Global ETD Search

1	Comparison of Ankle Kinematics between Soft and Semi-Rigid Ankle Orthoses for Field-Sport Activities Becker, Shannon 05 December 2013 (has links) Purpose of study: Examine ASO (soft) and Malleoloc semi-rigid stirrup (SRS) ankle orthosis designs on ankle kinematics during field-sport movements: sprint, one-legged jump, and 45-degree cut. Participants: 13 competitive Ultimate players who regularly wore an ankle orthosis during physical activity. Methods: ASO or Malleoloc orthosis was randomly assigned to each person. Kinematic data were captured while the participants performed several trials for each movement in a motion analysis laboratory. Participants repeated the protocol with the other orthosis. Results: ASO allowed significantly more plantar-flexion during weight acceptance of the planting foot in cutting (p=0.038). In jumping, the Malleoloc allowed significantly more eversion-inversion range during stance (p=0.048) and eversion-inversion angular velocity from midstance to toe-off (p=0.026). Qualitative data also showed a significant preference for ASO. Conclusion: Hypotheses that ankle inversion and eversion would be greater with the ASO; and plantar-flexion and dorsiflexion would be greater with the Malleoloc were refuted. ASO Malleoloc ankle kinematics field-sport activities
2	Comparison of Ankle Kinematics between Soft and Semi-Rigid Ankle Orthoses for Field-Sport Activities Becker, Shannon January 2013 (has links) Purpose of study: Examine ASO (soft) and Malleoloc semi-rigid stirrup (SRS) ankle orthosis designs on ankle kinematics during field-sport movements: sprint, one-legged jump, and 45-degree cut. Participants: 13 competitive Ultimate players who regularly wore an ankle orthosis during physical activity. Methods: ASO or Malleoloc orthosis was randomly assigned to each person. Kinematic data were captured while the participants performed several trials for each movement in a motion analysis laboratory. Participants repeated the protocol with the other orthosis. Results: ASO allowed significantly more plantar-flexion during weight acceptance of the planting foot in cutting (p=0.038). In jumping, the Malleoloc allowed significantly more eversion-inversion range during stance (p=0.048) and eversion-inversion angular velocity from midstance to toe-off (p=0.026). Qualitative data also showed a significant preference for ASO. Conclusion: Hypotheses that ankle inversion and eversion would be greater with the ASO; and plantar-flexion and dorsiflexion would be greater with the Malleoloc were refuted. ASO Malleoloc ankle kinematics field-sport activities
3	Chemically Modified Oligonucleotides Silence Mutant SPTLC1 in an in vitro Model of HSAN1 Karnam, Havisha Bindu 05 September 2018 (has links) Hereditary sensory and autonomic neuropathy type 1 (HSAN1) is a monogenic, autosomal dominantly inherited, neurodegenerative disorder resulting in loss of pain and temperature sensation in the distal limbs. HSAN1 is caused by point mutations in a single allele of serine palmitoyltransferase long chain base 1 (SPTLC1), resulting in production of neurotoxic deoxysphingolipids (dSLs). Oligonucleotide therapeutics (ONTs) can be used to downregulate the mutant allele and/or the wild type allele and thus are viable treatment strategies. We investigated the ability of two classes of ONTs, short interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), to downregulate SPTLC1 in an in vitro model of HSAN1 derived from the C133W mouse model overexpressing mutant hamster SPTLC1. We screened a panel of siRNAs and ASOs targeting mutant hamster SPTLC1 and identified four lead compounds. We demonstrated these compounds’ ability to reduce mutant hamster SPLTC1 and/or wild type mouse SPTLC1 mRNA in CHO cells and C57BL/6J embryonic mouse primary cortical neurons. We then showed that these compounds downregulate hamster and mouse SPTLC1 mRNA and protein in embryonic primary cortical neuron cultures derived from C133W mice. These compounds demonstrate therapeutic potential and should be developed further in vivo. siRNA ASO gapmer oligonucleotide therapeutic HSAN1 SPTLC1 Neurosciences
4	Relationen mellan WHO:s globala aidsprogram och ickestatliga organisationer : Kan bristen på samarbete förklaras utifrån new interdependence approach eller medlemsstaternas agerande? / Relations Between WHO Global Programme on AIDS and NGOs : Can the lack of cooperation be explained by new interdependence approach or the actions of member states? Tengdelius, Daniel January 2023 (has links) This thesis aims to understand why the World health organization’s Global programme on aids (WHO GPA) does not appear to be able to collaborate with non-governmental actors (NGO), even though booth WHO GPA and NGO`s appears to value and seek cooperation. The purpose of this thesis is to examine whether the lack of cooperation between WHO GPA and NGO: s can be explained using new interdependence approach or if the actions of WHO´s member states v. The selected case in this thesis is WHO GPA which existed from 1987 to 1995 and represents the first anti-aids program supported by UN and its member states. WHO GPA is therefore active in a policy area where a lot of interactions with NGO: s could be expected. To analyse the apparent lack of cooperation between WHO GPA and relevant NGO: s, this article will apply the theories new interdependence approach and neorealism. To explain the research questions, how does the interaction between WHO GPA and NGO: s appear within the global effort against the aids pandemic, what role did member states have in limiting or enable formal cooperation between WHO GPA and NGO:s and finally how the theory new interdependence approach can explain the interactions between the WHO GPA and NGO: s. To answer the research questions this thesis will apply a qualitative text analysis on material from WHO GPA, for example annual reviews, as well as previous research articles and books that concerns the WHO GPA. The analysis concludes that the interaction between WHO GPA and NGO: s, can be explained with the fact that informal cooperation does appear but not formal cooperation. This appears to be because while booth WHO GPA and NGO: s seeks support and cooperation, the interactions between them is still affected by mistrust. The member state’s role in limiting or enabling cooperation can be answered two levels, globally where powerful states have strong informal powers to control WHO GPA. When NGO: s are granted formal representation, the selection of NGO: s is not representative of the larger NGO community and not in response to cooperation between WHO GPA and NGO:s. Recipient states does also appear to hinder cooperation between NGO:s, WHO GPA and national aids programmes, because of rivalry between the state and NGO over limited aid. Finally, new interdependence approach appears to explain to lack of formal cooperation, because of a lack of distinct resources. However, it cannot explain the cases where NGO: s achieved official representation as the result of cross-national layering. WHO WHO GPA Policy Co-optation cooperation conflict competition NGO International organisation World Health Organisation Donors Tana Johnson new interdependence approach interdependence approach AID Neorealism Realism Interdependent AIDS HIV Values Resources e cross-national layering Policy nternational Bureaucracy international bureaucrats Intergovermental organisations UN United Nations Transnational organisations Non-govermental organisations Representation national aids programmes Rivalty International cooperation AIDS service organization Food and agriculture organization ASO FAO National aids programme NAP National aids control programme NCAP Formal cooperation Informal cooperation official representation informal power WHO Icke-statliga organisationer AIDS HIV Internationella organisationer Världshälsoorganisationen FN Förenta Nationerna Globalisering Samarbete Internationella relationer Offentlig förvaltning Internationella byråkrater Internationell byråkrati icke-statliga organisationer globala aidsprogram WHO:s globala aidsprogram informell makt Bistånd new interdependence approach Interdependence approach Realism Neorealism internationel organisation offentlig förvaltning Statsvetenskap Regelöverlappning möjlighetsstrukturer asymmetrisk makt Givarestater Mottagarestater mottagareländer politiskt samarbete Internationella regler Nationalstat Internationella aktörer transnationella organ Policy Sekretariat Tana Johnson Cross-national layering Sammarbete Konflikt ömsesidigt beroende värld Värderingar Resurser Klassisk Realism Rivalitet Public Administration Studies Studier av offentlig förvaltning Globalisation Studies Globaliseringsstudier

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