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Introduction: In the past decades, the representation of seniors is increasing and the knowledge and the approaches to geriatrics and gerontology are more and more important. With the increasing age, there is also a grow in number of diseases and drugs (high incidence of polymorbidity and polypharmacotherapy). With regard to physiological, pathological and other changes related to aging, there is a higher risk of complications after drugs. For the rational use of drugs with old people, it is essential to eliminate negative influence and negative impacts of various drugs or non-drugs factors and to ensure the maximum effectiveness, safety and cost-effectiveness of given drugs regimens. Especially using anticholinergic drugs can have negative effect on older people (e.g confusion) while aging, "the cholinergic deficit" is increasing. As the anticholinergic drugs is necessary for seniors, it is required to use drugs with the lowest anticholinergic activity. This diploma thesis evaluates the prevalence of anticholinergic drugs usage. It also elaborates which anticholinergic drugs and combinations of these anticholinergic drugs are most commonly prescribed to geriatric patients in acute, ambulatory and pharmacy healthcare in the Czech Republic. Methodology: The analyzed data were collected from 2018 to...