Global ETD Search

1	Interferon-alpha immunotherapy of melanoma signal transduction, gene transcription, and the role of suppressor of cytokine signaling proteins in immune cells / Zimmerer, Jason Michael, January 2007 (has links) Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 148-166).
2	Examination of Stat6-regulated genes and their contribution to the development of a lympho-proliferative disorder / Examination of signal transducer and activator of transcription 6 regulated genes and their contribution to the development of a lympho-proliferative disorder Haffner, Christopher W. January 2007 (has links) Stat6 is a protein that activates the transcription of IL-4-stimulated genes. Amino acids critical for Stat6 function were examined in a mutational analysis of the Src homology (SH2) domain of the Stat6 protein. One mutation, substitution of two Alanines for Valine and Threonine in the N-terminal portion of the SH2 domain, produced a constitutively active form of the molecule that did not require IL-4 for activation. This mutant was named Stat6VT. Mice expressing Stat6VT in lymphocytes were generated, and it was found that approximately 10% of the population of Stat6VT mice, a lympho-proliferative disorder (LPD) occurred. In this study, we are examining genes that have a possible role in the development of this proliferative condition. Specifically, we examined the expression levels of Tiam1, Tacstdl, and Gfi-1 and Gfi-1B (genes known to regulate cellular proliferation and survival) in wildtype, normal Stat6VT and Stat6VT/LPD splenocytes by RT-PCR. Tiam1 results were inconclusive, and Tacstdl was not expressed at levels different from those seen in controls. Interestingly, Gfi-1 B, the homolog of Gfi-1, was expressed at increased levels in a specific subpopulation of cells from Stat6VT/LPD mice. Taken together, these data suggest that in cells expressing a constitutively active Stat6, increased expression of Gfi-1B may play a role in the mechanism of lymphoma development. / Department of Biology Transcription factors.
3	Adenovirus host-cell interactions : the role of capsid proteins in transduction, immune activation, and gene targeting / Schoggins, John Wesley. January 2007 (has links) Thesis (Ph. D.)--Cornell University, August, 2007. / Vita. Includes bibliographical references (leaves 152-175).
4	Signal transduction pathways and their regulation of transcriptional factors during C. elegans development Li, Xin, January 2008 (has links) Thesis (Ph. D.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references (p. 113-125).
5	Novel aspects of grass carp GHR gene regulation Brown, Gerald Francis. January 2009 (has links) Thesis (Ph. D.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 192-252). Also available in print.
6	The development of alternative methods to introduce the Ca2+-sensitive bioluminescent complex, aequorin, into zebrafish embryos / Cheung, Yuk Kam. January 2005 (has links) Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2005. / On t.p. "2+" is superscript. Includes bibliographical references (leaves 126-133). Also available in electronic version.
7	Efficient transduction and targeted expression of lentiviral vector transgenes in the developing retina Coleman, Jason Edward. January 2003 (has links) Thesis (Ph. D.)--University of Florida, 2003. / Title from title page of source document. Includes vita. Includes bibliographical references.
8	Evaluation of the deoxyribonucleoside kinase of Drosophila Melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors / Zheng, Xinyu, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 5 uppsatser.
9	Therapeutic potential of natural killer cells in multiple myeloma / Alici, Evren, January 2006 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.
10	The functional analysis of NPXY motif in [beta] integrin in vivo Ahn, Jeong H. Lee, Myeongwoo. January 2008 (has links) Thesis (M.S.)--Baylor University, 2008. / Includes bibliographical references (p. 43-48).

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