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Charakterizace proteinu SWIP, jednoho z členů WASH komplexu / Characterization of WASH complex member protein SWIPHumhalová, Tereza January 2017 (has links)
WASH complex regulates actin dynamics on endosomes by activating the Arp2/3 complex, which subsequently induces generation of branched actin patches. WASH complex is required for proper recycling of many important transmembrane proteins. Although the general physiological function of WASH complex is known, the role of its single subunits have not yet been adequately specified. This work focuses on one of these subunits - protein SWIP. This protein maintains vesicular localization of some WASH complex subunits in the slime mold Dictyostelium discoideum and a point mutation in its sequence causes a severe neurodegenerative disease - autosomal recessive intellectual disorder (ARID). Our results show that SWIP truncation results in its inability to incorporate into WASH complex. However, the C-terminal part of SWIP is able to localize onto intracellular vesicles, which are not WASH complex positive. We have also studied the impact of ARID-causing SWIP mutation, and we show, that it does neither change the protein's ability to bind the complex nor the overall localization of WASH complex.
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Chromate reduction and immobilization under high pH and high ionic strength conditions.He, Yongtian, January 2003 (has links)
Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xix, 219 p.: ill. (some col.). Includes abstract and vita. Advisor: Samuel J. Traina, Environmental Science Graduate Program. Includes bibliographical references (p. 201-219).
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Patterns, mechanics and geomorphic effects of wood debris accumulations in a forest river system /Abbe, Timothy. January 2000 (has links)
Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 201-219).
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Geomorphology and glacial geology of the Methow Drainage Basin, eastern North Cascade Range, Washington,Waitt, Richard B. January 1972 (has links)
Thesis (Ph. D.)--University of Washington. / Bibliography: l. [144]-154.
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A history of the Clark County Holiness Association, Vancouver, WashingtonWeinert, Leonard Eugene. January 1952 (has links)
Thesis (B.D.)--Western Evangelical Seminary, 1952. / Includes bibliographical references (leaves [75]-77).
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Boeing's impact on Seattle /Anderson, William, January 2009 (has links)
Thesis (M.A.)--Boise State University, 2009. / Includes abstract. Includes bibliographical references (leaves 95-98).
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Boeing's impact on SeattleAnderson, William, January 2009 (has links)
Thesis (M.A.)--Boise State University, 2009. / Title from t.p. of PDF file (viewed Sept. 23, 2009). Includes abstract. Includes bibliographical references (leaves 95-98).
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Geomorphological analysis of North Fork Toutle River, Washington, 1980-1984 /Pearson, Monte L. January 1985 (has links)
Thesis (Ph. D.)--Oregon State University, 1986. / Typescript (photocopy). Includes bibliographical references (leaves 159-167). Also available online.
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Constraints on Eruption Dynamics, Mount St. Helens, WA, 2004-2008Schneider, Andrew Daniel, 1982- 09 1900 (has links)
xi, 114 p. : ill. A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number. / Different models have been proposed for the "drumbeat" earthquakes that
accompanied recent eruptive behavior at Mount St. Helens. Debate continues as to
whether seismicity is related to brittle failure during the extrusion of solid dacite spines or
is the result of hydrothermal fluids interacting with a crack buried in the volcanic edifice.
My model predictions of steady-state conduit flow confirm the strong control that
degassing exerts on eruptive behavior. I discuss the necessary role of degassing for
extruded material to attain the high density (low vesicularity) of the observed spine
material and discuss the implications for generating seismicity. A brittle-failure source of
seismicity requires that the gouge elastic properties accommodate some strain, since the
magma compressibility in the upper conduit is too low to do so on its own. I also report on a novel method for generating high-resolution digital elevation models of fault surface
textures. / Committee in Charge: Dr. Alan Rempel, Chair;
Dr. Katharine Cashman;
Dr. David Schmidt
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The High Ross Dam/Skagit River controversy : the use of public hearings in the management of an international riverWolfe, Larry Dennis Sturm January 1974 (has links)
The High Ross controversy was a problem in the management of an International river. An international river presents a special problem because the actions of a nation upstream may cause problems
for a nation downstream or vice versa. A river is also a finite resource where uses for one purpose may exclude uses for other purposes. The use of a river for hydroelectric power, for example, may destroy fisheries. In the case of an international river, conflicting demands on water use may present serious problems
if the nations riparian to the river fail to coordinate their
planning with respect to the river.
In this study, it is normatively assumed that the best system
for insuring that the interests of all concerned will be heard is
a democracy. In a democracy it is a principle that the decision
system should respond to the preferences of its citizens. To do
this it must first be able to perceive these preferences. A public
hearing is one vehicle for accepting information concerning the
preferences of citizens. The goal of this study is to assess certain public hearings which were held in reference to the raising
of Ross Dam on the Skagit River in Washington State. The issue of
whether to raise the dam has created an international controversy
lasting for years and involving the energies of hundreds of persons
on both sides of the border. The hearings of interest in this study
are certain hearings of 1970 through 1972 held by the International
Joint Commission, the Washington Ecological Commission, and the Seattle City Council.
The approach taken in this thesis began with isolating two normative criteria among many which any democratic system must have: openness and efficiency. Openness is the ability of a system
to perceive the preferences of its citizens. This means that there should be no arbitrary restrictions upon what the decision-makers
should see. Efficiency means that the process should be simple and not limited to a select group with the most time, money, and expertise to participate.
Having established these criteria, the next step was to isolate the location in the hearings system where one might expect to find evidence of openness and efficiency. To do this, a theoretical paradigm of a communication system was constructed from political communications theory. This paradigm contained the basic components of a simple communication system. Thus, it was found that any communication
system will have messages (input), sources for those messages
(input sources), and receptors for perceiving those messages (intake elements). In rational systems there will also be a memory process which selects relevant input from among the mass of intake (screening element). These elements were analyzed in order to assess the hearings investigated.
To assemble the data necessary for assessment, a multi-method approach was used. Over four hundred articles in newspapers and periodicals were surveyed. The transcripts of the hearings and resulting
reports were closely analyzed. Finally, selected participants
who- had key roles in the hearings were interviewed. The information from these sources was used in tandem to examine particular
aspects of the hearings process which were suggested by the communication model as relevant.
The conclusions derived from this study were that with certain exceptions the procedures used in the hearings studied facilitated openness. Also, while the cost of using the hearings was very high, the participants with few exceptions felt that the expense was justified
because the issue was crucial to their interests. However, the weaknesses that did exist in openness and efficiency merit attention and should be remedied to strengthen the system. The result of this strengthening would be a more responsive and democratic process for managing international rivers. / Applied Science, Faculty of / Community and Regional Planning (SCARP), School of / Graduate
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