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Studies on upregulation of amyloid precursor protein in response to traumatic brain injury /Heuvel, Corinna van den. January 1999 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Pathology, 1999. / Appendum pasted into front end-papers. Bibliography: leaves xiii-xliii.
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Studies on upregulation of amyloid precursor protein in response to traumatic brain injury / Corinna van den Heuvel.Heuvel, Corinna van den January 1999 (has links)
Appendum pasted into front end-papers. / Bibliography: leaves xiii-xliii. / xi, 195, xliii leaves : ill. (chiefly col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Traumatic brain injury (TBI) effects neuronal cell bodies (NCBs), axons and dendrites in a complex fashion, producing a spectrum of damage dependent on the initial injury and secondary effects. Accumulation of amyloid precursor (APP) in NSBs and axons is a feature of TBI. This accumulation may be due to impairment of the axonal transport of APP and/or upregulation of APP mRNA synthesis. This thesis hypothesizes that mechanical deformation, which is not severe enough to cause immediate cell death, results in increased APP mRNA and antigen expression as an acute phase response to injury. / Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 1999
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Molecular mechanisms of synapse dysfunction : modeling neurological disease by viral-mediated protein overexpression in mammalian CNS neurons /Ting, Jonathan T. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 100-123).
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The effect of neurosin on amyloid precursor protein processing.January 2005 (has links)
Leung Man-hin. / Thesis submitted in: August 2004. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (leaves 119-133). / Abstracts in English and Chinese. / Abstract --- p.ii / Acknowledgement --- p.iv / Abbreviations --- p.v / Figure List --- p.vii / Chapter Chapter 1: --- General introduction / Chapter 1.1 --- Introduction --- p.1 / Chapter 1.2 --- Pathogenesis of Alzheimer's disease / Chapter 1.2.1 --- Amyloid cascade hypothesis --- p.2 / Chapter 1.2.2 --- Tauopathy --- p.5 / Chapter 1.3 --- The amyloid precursor proteins / Chapter 1.3.1 --- Structure of amyloid precursor proteins and related peptides --- p.5 / Chapter 1.3.2 --- Amyloid precursor protein mutations --- p.6 / Chapter 1.3.3 --- Amyloid precursor protein processing --- p.10 / Chapter 1.3.4 --- Physiological roles of APP --- p.12 / Chapter 1.3.5 --- The pathophysiological role of Ap --- p.17 / Chapter 1.3.6 --- The pathophysiological role of APP-CTF --- p.20 / Chapter 1.4 --- The role of proteases in amyloid precursor protein processing / Chapter 1.4.1 --- α-secretase and p-secretase --- p.22 / Chapter 1.4.2 --- γ-secretase complex --- p.30 / Chapter 1.4.3 --- Caspases --- p.36 / Chapter 1.4.4 --- Kallikrein-like proteases --- p.37 / Chapter 1.5 --- Objective of the present study --- p.40 / Chapter Chapter 2: --- Materials and methods / Chapter 2.1 --- Experimental procedure / Chapter 2.1.1 --- Plasmid construction --- p.42 / Chapter 2.1.2 --- "DNA purification, ligation and restriction enzyme digestion" --- p.44 / Chapter 2.1.3 --- Competent cell preparation --- p.47 / Chapter 2.1.4 --- Transformation --- p.47 / Chapter 2.1.5 --- Plasmid miniprep --- p.48 / Chapter 2.1.6 --- Prokaryotic expression of neurosin --- p.49 / Chapter 2.1.7 --- SDS-PAGE --- p.51 / Chapter 2.1.8 --- Protein sample preparation --- p.51 / Chapter 2.1.9 --- Western Blot --- p.52 / Chapter 2.1.10 --- Immobilized metal affinity chromatography --- p.54 / Chapter 2.1.11 --- Enzyme assay --- p.55 / Chapter 2.1.12 --- Cell culture and transfection --- p.56 / Chapter 2.1.13 --- Live cell imaging --- p.57 / Chapter 2.2 --- Materials --- p.59 / Chapter Chapter 3 : --- Results / Chapter 3.1 --- Recombinant expression and characterization of neurosin / Chapter 3.1.1 --- Construction of neurosin prokaryotic expression vectors --- p.62 / Chapter 3.1.2 --- Prokaryotic expression of neurosin --- p.64 / Chapter 3.1.3 --- Neurosin was expressed as inclusion bodies --- p.68 / Chapter 3.1.4 --- Co-expression of molecular chaperones with neurosin --- p.70 / Chapter 3.1.5 --- Purification of recombinant neurosin by IMAC --- p.76 / Chapter 3.1.6 --- Enzyme assay --- p.81 / Chapter 3.2 --- Effect of neurosin on APP processing in neuronal cells / Chapter 3.2.1 --- Generation of APP constructs --- p.84 / Chapter 3.2.2 --- Expression of APP in mammalian cultures --- p.89 / Chapter 3.2.3 --- Cellular localization of APP and its processing products --- p.96 / Chapter 3.2.4 --- The role of over-expression of neurosin on APP processing in B103 cells --- p.101 / Chapter Chapter 4: --- Discussion / Chapter 4.1 --- Discussion of neurosin expression --- p.103 / Chapter 4.2 --- Discussion of APP cell model --- p.109 / Chapter 4.3 --- Conclusion --- p.119 / References --- p.121 / Appendix / Chapter A. --- Tables on primers used --- p.138 / Chapter B. --- Plasmid maps --- p.139 / Chapter C. --- Raw data on the DNA sequencing --- p.141
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Alzheimer's disease-related amyloid precursor protein and presenilin genes : normal function and pathophysiology /Flood, Fiona, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
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Regulation of the amyloid precursor protein (APP) gene promoter by hypoxia /Bielecki, Agnieszka. January 1900 (has links)
Thesis (M.Sc.) - Carleton University, 2006. / Includes bibliographical references (p. 106-118). Also available in electronic format on the Internet.
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Studying physiological functions of APP using mice modelsLi, Hongmei January 2008 (has links)
Dissertation (Ph.D.) -- University of Texas Southwestern Medical Center at Dallas, 2008. / Vita. Bibliography: p. 97-121.
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Alzheimer's disease (AD) like pathology following developmental lead exposure in primates and the role of aging in AD-related genes regulation in rodents and primates /Wu, Jinfang, January 2008 (has links)
Thesis (Ph.D.) -- University of Rhode Island, 2008. / Typescript. Includes bibliographical references (leaves 141-159).
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The inheritance of loss Caspase 6 activity and effect in human naurons caused by familial Alzheimer's Disease associated mutants /Sivananthan, Saskia Nikali, January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Neurology and Neurosurgery. Title from title page of PDF (viewed 2009/08/07). Includes bibliographical references.
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The Alzheimer's disease beta amyloid protein precursor: Analysis of the carboxyl terminus of its soluble derivativesPasternack, Jennifer Martine January 1992 (has links)
No description available.
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