With steadily increasing computational power, computational fluid dynamics (CFD) can be applied to unsteady problems such as seakeeping simulations. Therefore, a good balance between accuracy and computational speed is required. This thesis investigates the application of CFD to seakeeping performance predictions and aims to propose a best-practice procedure for efficient seakeeping simulations. The widely used KVLCC2 research vessel serves as a test case for this thesis and FINEŠ/Marine software package is used for CFD computations. In order to validate the simulations, results are compared to recent experimental data from SSPA as well as predictions with potential ˛ow code SHIPFLOW® Motions. As for the calm water simulations, both inviscid and viscous ˛ow computations are performed in combination with three mesh refinement levels. Seakeeping simulations with regular head waves of different wavelengths are set-up correspondingly. Furthermore, different strategies for time discretization are investigated. With the given computational resources, it is not feasible to complete seakeeping simulations with a ˝ne mesh. However, already the coarse meshes give good agreement to experiments and SHIPFLOW® Motions' predictions. Viscous ˛ow simulations turn out to be more robust than Euler ˛ow computations and thus should be preferred. Regarding the time discretization, a fixed time discretization of 150 steps per wave period has shown the best balance between accuracy and speed. Based on these findings, a best-practice procedure for seakeeping performance predictions in FINEŠ/Marine is established. Taking the most efficient settings obtained from head wave simulations, the vessel is subjected to oblique waves with 160° encounter angle. Under similar wave conditions, CFD predictions of a similar thesis show close agreement in terms of added wave resistance. Compared to the previous head wave conditions of this study, added resistance in 160° oblique waves is found to be significantly higher. This underlines that oblique bow quartering waves represent a relevant case for determining the maximum required power of a ship. CFD and potential ˛ow show similar accuracy with respect to ship motions and added wave resistance, albeit potential ˛ow outperforms CFD in terms of computational speed. Hence, CFD should be applied in cases where viscous effects are known to have large influence on a vessel's seakeeping behavior. This can be the case if motion control and damping devices are to be evaluated, for instance. / Tack vare den stadigt ökande beräkningskraften kan beräkningsuiddynamik (CFD) idag användas på beräkningsintensiva problem som sjöegenskapssimulationer. Den här rapporten undersöker användning av CFD på sjöegenskapsprestanda och syftar till att foreslå ett best-practice förfaringssätt för effektiv sjöegenskapssimulationer. Forskningsskrovet KVLCC2 fungerar som ett testfall för denna rapport och FINE—/Marine-mjukvarupaketet används för CFD-beräkningar. Viktiga parametrar, såsom ödestyp, beräkningsnät och tidssteg varierars systematiskt. Resultaten jämförs med experiment gjorda vid SSPA. Baserat på resultaten förelås en best-practice. Den föreslagna best-practice användas vidare för berökningar av sjöegenskaper i sneda vågor. Jämförelse av resultaten med liknande studier visar god överensstämmelse. Genom att använda det föreslagna förfarandet för best-practice kan CFD-sjöegenskapssimulationer användas på fall där viskösa krafter måste beaktas, till exempel rörelseregleringsanordningar.