Adéla Dolejšová Testing the efficacy of potential therapeutics for Alzheimer,s disease Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Pharmacy The aim of this thesis was to find out whether already implemented Ellman's method, which is used to analyse irreversible inhibitors AChE, is going to be a suitable technique for measuring reversible inhibitors. Furthermore, the efficiency of newly synthesized AChE inhibitors was established. These inhibitors will be used for treating AD or as prophylaxis against neural paralytic substances. Moreover, it was compared affect the efficacy of AChE inhibitors after intramuscular and intraperitoneal administration. The measurements were done in vivo on potkan species Wistar. In the first experiment standard AChE (tacrin, 7-MEOTA, donepezil, rivastigmin) inhibitors were applied to verify the method. In the second experiment the newly synthesizes AChE (K 298, K 344, K 474) inhibitors were medicine. The results confirmed the effectiveness of the tested method on commonly used inhibitors such as donepezil and rivastigmin. Out of the newly synthesized K 298, K 344 and K 474 inhibitors none was proven to have any significant inhibiting activity. Key words: acetylcholinesterase, acetylcholinesterase inhibitors, Alzheimer disease, cholinergic system,...

Syftet med studien var att undersöka hur barnkonventionens artikel 12, barns rätt att komma till tals tillämpas i familjebehandling genom att göra en pilotstudie. Familjebehandlare inom kommunens öppenvård fick svara på hur de gjorde barn delaktiga, på vilket sätt barn kom till tals och ifall det fanns tillfällen när barn inte skulle delta i familjebehandlingen. För att få svar på dessa frågor gjordes en semistrukturerad telefonintervju. Den valda teorin var systemteori.  Studien innefattade även familjebehandling, barnkonventionen och BBIC. Resultatet visade att familjebehandlarna använde olika arbetsmetoder för att få barn att komma till tals. Det fanns en stor flexibilitet kring metoderna att göra barn delaktiga och kring att skapa möjlighet för att få barn att prata. Det fanns tillfällen då barn inte skulle delta i familjebehandlingen till exempel när föräldrarna hade egna svårigheter och när det är fanns övervägande vuxenproblem. / The purpose of the study was to investigate if the article 12 of the Convention of the Rights of the Child to be heard is applied in family treatment by making a pilot study. Family practitioners within the municipal outpatients care had to answer how they did involve the children, the manner in which children were heard and if there were times when children should not be participate in family treatment. To get answers to these questions a semi-structured survey was made. The selected theory was systems theory.  The study also included the Convention of the Rights of the Child, family treatment and BBIC. The results showed that family practitioners used various methods to get children to be heard. There was a lot of flexibility around these practices making children involved and creating the opportunity to get children to talk. There were times when children should not participate in family therapy for example when parents had their own difficulties and when it was a predominantly adult problem.

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