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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Studium modelových lipidových membrán obsahujících omega-hydroxylované ceramidy / The study of model lipid membranes containing omega-hydroxylated ceramides

Svatošová, Linda January 2021 (has links)
Charles University, Faculty of pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Linda Svatošová Supervisor: PharmDr. Lukáš Opálka, Ph.D. Title of diploma thesis: The study of model lipid membranes containing omega- hydroxylated ceramides Acylceramides (EO-Cer) belong to a class of ceramides (Cer) with an ultralong acyl chain whose ω-hydroxyl group is esterified with linoleic acid. The importance of EO-Cer lies in the formation of the long periodicity phase (LPP) and the corneocyte lipid envelope (CLE), which are indispensable components for the skin functioning as a barrier. Disorders in EO-Cer biosynthesis are associated with insufficient production of CLE and LPP leading to many skin diseases, including some types of ichthyosis. One of the enzymes that is deficient in such ichthyoses is PNPLA1. Insufficient function of this enzyme disables ω-esterification with linoleic acid, and thus the formation of EO-Cer. On the contrary, their precursors, i.e. ω-hydroxylated ceramides (O-Cer), are cumulated. The aim of this thesis was to prepare model membranes containing O-Cer and to study the effects of O-Cer on the lipid organization and barrier properties of model membranes. Within this thesis, two types of membranes were prepared - the first type were membranes...

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