The pursuit of new opportunities is at the heart of entrepreneurship. Creating the organizational environment to recognize and seize such opportunities is fundamental to entrepreneurial success and yet, the relationship between organizational design and entrepreneurship has received limited attention. Drawing on extant research in the fields of corporate venturing, technology business incubation, organizational design and governance, this dissertation addresses these research gaps by presenting four studies. The first relies on abductive reasoning to develop a conceptual framework for typologizing the design of the heterogeneous accelerator phenomenon. The second study empirically develops an organizational design typology of various corporate accelerator archetypes, as a key mechanism for the process of technology business incubation and corporate venturing. It further highlights how corporate accelerator design evolved over time. The third study addresses organizational decision systems and specifically, the role of the board of directors in young, entrepreneurial ventures. The fourth study presents a case study and teaching note exploring how to design an entrepreneurial organization and sustain its flexibility, adaptability and entrepreneurial DNA over the long term. In sum, this dissertation contributes to the field of entrepreneurship by extending prevailing knowledge on the why, how, and what of corporate accelerators, new venture boards and the organizational design behind such entrepreneurial entities.