NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Vliv Sirtuinu1 na citlivost signální dráhy přes receptor Notch k aminokyselinám v potravě u Drosophily melanogaster

ŘÍHOVÁ, Lenka January 2018 (has links)
This thesis investigates the connection between the Sirtuin1 protein (Sirt1) and the Notch signaling pathway in Drosophila melanogaster. We used RNAi to downregulate the Sirt1 gene expression in a tissue specific manner in the muscles, brain, fat body, and wing disc and tested the sensitivity of Notch pathway to dietary amino acids. We identified tissue specific requirements for Sirt1 protein to mediate the sensitivity of Notch pathway to amino acids.

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