The location of mental nerve has been extensively studied anatomically and radiographically. This systematic review aims to summarize the common location of mental foramen (MF) as well as its anatomical variation, the accessory mental foramen (AMF). The PubMed and Google Scholar databases were both searched for the available study until Jan 2020. The database search yield 2766 study of which 47 were included in this study according to the inclusion criteria. The study concludes that in general the position of the mental foramen is between area distal to the first premolar root apex and the long axis of the apex of second premolar in 82% to 90% according to panoramic and CBCT studies reported until 2020 respectively. Importantly, AMF incident has been found in 8.3% of the population, according the all of the CBCT studies included in this systematic review.