A produção de matérias-primas minerais é feita através de tecnologia conhecida mundialmente. No entanto, a crescente competição econômica mundial faz com que este domínio tecnológico não seja, por si só, suficiente para assegurar a sobrevivência das empresas de mineração. É necessário, também, que os métodos de gestão utilizados pela indústria de mineração estejam alinhados com a lógica da competitividade, visando maximizar os resultados econômicos financeiros das organizações como forma de sustentação no cenário globalizado atual. Esta tese está relacionada com a maximização dos resultados passíveis de serem alcançados nas indústrias de mineração, a ser obtida através de uma forma de gestão que integre a tecnologia intrínseca da Engenharia de Minas com a tecnologia de gestão da Engenharia de Produção. Esta integração é realizada através de um Modelo de Gestão Integrada, proposto nesta tese. A construção deste modelo teve como ponto de partida a experiência realizada pelo autor desta tese na mineração de fluorita no final dos anos 90, quando foram implementados alguns conceitos de Engenharia de Produção nesta atividade mineral.A partir desta experiência, sedimentada com a agregação de conceitos teóricos, foram selecionados três outros cenários na indústria de mineração para o desenvolvimento desta tese, nos quais foram utilizadas duas metodologias de pesquisa. Na mineração de calcário e na mineração de ametista, a Pesquisa-Ação foi a metodologia de pesquisa selecionada, enquanto que na mineração de carvão utilizou-se o Estudo de Caso. Na mineração de fluorita, a implementação de melhorias no processo de produção, devido à integração dos dois ramos da Engenharia considerados, resultou na redução dos gastos totais por tonelada de produto final, em função da eliminação de perdas no sistema de produção. A empresa transformou-se em uma organização de aprendizagem. Na mineração de calcário, a disseminação de conhecimentos da Engenharia de Produção através de processos de aprendizagem, propiciou o desenvolvimento de uma visão sistêmica do processo de produção por parte dos colaboradores, bem como a implementação de uma forma de gestão com o objetivo de otimizar o uso da capacidade existente. Neste cenário foi considerado, também, o desenvolvimento de novos produtos. Na mineração de ametista, o modelo de gestão proposto propiciou a realização de melhorias não somente no fluxo de produção, mas tambémna qualidade de vida dos trabalhadores devido à melhoria nas condições de trabalho desta atividade mineral. Na mineração de carvão, este trabalho procurou evidenciar a importância de se desenvolver novos produtos buscando a plena utilização da capacidade instalada. Neste cenário foram abordadas, também, questões relacionadas com o controle do meio ambiente. A análise e o estudo dos quatro cenários resultaram na construção de uma estrutura de mudanças e de um processo de mudanças para o Modelo de Gestão Integrada. A estrutura de mudanças do modelo é suportada pela integração das técnicas de lavra e beneficiamento mineral com as técnicas de gestão bem como pela inovação, que pode ser de produtos, serviços, métodos e mercado e, ainda, na forma de como é feita a gestão na Organização. Ela propicia a obtenção de melhores resultados nas organizações através da maior utilização dos ativos, com a ampliação do mercado, a redução dos custos operacionais e o aumento do lucro.O processo de mudanças do modelo tem início a partir da realização de um diagnóstico situacional para avaliar a sinergia existente na empresa entre os dois ramos da Engenharia considerados e tende a transformar a mesma em uma organização de aprendizagem para assimilação, integração e sedimentação dos conceitos, técnicas e ferramentas de Engenharia de Minas e de Engenharia de Produção. / Mineral raw material production is done through a well known worldwide technology. However, the technological domain seems to be insufficient to cope with the survival of mining industries in view of the increasing world economic competition. In addition, it is necessary that the management methods adopted by the mining industry be aligned with the logic of competitiveness aiming to maximize the financial and economic outcomes of the organizations as a way of supporting themselves in the current globalized scenario. This thesis deals with the maximization of outcomes to be achieved in the mining industries through a form of management that integrates Mining Engineering intrinsic technology with managing technology from Industrial Engineering. This integration is carried out through an Integrated Management Model proposed. The model was first devised by the author in the fluorspar mining in the late 90’s as some concepts from Industrial Engineering were being implemented. Drawing on the author’s experience, rooted in the aggregation of theoretical concepts, three other sites in the mining industry were chosen as a scenario for the work where two research methods were used. As for limestone and amethyst mining, the Survey-Action method was applied, while Case Study was used for coal mining. For fluorspar mining, the improvement in production based upon the integration of the Engineering areas resulted in a reduction of the total costs per ton for finished product, allowing the elimination of waste in such production system. The company became a learning organization. For limestone mining, the Industrial Engineering knowledge spread through learning steps provided a systemic view of the production process and implemented a management approach aiming to optimize the use of the existing capacity. In this setting, the development of new products was also taken into account. For amethyst mining, the management model provided improvements in the production flow and also improved the employee’s life quality due to better working conditions. In the last case study, coal mining, this work attempted to emphasize the importance of developing new products by using the company’s full capacity. In addition, issues related to environmental polution control were addressed. The analysis and study of the four scenarios led to the construction of a structure and a process of changes for the Integrated ManagementModel. The model changing structure is supported by the integration of mining and processing techniques with management through the innovation of products, services, methods and market. It provides better outcomes with the expansion of market share, operational costs reduction and higher profitability. The model changing process starts by a situational diagnostic to access the existing synergy between the two areas of Engineering previously mentioned and tends to transform the same into a learning organization to assimilate, integrate and consolidate the concepts, techniques and tools from Mining Engineering and Industrial Engineering.

The content of this thesis is a set of approaches that lead to a leaner enterprise. Besides the basic lean methods that are described in the theoretical part of this paper, the most attention is devoted to total productive maintenance (TPM). The practical part of this paper primarily focuses on a complete analysis of the maintenance system in Parker Hannifin and then on a project designed to implement the basic elements of TPM in the above mentioned enterprise. At the end of the piece, the project is evaluated and further ideas and recommendations for the future development of TPM in the enterprise are proposed.

During ontogeny there are a lot of changes in the entire human skeleton. This thesis deals with shape changes in the mandible, which are caused by genetic, hormonal, as well as mechanical factors. The most important mechanical factors influencing the shape of mandible are development of deciduous and permanent dentition and also development of masticatory muscles. 34 children mandibles of known age and 14 adult mandibles were analysed and compared for this thesis. Data were obtained by scanning coordinates of 36 landmarks using Microscribe G2X, and then were processed by software PAST and Morphologika2 using multivariate statistics (PCA, MANOVA). Geometric morphometrics is used for a detailed analysis of shape changes of the mandible. There is no difference between dental and chronological age. In conclusion, lower jaw narrows during growth, the body extends more in the region of third molars and the ramus grows mainly in the region of condylar process. Chin prominence also occurs during ontogeny. In the group of adult mandibles the variability is caused by coronoid process height and the body width. The hypothesis, that age groups are significantly different from each other, and therefore due to tooth mineralization there are marked shape changes, is confirmed.

No description available.

The growing negative impacts of non-biodegradable plastics derived from non-renewable materials have created increasing interest throughout the world for new materials that are both biodegradable and renewable, that can be combined with or replace traditional plastics. Plant-based thermoplastic starch (TPS), a promising alternative material to traditional petroleum based resin, is both biodegradable and renewable and has great potential for use in plastic manufacturing processes. Two major obstacles that prevent more widespread use of TPS include; TPS base material, which is typically manufactured in a flake or powder, is incompatible with standard plastics production equipment that require pelletized resin, the second reason is that TPS is difficult to mix with standard plastic materials such as High Density Polyethylene (HDPE). BiologiQ of Blackfoot Idaho through a unique manufacturing process has created a new type of TPS called EcoStarch™ Resin (ESR) that overcomes these two obstacles the material can be both pelletized and combined with various standard base plastics such as HDPE. This study evaluated and characterized the processability materials properties of ESR and HDPE blends in the Extrusion Blow Molding (EBM) by measuring wall thickness, tensile strength, tensile elongation, modulus of elongation and formability compared to 100% HDPE bottles. As the ESR content increased the uniformity of the wall thickness increased. The tensile strength increased from ESR content of 30% to 50% while the elongation decreased. Bottles were successfully extrusion blow molded with ESR content of 50%.

There is a requirement for English teachers in Sweden to adapt their teaching to align with the policy documents advocating to foster the students' continuous and lifelong learning. This study aims to address in what way the participating teachers work to create engaging learning environments and lessons that promote communication and cooperation. Furthermore, the study explores which methods the participating teachers use to differentiate instructions and make adaptations to teacher practices and materials to successfully reach each individual student. The data was gathered by conducting qualitative semi-structured interviews with four 7-9 English teachers. The interviews were focused on four main themes: (1) Adaptations for differentiated learning through multi-modality, (2) Adaptations for differentiated learning through the bi-lingual approach, (3) Adaptations for differentiated learning through cooperative learning and (4) Adaptations for differentiated learning through other practices. Based on the guidelines provided by The Swedish National Agency for Education, findings from previous research, and the data collected in this study, it becomes evident that teachers must adopt their teaching in various ways. The adaptation of teaching strategies and practices include ways to effectively engage all of their individual groups of students, as well as the utilization of visual aids, bi-lingual instructional practices, comprehensible input and output, and cooperative learning methods. The results show that these are important ways to differentiate instruction and enhance learning to support the students’ academic and cognitive growth. The presented teacher practices can aid teachers to use differentiated instruction in accordance with the needs of their individual groups of students, both in terms of classes and the individual students within those classes.

The Kentucky Re-entry Universal Payload System (KRUPS) is an adaptable testbed for atmosphere entry science experiments, with an initial application to thermal protection systems (TPS). Because of the uniqueness of atmospheric entry conditions that ground testing is unable to replicate, scientists principally rely on numerical models for predicting entry conditions. The KRUPS spacecraft, developed at the University of Kentucky, provides an inexpensive means of obtaining validation data to verify and improve these models. To increase the technology readiness level (TRL) of the spacecraft, two sub-orbital missions were developed. The first mission, KUDOS, launched August 13th, 2017 on a Terrier-Improved Malamute rocket to an altitude of ~150 km. The second mission, KOREVET, launched on March 25th, 2018 on the same type of rocket to an altitude of ~170 km. The chief purpose of both missions was to validate the spacecraft design, ejection mechanism, on-board power, data transmission, and data collection. After both missions, the overall TRL improved from 4 to 5 by validating most subsystems in a relevant environment. Both of these missions were invaluable preparation for the project's ultimate goal of releasing multiple experimental testbeds from the ISS.

Les récentes découvertes fossiles en Europe (Dmanissi, Ceprano 1, Gran Dolina) complexifient les théories phylétiques concernant les Hominidés précédant les Néandertaliens : les Anténéandertaliens. Afin de mieux appréhender les relations phylétiques entre les différentes espèces connues (Homo georgicus, H. cepranensis, H. antecessor, H. heidelbergensis et H. neanderthalensis), nous avons étudié morphologiquement les fragments originaux et proposé deux reconstitutions virtuelles de deux spécimens fossiles incomplets du Pléistocène moyen : Arago 21-47, Caune de l'Arago, Pyrénées-Orientales, France, et un spécimen inédit, Biache-Saint-Vaast 2, Pas-de-Calais, France. L'imagerie numérique a permis de corriger les déformations taphonomiques, d'assembler les fragments isolés et de proposer des reconstructions crâniennes après prélèvements virtuels sur d'autres spécimens du Pléistocène moyen, des pièces osseuses manquantes. Nous avons relevé les coordonnées 3D d'une série de points de repères sur ces reconstructions et sur un ensemble représentatif d'Hominidés fossiles pour procéder : aux comparaisons Procustes de Modélisations Segmentaires Inter Points (méthode des Thin Plates Splines) et aux Analyses en Composantes Principales de chaque modélisation crânienne (crâne, calotte crânienne, os frontal, voûte bipariétale et os pariétal droit isolé). Nous avons objectivé après comparaisons morphologiques et Procustes des fragments puis de leurs assemblages, une très grande similitude de conformation spatiale entre ces deux individus, les Néandertaliens et Ceprano 1 et anatomique entre Biache-Saint-Vaast 2 (moindre pour Arago 21) et les Néandertaliens. Nous proposons de : 1/ Considérer Arago 21 et Biache-Saint-Vaast 2 comme des Homo heidelbergensis ancien et récent ; 2/ Reconnaître la présence d'une conformation de type néandertalienne en Europe depuis le Pléistocène inférieur final ; 3/ Nommer Anténéandertaliens tous les individus présentant cette morphologie tridimensionnelle.

<p>Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor.</p><p>In a phase III study in advanced colorectal cancer the response rate was doubled when 5-FU was given as a bolus injection versus as a short infusion. The toxicity was similar and time to progression was longer in the injection group. However, overall survival was not significantly different. Dose-effect relationships of 5-FU were studied in another phase III study recruiting 312 patients. A decrease from 500 mg/m² to 400 mg/m² worsened the treatment results. A low incidence of severe toxicity was seen in both groups. An increase to 600 mg/m² worsened the toxicity without any improvement of the results.</p><p>A cytotoxic drug sensitivity test in different tumour types, mainly gastrointestinal cancer, poorly predicted treatment outcome in a phase II study.</p><p>The conventional Nordic Flv regimen was split in a phase I/II trial. An escalation of dose was possible and the response rate was 20%.</p><p>Thymidylate synthase (TS) and the gene expression of p53 were investigated by immunohistochemical technique in the primary tumours of 132 patients. None of the markers predicted the later palliative chemotherapy result. However, TS significantly predicted time to recurrence.</p><p>Serum markers were analysed before and during FLv treatment to early predict outcomes among 87 patients. TPS is promising, both as a predictive marker before start of treatment and after a short period of treatment. In the same setting, CEA had lower predictive value. S-VEGF and S-bFGF did not yield any prognostic information of later outcome. In all studies B-haemoglobin values, performance status and subjective response were strong markers, both for prediction of objective response and for survival.</p>

Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. In a phase III study in advanced colorectal cancer the response rate was doubled when 5-FU was given as a bolus injection versus as a short infusion. The toxicity was similar and time to progression was longer in the injection group. However, overall survival was not significantly different. Dose-effect relationships of 5-FU were studied in another phase III study recruiting 312 patients. A decrease from 500 mg/m2 to 400 mg/m2 worsened the treatment results. A low incidence of severe toxicity was seen in both groups. An increase to 600 mg/m2 worsened the toxicity without any improvement of the results. A cytotoxic drug sensitivity test in different tumour types, mainly gastrointestinal cancer, poorly predicted treatment outcome in a phase II study. The conventional Nordic Flv regimen was split in a phase I/II trial. An escalation of dose was possible and the response rate was 20%. Thymidylate synthase (TS) and the gene expression of p53 were investigated by immunohistochemical technique in the primary tumours of 132 patients. None of the markers predicted the later palliative chemotherapy result. However, TS significantly predicted time to recurrence. Serum markers were analysed before and during FLv treatment to early predict outcomes among 87 patients. TPS is promising, both as a predictive marker before start of treatment and after a short period of treatment. In the same setting, CEA had lower predictive value. S-VEGF and S-bFGF did not yield any prognostic information of later outcome. In all studies B-haemoglobin values, performance status and subjective response were strong markers, both for prediction of objective response and for survival.