This diploma thesis focuses on the care for persons with AD and the limits of care for these persons in a regular program facility. For several years already, the life expectancy has been increasing. However, this relates to the fact of increasing number of people suffering from diseases connected especially with the end of one's life, AD being no exception. This diploma thesis consists of theoretical and empirical parts. The aim of the theoretical part was to study and then analyse professional literature related to the topic. The theoretical part of the thesis is divided in three chapters. The main aim of the thesis was to find out, whether regular program facilities are capable of taking care of a client with dementia. Partial aims were to discover in which areas the employees of the regular program facility feel the strain while taking care of a person with dementia and how this client is perceived by other clients. While collecting data for the empirical part of the thesis, qualitative survey, inquiry and semi-structured interview were used as the methods of choice. The prepared questions were divided in five groups, making a total of 32. Through the survey I've found the regular program facilities able to take care of clients with AD. Since living together of clients with and without AD is possible, although problematic, it burdens the caring personnel, who see the most common problem in the regular program facility in a lack of time for clients, for taking care of them and communicating with them, and also in a small number of staff compared to the number of clients. According to my survey, the employees of a regular program facility mostly perceive situations connected with changing behaviour of clients with AD as stressful. This includes wandering of clients, their aggressiveness, the need of a different daily regime of a client with AD (sleep, diet) and complains on the behaviour of clients with AD from those without the disease. The employees are also under stress from the communication with clients with AD. I've also learned that clients without AD, according to the caring staff, perceive the clients with AD as problematic, they know that those receive more attention from the personnel and some clients with AD disturb other clients. However, living together of both groups is possible. I suppose that the number of patients with AD plays a part here, while it's not high in a regular program facility, and therefore clients with AD don't disrupt business as usual in the facility. From the empirical part of the thesis, following hypothesis can be made: The regular program facilities will take care of the clients with AD better, when the number of caring staff increases. The suggested hypothesis needs to be verified through a higher number of respondents. I assume that this thesis can serve as a source of information to both lay public and experts in the field of care for persons suffering from AD.

The basal ganglia (BG) are a group of brain nuclei situated deep in the cerebral hemispheres. While BG were primarily associated with motor functions, in recent years there has been an increasing evidence that BG are also significantly involved in a wide range of non-motor functions. This work focused on some of the non-motor symptoms associated with two typical basal ganglia disorders: Parkinson's disease (PD) and Huntington's disease (HD). The first study concerned spatial navigation impairment in patients with HD. Their spatial navigation skills were tested using the Blue Velvet Arena, technique evaluating spatial navigation in real space, capable to selectively differentiate between two components of spatial navigation - allocentric (environment-oriented) and egocentric (self-oriented). Allocentric navigation is linked to hippocampal function, whereas egocentric navigation is usually associated with striatum, a structure predominantly affected in HD. We found that spatial navigation is not significantly affected in the early stages of HD and that in more advanced stages, when spatial navigation is already impaired, there is no significant difference between allocentric and egocentric navigation impairment. We speculate that the striatal involvement does not contribute to the impairment of the...

84 Abstract Main theme of this diploma thesis is notice of termination of employment, in particular by the employer. The goal is to fully describe and analyze legal institution of notice. At first the Czech legal regulation is described, then it deals with a regulation of notice of termination according to the Peruvian legal system. The emphasis is put on notice of termination in Peru by the employer and aim is taken at comparing both laws and propose possible future reciprocal inspiration. The thesis is divided into five chapters, the first chapter focuses on labor law, its conception, function and origin, employment as such and describes possible methods of its termination (agreement on termination of employment, summary dismissal, summary dismissal during trial period, termination on the basis of official decision, termination following legal event). The second chapter elaborates the notice of termination with emphasis on termination by the employer according to Czech law, its formal requirements, its proper delivering, reasons for termination, prohibition of termination on period of protection and applicable exceptions. The third chapter is about labor law in Peru in general, about employment, its elements, termination options and development of job security. The fourth chapter is dedicated to the...

This thesis deals with the development of social insurance, specifically with health insurance and social security, from the standpoint of transfer of insurance-generated monies to the state budget. It presents the significance of social insurance in its current form and an analysis of the principal changes it has undergone in the last fifteen years. It particularly examines changes in the definition of participants in social insurance and changes in the use and structure of bases of measurement in individual insurance subsystems. This thesis also includes an analysis of these changes which seeks to analyze the past and potential impact of shifts in basic factors which influence the amount of money flowing from insurance to the state budget (such as minimum wage, average wage and number of paying participants) on individual participants in social insurance.

<p>Karcinom debelog creva predstavlja treći uzrok smrnosti od maligniteta kod mu&scaron;karaca i drugi kod žena. Postoji osnovana sumnja da kancerske matične ćelije (KMĆ) imaju veliki značaj u karcinogenezi, invazivnosti, &scaron;irenju i rezistenciji na hemioterapiju primarnog tumora. Njihova identifikacija u primatnom kolorektalnom karcinomu (KRK) putem markera kancerskih matičnih ćelija bi selektovala visokorizičnu grupu bolesnika, omogućila ciljano delovanje na ove ćelije i veću &scaron;ansu za izlečenje. Cilj ovog istraživanja je bio utvrđivanje uticaja prisustva kancerskih matičnih ćelija u primarnom tumoru obolelih od karcinoma kolona na pojavu relapsa bolesti, dužino preživljavanja bez bolesti i sveukupno preživljavanje.&nbsp; Istraživanje je sprovedeno kao prospektivno&minus;retrospektivna randomizovana analitička studija na Klinici za operativnu onkologiju i Službi za patolo&scaron;ko &ndash; anatomsku i laboratorijsku dijagnostiku Instituta za onkologiju Vojvodine u Sremskoj Kamenici u periodu od 2016-2019. godine. U studiju su uključeno 112 bolesnica operisanih na Institutu za onkologiju Vojvodine u periodu od 2007-2012. godine sa patohistolo&scaron;ki potvrđenom dijagnozom primarnog, nemetastatskog (stadijumi I, II i III) KRK. Bolesnici su randomizovani u odnosu na pojavu recidiva bolesti i prisustvo metastaza u regionalnim limfnim čvorovima u odnosu 1:1. Uzorci tumorskog tkiva dobijeni hirur&scaron;kom resekcijom su nakon standardne patohistolo&scaron;ke obrade tretirani primenom monoklonskih antitela na CD44, CD166 i &alpha;-Lgr5. Određivani su prisustvo, intezitet i lokalizacija kancerskih matičnih ćelija (KMĆ) u primarnom tumoru i njihov uticaj na pojavu relapsa bolesti, dužinu preživljavanja bez bolesti i sveukupno preživljavanje u grupi svih bolesnika a potom bolesnika podeljenih prema stadijumu bolesti. Bolesnici u prvom i drugom stadijumu bolesti koji su imali relaps su imali statistički značajno veće prisustvo CD44+ KMĆ u primarnom tumoru. Kod ovih bolesnika je prisutan kraći period preživljavanja bez bolesti kao i kraće sveukupno preživljavanje. Takođe, uočen je statistički značajan uticaj koekspresije CD44/CD166 u KMĆ na pojavu relapsa bolesti, dužinu preživljavanja bez bolesti i sveukupno preživljavanje kod bolesnika u prvom i drugom stadijumu bolesti. Nije uočena statistička značajnost prisustva KMĆ u primarnom tumoru na pojavu relapsa bolesti, dužinu preživljavanja bez bolesti i sveukupno preživljavanje kod bolesnika u trećem stadijumu bolesti. Prisustvo CD166 i &alpha;-Lgr5 obojenih KMĆ nije pokazalo statističku značajnost u pogledu pojave relapsa bolesti, dužine preživljavanja bez bolesti i sveukupnog preživljavanja, kako u grupi svih bolesnika tako i prilikom podele bolesnika na stadijume bolesti.</p> / <p>Colon cancer is the third most common case of death of malignancy in the world. There is justified theory that cancer stemm cells have significant impact on colon cancer tumorogenesis, invasiviness, spread and resistancy on chemotherapy. Identification of colon cancer stem cells in primary tumor by various biological markers would lead to identification of high risk group of patients, target therapy of colon cancer an higher chance to cure. Aim of this study was to determine wether presence of colon cancer stem cells in primary tumour have impact on recurrence, disease free survival (DFS) and overall survival (OS) in patients with colorectal cancer. An randomized, analytical prospective-retrospective study was performed on Clinic for Operative Oncology and Department for Anatomical Pathology of Oncology Institute of Vojvodina in Sremska Kamenica in period of 2016&minus;2019. Study included 112 patient with patohistological proven, non metastatic colon adenocarcinoma who were operated on Oncology Institute of Vojvodina in period of 2007-2012. Patients were randomized by recurrence and presence of metastatic lymph nodes by 1:1 ratio. After standard patohistological preparation, tumour specimens were stained for monoclonal CD44, CD166 and &alpha;-Lgr5 antibody. Presence, intensity of expression and localization of colon cancer stem cells were observed and their impact on relapse, disease free survival and overall survival in group of all patients as well as in groups divided by stages of the disease. We demonstrate that patients in Stage I and II of the disease who experience disease recurrence have statistically significant higher expression of CD44+ in primary tumor specimen. They also have shorter DFS and OS. Coexpression of CD44/CD166 antibody also have strong negative impact on recurrence, disease free survival and overall survival in Stage I and II patients. There is no correlation between presence of colon cancer stem cells and recurrence nor presence of colon cancer stem cells had impact on disease free survival and overall survival. Presence of CD166 and &alpha;-Lgr5 expression did not show significant impact on recurrence nor disease free survival and overall survival as in group of all patients as well in group of patients divided by stages of the disease. High expression of CD44+ and coexpression of CD44/CD166+ colon cancer stem cell markers in primary tumor specimen correlates with higher chance for disease recurrence and also leads to shorter DFS and OS.</p>

The diploma thesis deals with the design of concrete structures reinforced by FRP according to ACI, fib, CSA and EC2 regulations, which are stressed by a shear force. The diferences between steel rebar and FRP reinforcement were described, in particular its mechanical degradation over time and a different stress-strain diagram. Furthermore, shear capacity calculations were performed according to the regulations and compared with the real tests. Then the parametric analysis of shear strength was performed. In the practical part, the design of concrete floor slab structure supported by the pillars and walls was performed. The upper reinforcement of this slab was designed with FRP and the lower with steel rebar. Double-headed studs were used as a punching shear reinforcement.

The project documentation, processed in the framework of the diploma thesis, solves the new building of the administrative building of the building company in the village Lukov u Moravských Budějovic. The building is made of traditional brick technology therm tl. 50 cm, without insulation, ceilings are reinforced concrete, flat roof, vegetation. Vegetation is also part of the facade of the building, which at the same time serves as a root cleaner. The philosophy of the whole design is to create a high-quality working environment for building company employees, a pleasant environment for customers and to best solve the environmental footprint of the building. The building is designed as a modern office building, with space for leisure activities of staff and their visits, taking into account the responsible approach to the development industrial site and the surrounding nature. The building efficiently manages potable, rain and wastewater, the envelope of the building, and the individual structures are designed to make the entire building as energy-consuming as possible, and do not pump irreparably by nature its natural resources in a larger quantity than necessary.

Diploma thesis is focused on structural assessment and strengthening of the reinforced concrete flor slab disturbed by excessive deflection. Thesis included assesment of the existing construction and design method of strengthening of the floor structure with system using prestressing strands without bond.

The masters thesis is about operational testing on selected constructions of a railway track „in situ“. There were selected two sections with and without under sleeper pads on a railway track for measurement. These measurements were evaluated then. The result is an assessment of the suitability or unsuitability for under sleeper pads for a rail transport.

The final thesis deals with strengthening of cast-in-place concrete ceiling in existing construction for couple of escalators. New prestressed beam, columns in new positions and strengthened girder with unbonded strands are building in this adjustments. Every member, including the existing construction, is verified for ultimate and serviceability limit state. Prestressed members are alternatively designed with bonded strands and these variants are comparison in terms of utilization and calculation.