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Thesis (MSc)--Stellenbosch University, 2014. / ENGLISH ABSTRACT: Clinical results have indicated that abuse of multiple drugs/substances has devastating health and social consequences. The combined abuse of alcohol and the highly addictive methamphetamine has worsened the drug epidemic in South Africa, especially in the Western Cape Province. Using non-linear ordinary differential equations, we formulate a deterministic mathematical model for alcohol-methamphetamine coabuse epidemic. We prove that the growth of the co-abuse epidemic is dependent on the threshold parameters of the individual substances of abuse. The substance with the maximum reproduction number dominates the epidemic. We also prove that the equilibria points of the co-abuse sub-models are locally and globally asymptotically stable when the sub-model threshold parameters are less than unity. Using parameters values derived from the sub-model fittings to data, a population estimate of co-users of alcohol and methamphetamine under treatment is estimated with a prevalence of about 1%. Although the results show of a small proportion of co-users of alcohol and methamphetamine in the province, the prevalence curve is indicative of a persistent problem. Numerical simulation results reveal that co-abuse epidemic would persists when both reproduction numbers are greater than one. Results from sensitivity analysis shows that the individual substance transmission rates between users of methamphetamine and/or alcohol and the general susceptible population are the most vital parameters in the co-abuse epidemic. This suggests the need to emphasise on preventive measures through educational campaigns and social programs that ensure minimal recruitment into alcohol or methamphetamine abuse. Model analysis using the time-dependent controls (policies) emphasizes the need to allocate even more resources on educational campaigns against substance abuse and on effective treatment services that minimizes or eliminates rampant cases of relapse into substance abuse. / AFRIKAANSE OPSOMMING: Kliniese resultate toon dat die misbruik van meer as een dwelmmiddel verwoestende gesondheids-en sosiale gevolge het. Die gekombineerde misbruik van alkohol en die hoogsverslawende methamphetamine het die dwelm-epidemie in Suid-Afrika vererger, veral in die Wes-Kaapse provinsie. Deur van nie-lineere gewone diffensiaalvergelykings gebruik te maak, formuleer ons ’n deterministiese wiskundige model vir epidemie van die gesamentlike misbruik van alkohol en methamphetamine. Ons toon aan dat die groei van die sogenaamde mede-misbruik epidemie afhanklik is van die drumpelparameters van die individuele middels wat misbruik word. Die middels met die grootste voortbringende syfer domineer die epidemie. Ons bewys ook dat die ekwilibriumpunte van die mede-misbruik submodelle plaaslik en globaal asimptoties stabiel is wanneer die sub-model drumpelparameters kleiner as een is. Deur die submodelle op werklike data te pas word waardes vir die drumpelparameters afgelei en word daar beraam dat daar ongeveer 1% van die populasie mede-misbruikers van alkohol en methamphetamine onder behandeling is. Alhoewel die data ’n klein persentasie van mede-misbruikers van alkohol en methamphetamine in die provinsie toon, dui die voorkomskurwe op ’n groeiende endemie en voortdurende probleem. Resultate uit numeriese simulasie toon dat die mede-misbruik epidemie sal voortduur indien beide reproduserende syfers groter as een sal wees. Resultate van sensitiwiteitsanalise toon dat die individuele middeloordragkoerse tussen gebruikers van methamphetamine en/of alkohol en die gewone vatbare populasie die mees noodsaaklike parameters in die mede-misbruik epidemie is. Dit stel voor dat daar meer klem gelê moet word op voorkomingsmaatreëls deur opvoedkundige veldtogte en sosiale programme om te verseker dat minder alkohol en/of methamphetamine misbruik sal word. Model-analise wat gebruik maak van tyd-afhanklike kontroles (beleide) lê verder klem op die feit dat selfs meer hulpbronne aan opvoedkundige veldtogte teen dwelmmisbruik toegewy moet word, asook die effektiewe behandeling wat gevalle van terugval in dwelmmisbruik sal minimeer of elimineer.

Background: Alcohol addiction is a widespread social problem worldwide. Countries with high prevalence of alcohol consumption try to react on this situation. Addiction treatment is closely determined by public health and the health care system of each country, which define its role. Aims: The main aim of this study is a description of comparison focused on alcohol abuse treatment in the Czech Republic, Belgium and Uganda. Secondary aim is to understand basic principles of treatment in chosen countries through qualitative research methods and the insight into advantages and disadvantages of treatment programs. Methods: The concept of the study is based on a qualitative research methodology. The starting point of this research was an analysis of interviews conducted by David Kalema with patients treated in medical facilities in Belgium and Uganda. Also semi-structured interviews were conducted with patients of two mental hospitals in the Czech Republic. The selection method used in this study was a purposeful sampling method. Research was carried out with 12 respondents from the Czech Republic, 10 from Belgium and 10 from Uganda. The final data was analyzed according to the procedures of grounded theory. Results: One of the major factors identified was the function of case management approach in...

This study utilized the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) and the Personality Inventory for Children, Second Edition (PIC-2) as measures of cognitive and personality functioning for children with Fetal Alcohol Spectrum Disorder with comorbid Attention-Deficit/Hyperactivity Disorder (FASD/ADHD) and children with ADHD. This study revealed the WISC-IV and PIC-2 each provided unique information to the neuropsychological examination of children with FASD/ADHD and ADHD. Furthermore, the FASD/ADHD group and the ADHD group were found to have significant differences in terms of cognitive and personality functioning. The results also indicated the groups could be differentiated using the WISC-IV and the PIC-2 independently with a high degree of accuracy. The current study further elucidated the unique cognitive and personality profiles of children with FASD/ADHD and ADHD and identified key areas of difference between the two groups. Moreover, the current study documented the utility of the Classification and Regression Tree procedure as a useful diagnostic tool in the differential diagnosis of FASD versus ADHD using commonly used cognitive and personality measures. / Department of Educational Psychology

The majority of children with Fetal Alcohol Spectrum Disorder (FASD) have comorbid Attention-Deficit Hyperactivity Disorder (95%; Fryer et al., 2007). The goal of this study was to compare the neuropsychological and adaptive skills profiles of children with Attention-Deficit/Hyperactivity Disorder (ADHD) with or without comorbid FASD in order to improve interventions for both of these populations. This study paid particular attention to neurological, cognitive, and adaptive skills strengths and weaknesses in children with ADHD/FASD and children with ADHD without comorbid FASD. By identifying these strengths and weaknesses recommendations were able to be made to help the functioning of each of children with ADHD/FASD and children with ADHD in their home, community, and school environments based on their neuropsychological and adaptive skills profiles. Neurologically, children with ADHD/FASD and children with ADHD have been shown to have impairment in the basal ganglia, cerebellum, corpus callosum, frontal lobes, hippocampus, hypothalamus, occipital lobes, parietal lobes, temporal lobes, and thalamus. Cognitively, children with ADHD have been shown to have difficulty in areas such as working memory and processing speed with less significant deficiencies in verbal ability and perceptual organization whereas children with ADHD/FASD have shown impairment in all of these cognitive abilities. When compared to typically developing children with approximately the same level of general intelligence, children with ADHD have been shown to obtain lower standard scores in all domains of adaptive functioning and children with FASD have been shown to demonstrate significant adaptive skills deficits throughout the lifespan. This study used specialized statistical procedures including Multivariate Analysis of Variance (MANOVA), Discriminant Analysis (DA), and Classification and Regression Tree (CART) in order to investigate the neuropsychological and adaptive skills in 81 children with ADHD/FASD and 147 children with ADHD. The statistical analyses indicated that children with ADHD/FASD and children with ADHD have similar cognitive and adaptive skills profiles; however, the children with comorbid ADHD/FASD were significantly more impaired in verbal ability, perceptual reasoning, working memory, processing speed, and overall adaptive skills. The current study took a step forward in helping to make diagnostic decisions based on the similarities and differences between children with ADHD with and without comorbid FASD. Given the data from the current study indicating the significant differences in cognitive and adaptive skills in these two samples, it is imperative that psychopharmacological interventions be tailored to these two seemingly similar yet different groups, especially as these two groups may respond differently to stimulant medication, the first line of medicinal treatment for ADHD. Children with ADHD/FASD should also be treated with more intense interventions in the home, community, and school than children with ADHD. / Department of Educational Psychology

The aim of this study was to evaluate the relationship between alcohol advertising and alcohol consumption among the youth in the Vaal triangle, south of Gauteng. The study was conducted in four high schools under Sedibeng West District of the Gauteng Department of Education. A quantitative approach in the form of a questionnaire was used to conduct the research. Results obtained indicated that there is no significant correlation between alcohol advertising and alcohol consumption among the respondents. Drawing on the findings and literature review, recommendations were made to government, the liquor industry and schools that participated in the study. Limitations of the study were identified and recommendations were made for the benefit of future research. The primary and secondary objectives of the study were successfully realised in this study. / MBA, North-West University, Potchefstroom Campus, 2015

The aim of this study was to evaluate the relationship between alcohol advertising and alcohol consumption among the youth in the Vaal triangle, south of Gauteng. The study was conducted in four high schools under Sedibeng West District of the Gauteng Department of Education. A quantitative approach in the form of a questionnaire was used to conduct the research. Results obtained indicated that there is no significant correlation between alcohol advertising and alcohol consumption among the respondents. Drawing on the findings and literature review, recommendations were made to government, the liquor industry and schools that participated in the study. Limitations of the study were identified and recommendations were made for the benefit of future research. The primary and secondary objectives of the study were successfully realised in this study. / MBA, North-West University, Potchefstroom Campus, 2015