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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Optimisation of autoencoders for prediction of SNPs determining phenotypes in wheat

Nair, Karthik January 2021 (has links)
The increase in demand for food has resulted in increased demand for tools that help streamline plant breeding process in order to create new varieties of crops. Identifying the underlying genetic mechanism of favourable characteristics is essential in order to make the best breeding decisions. In this project we have developed a modified autoencoder model which allows for lateral phenotype injection into the latent layer, in order to identify causal SNPs for phenotypes of interest in wheat. SNP and phenotype data for 500 samples of Lantmännen SW Seed provided by Lantmännen was used to train the network. Artificial phenotype created using a single SNP was used during training instead of real phenotype, since the relationship between the phenotype and SNP is already known. The modified training model with lateral phenotype injection showed significant increase in genotype concordance of the artificial phenotype when compared to the control model without phenotype injection. Causal SNP was successfully identified by using concordance terrain graph, where the difference in concordance of individual SNPs  between the modified modified model and control model was plotted against the genomic position of each SNP. The model requires further testing to elucidate its behaviour for phenotypes linked to multiple SNPs.

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