<p>U ovom radu je ispitivan uticaj Antitoksičnognutritiva(ATN), preparata na bazi prirodnih aluminosilikata,na biohemijske, fiziolo&scaron;ke, tehnolo&scaron;ke i proizvodne parametre uzgoja pilića. ATN je sme&scaron;a zeolita klinoptilolita, gline monmorilonita i male količine aktivnog uglja. Dodatak ovog preparata u hranivo za piliće u količini od 5 g/kg nije izazvao promene u normalnoj biohemijskoj i fiziolo&scaron;koj homeostazi životinja. Hematolo&scaron;ki parametri, koncentracija metabolita, elektrolita i aktivnost enzima seruma i jetre je bila u granicama referentnih vrednosti. ATN ne utiče na prirast životinja, ni na konverziju hrane, ali dovodi do povećanja relativnih masa pojedinih organa digestivnog trakta.</p><p>Uočava se da dodatkom ATN-a u hranivo dolazi do smanjenja količine masti a povećanja količine proteina u belom mesu. ATN takođe povećava i sadržaj pepela u<br />belom i crvenom mesu.</p><p>Akutni ili hronični tronedeljni oralni unos pojedinih toksikanata (mikotoksina aflatoksina B1i ohratoksina A, herbicida parakvata, jona olova ili toksina<br />cijanobakterija-mikrocistisa) dovodi do poremećaja normalne biohemijske i fiziolo&scaron;ke homeostaze pojedinih organa i tkiva pilića, &scaron;to je utvrđeno na osnovu rezultata hematolo&scaron;kih i biohemijskih analiza, određivanja enzima antioksidativne za&scaron;tite i lipidne&nbsp;<br />peroksidacije, kao i odredjivanja parametara uzgoja i težine organa. ATN, dodat u hranu u količini od 5 g/kg, mogao da bude dobar protektivni agens za delovanje aflatoksina, parakvata, jona te&scaron;kih metala i mikrocistisa, ali ne i ohratoksina.</p> / <p>This study investigated the effects of dietary supplementation with hydrated aluminosilicate (Antitoxic Nutrient-ATN), based on zeolitic ore (clinoptilolite), clay bentonite (montmorillonite),and small amounts of activated charcoal, on&nbsp; performance, hematological, serum, and liver biochemical parameters, as well as organ weights and meat quality in broiler chickens. The dietary addition of ATN has&nbsp; no adverse effects on serum and liver biochemical parameters and does not affect the normal physiological homeostasis of animals. However, the results of this study demonstrate that supplementation with 5 g/kg of ATN influenced organ weights, and chemical composition of broiler chicken meat.</p><p>This study also evaluated the effectiveness of ATN to protect broilers from adverse effects of five different toxic substances (mycotoxins aflatoxin B1, and ochratoxin A, herbicide paraquat, heavy metal ions supplied as lead-acetate, and microcystis, toxin of cyanobacteria). Toxic substances induced oxidative stress and disturb normal biochemical and physiological homeostasis of different tissues and organs in poultry. The results from this study demonstrate that the biochemical variables of serum, liver, kidney, lung and other organs were negatively affected by all five toxic substances. The additionof 5 g/kg of ATN was protective against aflatoxin B1, lead-acetate, paraquat and microcystis, but not against ochratoxin A.</p>