The proposition that inadequate health literacy on antenatal care (ANC) is exacerbating maternal mortality in sub Saharan Africa (SSA) is undisputable. Yet, little is known about ANC literacy in Lesotho, an SSA country with high maternal mortality rates. This cross-sectional study explored the levels of ANC literacy and the associated factors in 451 purposively sampled women in two districts using a semi-structured questionnaire making recourse to statistical principles. Overall, 16.4% of the participants had grossly inadequate ANC literacy, while 79.8% had marginal levels. Geographic location and level of education were the most significant predictors of ANC literacy. Participants had the lowest scores on knowledge of danger signs in pregnancy and true signs of labour. Furthermore, significant knowledge gaps on baby layette and mother’s essential items for delivery were found. Adequate ANC literacy is critical to reducing maternal mortality in Lesotho. Improving access to ANC education, particularly in rural areas is recommended. / Health Studies / M.A. (Nursing Science)