none

Magister Scientiae - MSc / The nearly oblate deformed Au nuclei show rotational bands built on multi quasiparticle excitations [Bou89, Bou92, Gue03, Gue01, Ven92]. Several of these bands are built on rotationally aligned high-j proton and neutron excitations. In many cases bands consisting of two or three signature partner E2 sequences are observed. For some fo these bands signature inversion is found and this feature gives a great challenge to the theoretical models. In this study the researcher performed TRS and CSM calculations for all high-j rotational bands in the p186-194s Au nuclei aiming to predict the signature splitting and inversion phemomena, alignments, gains in alignments, gains in alignment and band crossing frequencies observed. / South Africa

Title: Study of jet production in nucleus-nucleus collisions at RHIC Author: Mgr. Zuzana Barnovská Department: Institute of Particle and Nuclear Physics Supervisor: RNDr. Jana Bielčíková, Ph.D., Nuclear Physics Institute of the ASCR Abstract: The goal of this thesis is to study strange particles (Λ, ¯Λ a K0 S) in jets at the energy of √ sNN = 200 GeV in d+Au and Au+Au collisions measured by the STAR experiment at RHIC in 2007 and 2008. After the application of geometrical and topological limits, jets were reconstructed with the kT and anti- kT jet algorithms and special selection criteria for strange particles were applied. Ratios of the production of strange baryons and mesons in jets were calculated and compared to previous results of inclusive V0 particle production measured by the STAR experiment. Study of centrality dependence of these ratios was performed and compared to values in d+Au collisions. Keywords: jets, d+Au collisions, Au+Au collisions, STAR, RHIC 1

Este trabalho tem como objetivo principal a utilização da técnica “bottom-up" para a construção de nanoestruturas de ouro por meio de técnicas voltamétricas sobre uma superfície de Carbono Vítreo. Estas estruturas foram caracterizadas por métodos microscópicos e voltamétricos. A dimensão crítica das nanoestruturas foi obtida por meio de uma curva Gausseana de distribuição de alturas e diâmetros, fornecendo um valor médio de 35 nm por 150 nm de diâmetro. As nanoestruturas obtidas foram modificadas pela deposição de uma camada automontada de cistamina (um tiól), resultando num substrato adequado para futuras aplicações como a imobilização de enzimas. Os comportamentos eletroquímicos da dopamina e do ácido ascórbico, sobre eletrodos de ouro, Carbono Vítreo e Nanoestruturado, foram avaliados para a caracterização das modificações dos eletrodos. A diferença dos potenciais de pico de oxidação do AA sobre eletrodos de Carbono Vítreo e de ouro, de cerca de 300 mV, possibilitou avaliar o recobrimento do Carbono Vítreo com nanoestruturas pela diminuição da corrente de pico. Já a dopamina foi utilizada neste trabalho para determinar a presença da camada automontada de cistamina sobre a superfície das nanoestruturas de ouro, uma vez que sua resposta voltamétrica mostra um deslocamento do potencial de pico quando realizada sobre Au e sobre Au modificado com a camada automontada. / The subject of this work is focused in the utilization of a “bottom-up" approach to develop an Au nanostructured electrodeposits on the glassy carbon surface by a voltammetric procedure. These Au nanostructures have been characterized either by microscopic and voltammetric techniques. The critical dimensions of nanostructures has been evaluated by a Gausean normal data distribution curve and presented, as results a mean height of 35 nm and a mean diameter of 150 nm. The Au nanostructures were further modified by the deposition of a cystamine (thiol) self-assembled monolayer, yielding a suitable substrate for enzyme immobilization, as a possible future application. The electrochemical behaviour of dopamine and ascorbic acid on gold, Glassy Carbon and nanostructures was studied aiming to characterize the modified electrode. The 300 mV shift in the oxidation peak potential for ascorbic acid on gold in relation to Glassy Carbon allows to calculate the nanostructure coverage factor by the peak current inhibition as 43%. Finally, dopamine was employed to detect the self assembled monolayer formation on the Au nanostructure through its voltammetric behaviour. The variation in the oxidation potential for DA on gold and self assembled monolayer was used as an indicator for such modification.

Th.--Sci.--Université de Strasbourg 1, 1985. / Bibliogr. p. 257-280.

Este trabalho tem como objetivo principal a utilização da técnica “bottom-up” para a construção de nanoestruturas de ouro por meio de técnicas voltamétricas sobre uma superfície de Carbono Vítreo. Estas estruturas foram caracterizadas por métodos microscópicos e voltamétricos. A dimensão crítica das nanoestruturas foi obtida por meio de uma curva Gausseana de distribuição de alturas e diâmetros, fornecendo um valor médio de 35 nm por 150 nm de diâmetro. As nanoestruturas obtidas foram modificadas pela deposição de uma camada automontada de cistamina (um tiól), resultando num substrato adequado para futuras aplicações como a imobilização de enzimas. Os comportamentos eletroquímicos da dopamina e do ácido ascórbico, sobre eletrodos de ouro, Carbono Vítreo e Nanoestruturado, foram avaliados para a caracterização das modificações dos eletrodos. A diferença dos potenciais de pico de oxidação do AA sobre eletrodos de Carbono Vítreo e de ouro, de cerca de 300 mV, possibilitou avaliar o recobrimento do Carbono Vítreo com nanoestruturas pela diminuição da corrente de pico. Já a dopamina foi utilizada neste trabalho para determinar a presença da camada automontada de cistamina sobre a superfície das nanoestruturas de ouro, uma vez que sua resposta voltamétrica mostra um deslocamento do potencial de pico quando realizada sobre Au e sobre Au modificado com a camada automontada. / The subject of this work is focused in the utilization of a “bottom-up” approach to develop an Au nanostructured electrodeposits on the glassy carbon surface by a voltammetric procedure. These Au nanostructures have been characterized either by microscopic and voltammetric techniques. The critical dimensions of nanostructures has been evaluated by a Gausean normal data distribution curve and presented, as results a mean height of 35 nm and a mean diameter of 150 nm. The Au nanostructures were further modified by the deposition of a cystamine (thiol) self-assembled monolayer, yielding a suitable substrate for enzyme immobilization, as a possible future application. The electrochemical behaviour of dopamine and ascorbic acid on gold, Glassy Carbon and nanostructures was studied aiming to characterize the modified electrode. The 300 mV shift in the oxidation peak potential for ascorbic acid on gold in relation to Glassy Carbon allows to calculate the nanostructure coverage factor by the peak current inhibition as 43%. Finally, dopamine was employed to detect the self assembled monolayer formation on the Au nanostructure through its voltammetric behaviour. The variation in the oxidation potential for DA on gold and self assembled monolayer was used as an indicator for such modification.

Le présent projet aborde l'étude du lien entre la qualité de la relation d'attachement et l'ouverture sur le monde du père auprès d'enfants âgés entre douze et trente-six mois. L'échantillon comprend 56 dyades père-enfant qui participaient à des ateliers de stimulation au CLSC. La sécurité d'attachement a été évaluée à l'aide du Q-Sort sur l'attachement de Waters et Deane (1995), l'ouverture sur le monde a été évaluée à l'aide du QOM (Paquette et al. , 2004) et le stress parental a été évalué à l'aide de la version abrégée de l'ISP (Abidin, 1990). En ce qui concerne l'objectif central de l'étude, les résultats ne démontrent pas de relation directe entre la qualité de la relation d'attachement père-enfant et son ouverture sur le monde, mais il y a présence d'effets significatifs entre le QOM et l'ISP ce qui suggère d'accorder plus d'attention à la conception actuelle du rôle du père sur le développement du jeune enfant.

Le Carcinome hépatocellulaire (CHC) est un cancer primitif du foie très agressif classé au second rang des cancers en termes de mortalité avec 810 000 décès en 2015. Actuellement, le Sorafenib, un inhibiteur multikinases, est le traitement de référence du CHC de stade avancé. Cependant, avec un taux de réponse objective de 2 à 3%, peu de patients répondent au traitement et lorsqu'ils répondent, l'émergence de résistance est rapidement observée après quelques mois de traitement. Récemment, notre équipe a identifié un récepteur, le SLAMF3, à la surface des hépatocytes et son rôle suppresseur de tumeurs dans le CHC. Durant cette thèse, nous avons démontré l'implication de la voie RB/PLK-1 dans l'inhibition de la prolifération induite par SLAMF3. De plus, SLAMF3 sensibilise les cellules cancéreuses de CHC au Sorafenib. En effet, l'induction de SLAMF3 inhibe l'expression et l'activité du transporteur MRP-1 impliqué dans la résistance aux traitements anti-cancéreux mais également diminue le phénotype pluripotent agressif mis en évidence dans la résistance acquise au Sorafenib. Afin d'induire le rôle suppresseur de tumeurs de SLAMF3 chez les patients, nous avons mis en évidence le rôle de l'histone déacétylase 2 dans la perte d'expression de SLAMF3 dans les cellules cancéreuses. De plus, SLAMF3 est également exprimé dans les tissus bronchiques, colorectaux et mammaires. Comme dans le CHC, l'expression de SLAMF3 est diminuée dans ces différents cancers. Nos résultats suggèrent que l'induction de SLAMF3 par l'inhibition des histones déactylases serait une stratégie thérapeutique potentielle dans la prise en charge des cancers solides et plus particulièrement du CHC / Hepatocellular carcinoma (HCC) is the most important liver cancer and is the second-one in cancer-related death with 810,000 deaths in 2015. Currently, Sorafenib, a multikinases inhibitor, is standard treatment for advanced HCC. However, with an objective response rate of 2-3%, only few patients respond to Sorafenib and when patients respond, Sorafenib resistance is observed after some months. Recently, our team has identified a receptor, SLAMF3, at hepatocytes cell surface and its tumor suppressor role in HCC. During this thesis, we demonstrate implication of RB/PLK-1 pathway in cell proliferation inhibition by SLAMF3. Moreover, SLAMF3 sensitizes HCC cancer cells to Sorafenib. Indeed, SLAMF3 overexpression decreases expression and activity of MRP-1, a transporter implicated in anti-cancer treatment resistance, and also reduces the pluripotent aggressive phenotype highlighted in acquired-resistance to Sorafenib. To induce the tumor suppressor role of SLAMF3, we highlight implication of histone desacetylase 2 in loss of SLAMF3 expression in HCC cancer cells. To finish, SLAMF3 is also expressed in pulmonary, colorectal and mammary tissues. As observe in HCC, SLAMF3 expression is decreased in these different cancers. We describe, particularly, inhibition of cell migration by SLAMF3 by reducing Ca2+ influx in mammary cancer cells. Our results suggest a new therapeutic strategy based on SLAMF3 expression induction by histone desacetylase 2 inhibition in solid cancers treatment, and more particularly in HCC

none

Texte remanié de: Honours thesis--Boston--University of Massachussetts. / Bibliogr. p. 127-137. Index.