The evolution of technology has led to a need for business leaders to embrace disruptive technology for the purpose of capturing new markets and remaining competitive. Multiple challenges have been faced by business leaders in the processes of integrating and sustaining disruptive innovations, resulting in the failure to achieve expected efficiency and profitability. The purpose of this multiple case study was to explore strategies used by business leaders to integrate and sustain disruptive innovations. The conceptual frameworks were Roger's diffusion of innovation theory and Christensen's disruptive innovation theory. Semistructured interviews were administered to 10 business leaders and employees from institutions of higher learning in the Northeastern region of the United States. The participants were selected using a purposive nonrandom sampling technique. The selection criteria included organizational leaders, technology professionals, training and development professionals, and organizational end-users. Three themes and several subthemes were identified. The strategies for integrating and sustaining disruptive innovations include training, changeover mechanisms, and the use of critical resources. The procedural and structural factors in processes to integrate and sustain disruptive innovations include identifying critical success factors, ascertaining benchmarks, determining levels of support and effectiveness. Obstacles faced during the processes of integrating and sustaining disruptive innovations were categorized into human, technology, changeover, and external issues. Social change may be realized through the improved success rates of small business leaders implementing disruptive innovations by increasing meaningful employment and enhancing livelihoods.