidade da emulsão (salsicha) e avaliação sensorial (teste de aceitação com escala hedônica de nove pontos). Para os nuggets as formulações NFMC e NFMG apresentaram pH superior (p&lt;0,05) ao controle, e a formulação NFMG apresentou maior (p&lt;0,05) dureza, quanto à porcentagem de perdas após a fritura, os parâmetros elasticidade e coesividade e a avaliação sensorial não foram encontradas diferenças (p&gt;0,05) entre as formulações. A aplicação de fibra de ervilha e redução de carne e gordura nos hambúrgueres não afetaram (p&gt;0,05) os valor de pH, parâmetros de cor L* e b*, os parâmetros avaliados no perfil de textura, perdas de peso por cocção, redução do tamanho (encolhimento) e avaliação sensorial, apenas a formulação HFMC apresentou redução (p&lt;0,05) no parâmetro a*. Quanto ao apresuntado, os parâmetros de dureza e mastigabilidade foram maiores (p&lt;0,05) para a formulação AC, a formulação AFMC apresentou valor de L* superior (p&lt;0,05), parâmetros de cor a* e b* inferiores (p&lt;0,05) ao C e maior aceitação geral, já o valores de pH, perdas por gotejamento e as médias dos demais atributos sensoriais avaliados não apresentaram diferença (p&gt;0,05) entre as formulações. Em relação aos resultados obtidos na salsicha, a formulação SFMG apresentou pH inferior (p&lt;0,05) a SC e maior valor para os parâmetros de dureza e mastigabilidade. As formulações SFMC e SFMG apresentaram rendimento inferior (p&lt;0,05) a SC e não diferiram quanto à estabilidade da emulsão, já em relação a avaliação sensorial formulação SFMC apresentou notas superiores (p&lt;0,05) à formulação SC e SFMG quanto aos atributos textura, sabor e aceitabilidade geral. De acordo com os resultados obtidos pode-se concluir que a fibra de ervilha mostrou-se como um ingrediente promissor para aplicação em produtos cárneos, já que nas condições testadas a substituição parcial de carne e gordura por fibra de ervilha não ocasionou prejuízo na maioria dos parâmetros físico-químicos avaliados e não prejudicou a aceitação sensorial em nenhum dos produtos cárneos estudados. / The objective of this study was to characterize physicochemical aspects of meat products and their sensorial acceptance elaborated with the addition of pea fiber as a partial substitute of meat (aiming the product cost reduction), and fat (aiming a healthier product). Four different meat products were formulated and processed (chicken nuggets, burger, chopped ham and frankfurter), as follows: chicken nuggets (Nuggets Control (NC) - formulation similar to the commercial product, Nuggets Fiber Less Meat (NFLM) - 10% of meat reduction and 2% of pea fiber addition, and Nuggets Fiber Less Fat (NFLF) - 10% of fat reduction, and 2% of pea fiber addition), burger (Burger Control (HC) - similar to the commercial formulation; Burger Fiber Less Meat (BFLM) - 5% of meat reduction, and 1% of pea fiber addition, and Burger Fiber Less Fat (BFLF) - 7% of fat reduction, and 1% of pea fiber addition); chopped ham (Chopped Ham Control (CHC) - similar to the commercial formulation, and Chopped Ham Fiber Less Meat (CHFLM) - 5% of meat reduction, and 1% of pea fiber addition), chopped ham (Chopped Ham Control (CHC) - similar to the commercial formulation, and Chopped Ham Fiber Less Meat (CHFLM) - 5% of meat reduction, and 1% of pea fiber addition), and frankfurter: ( Frankfurter Control (FC) - similar to the commercial formulation; frankfurter Fiber Less Meat (FFLM): 5% of beef reduction, and 2% pea fiber addition, and Frankfurter Fiber Less Fat (FFLF) - 7% of fat reduction, and 1% of pea fiber addition). After processing the products were characterized concerning proximal composition, color determination, texture, weight loss after frying (chicken nuggets), weight loss after cooking (burger), diameter reduction (burger), drip loss (chopped ham), product outcome (frankfurter), emulsion stability (frankfurter) and sensory analysis (nine point hedonic scale acceptance test). For the nuggets NFLM and NFLF formulations presented higher levels of pH (p&lt;0.05) compared to control, and NFLF formulation presented higher (p&lt;0.05) firmness. Regarding the losses after frying, the elasticity parameters, and cohesiveness and sensory analysis were not different (p&gt;0.05) among formulations. The pea fiber addition and meat and fat reduction in burgers did not affect (p&gt;0.05) the pH levels, color parameters L* and b*; the analyzed parameters concerning texture, weight loss after cooking, diameter reduction (shrinking), and sensory analysis, only BFLM formulation presented reduction (p&lt;0.05) in the parameter a*. Regarding the chopped ham, firmness and chewiness parameters were higher (p&lt;0.05) compared to CHC formulation, CHFLM formulation presented higher L* levels (p&lt;0.05), lower parameters of color a* and b* (p&lt;0.05) compared to CHC and higher general acceptance, yet the pH levels, drip loss and the averages of the other sensory characteristics analyzed did not present difference (p&gt;0.05) among formulations. Regarding the results obtained with the frankfurter, the FFLF formulation presented lower pH levels (p&lt;0.05) compared to FC and higher values for firmness and chewiness parameters, FFLM and FFLF formulations presented lower outcome (p&lt;0.05) compared to FC and were not different to the emulsion stability, however regarding the sensory analysis FFLM formulation presented higher values (p&lt;0.05) compared to FC and FFLF concerning texture, flavor and general acceptance. According to the results it is concluded that pea fiber is a promising ingredient to be added in meat products, since the tested conditions in the partial substitution of meat and fat for pea fiber did not cause significant change in most analyzed physicochemical parameters and did not interfere the sensory acceptance in any of the studied meat products.