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Process simulation and optimisation of high pressure distribution for the release of intracellular proteinsSiddiqi, Somaiya Fatima January 1998 (has links)
No description available.
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Modeling and simulation of mass transfer in airlift fermentorsHo, Chester January 2011 (has links)
Digitized by Kansas Correctional Industries
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Fundamentals and application of metabolic engineering /Wong, Kelvin Wai Wah. January 2006 (has links)
Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2006. / Includes bibliographical references (leaves 228-239). Also available in electronic version.
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A two-stage reduction for complex combustion chemistryHuynh, Phong Tien. January 2008 (has links)
Thesis (M.S.)--Rutgers University, 2008. / "Graduate Program in Chemical and Biochemical Engineering." Includes bibliographical references (p. 64-67).
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A STUDY OF POLYMER-SMALL MOLECULE INTERACTIONS FOR SOLID-LIQUID TWO PHASE PARTITIONING BIOREACTORS WITH EMPHASIS ON THE BIOPRODUCTION OF 2-PHENYLETHANOLGAO, FANG 02 July 2009 (has links)
Biphasic systems have been studied for in situ product removal (ISPR), and have shown improvements in bioreactor performance. With immiscible solvents, concerns associated with solvent biocompatibility, bioavailability and operation have been identified. One alternative is a solid-liquid system in which polymer beads are used, absorbing and removing target compounds from the aqueous phase while maintaining equilibrium conditions. In such systems, the capability of a polymer to absorb the compound of interest is an important parameter. This work has identified polymer properties that may be important to the interaction between polymers and target compounds for selected biotransformation molecules including 2-phenylethanol, cis-1,3-indandiol, iso-butanol, succinic acid and 3-hydroxybutyrolactone. Furthermore, the biotransformation from L-phenylalanine to 2-phenyethanol, an important aroma compound in industry, was examined in detail.
It was found that relatively hydrophobic compounds tend to be absorbed by polymers better than hydrophilic ones based on partition coefficient tests. Since all of the biotransformation molecules tested have polar functional groups such as alcohol, acid and lactone, polar polymers such as Hytrel® performed better than non-polar polymers such as Kraton® possibly due to the hydrogen-bonding interaction between the polymer and the solute. Crystallinity and intermolecular hydrogen-bonding were also found to be important polymer properties.
Hytrel® 8206 was identified as the best working polymer to absorb 2-phenylethanol. A solid-liquid batch mode two phase partitioning bioreactor (TPPB) with 500 g Hytrel® generated an overall 2-PE concentration of 13.7 g/L, the highest reported in the current literature. This was based on a polymer phase concentration of 88.74 g/L and aqueous phase concentration of 1.2 g/L. Better results were achieved via contact with more polymers with the aqueous phase applying a semi-continuous reactor configuration. In this system, a final 2-PE concentration (overall) of 20.4 g/L was achieved. The overall productivities of these two reactor systems were 0.38 g/(L-h) and 0.43 g/(L-h), respectively. This experiment successfully demonstrated that with the appropriate selection of polymer, solid-liquid TPPB systems were able to greatly enhance bioproductions associated with end product inhibition in terms of final product concentration and productivity. The ease of operation is also attractive compared to two liquid phase systems. / Thesis (Master, Chemical Engineering) -- Queen's University, 2009-07-02 11:37:33.83
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Novel sustainable solvents for bioprocessing applicationsKassner, Michelle Kimberly. January 2008 (has links)
Thesis (Ph. D.)--Chemical Engineering, Georgia Institute of Technology, 2009. / Committee Co-Chair: Eckert, Charles; Committee Co-Chair: Liotta, Charles; Committee Member: Bommarius, Andreas; Committee Member: Fernández, Facundo; Committee Member: Lu, Hang. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Biocatalytic conversion of vanillin to 3-carboxy muconateGosling, Aaron. January 2009 (has links)
Thesis (PhD) - Faculty of Life and Social Sciences, Swinburne University of Technology, 2009. / Submitted for the degree of Doctor of Philosophy, [Faculty of Life and Social Sciences], Swinburne University of Technology - 2009. Typescript. Includes bibliographical references (p. 210-227)
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The solubilization of mitochondrial protein by nonionic surface active agentsSwain, Louis Martin. January 1966 (has links)
LD2668 .T4 1966 S971 / Master of Science
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Analysis of single nucleotide polymorphisms using molecular affinity separation and mass spectrometryMisra, Ashish, January 2009 (has links)
Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Chemical and Biochemical Engineering." Includes bibliographical references (p. 73-78).
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The development and application of chemometrics to process analysis in an industrial environmentMoffatt, James January 1999 (has links)
This thesis describes two main sections of work, an examination of a commercial product, Intrasite Gel, and the development of an algorithm for variable selection using projected latent structures.Following on from the successful development of a variable selection procedure for multivariate linear regression this work looks at transferring this idea for use with projected latent structures. The first part of this thesis will show how the variable selection algorithm was developed and used with three different data sets. The algorithm will be shown to be superior to standard projected latent structures, for linear multi-component data. Although the final algorithm developed requires considerable computing resources to carry out this is compensated for by significantly improved model predictions and robustness. The final algorithm developed is written to run using MATLAB on any computer platform that supports this application, though the principles of operation could be transferred to another method of execution, for example custom code written in C or Pascal. The approach used in the development of this method is that the ability of the model to predict unknownsamples is of far greater importance than the internal performance of the model. All the assessments of the procedures developed are based on the ability of the model to predict accurately and precisely samples that were not presented to the model during the training stage.The second section of this thesis is concerned with the study of Intrasite Gel, produced by Smith & Nephew Ltd. Hull. The material in question is a medical device intended to assist in the treatment and healing of wounds that are necrotic, sloughy or granulating. The product is characterised by its ability to maintain moisture equilibrium in a wound environment and to provide a suitable medium to encourage the growth of new cell tissue. Medical devices require registration, and as part of that registration a number of tests are made on samples to ensure that the material meets the required specifications. There was some concern at Smith & Nephew that the tests they were required to carry out as part of the device registration were not providing appropriate information about the product. Of particular interest was the fluid absorption property as it was suspected that the test has a large amount of random error associated with it and an investigation was required to examine this test and to provide an alternative procedure should the fluid absorption test prove inadequate. Also of interest to Smith & Nephew was the issue of sampling frequency, as it was felt that this should also be examined to determine whether the correct rate of sampling to ensure product quality was being carried out. The work reported here shows that the fluid absorption test as it stands is insufficient to the task of monitoring this property of Intrasite gel and that an alternative test should be considered. This work also showed that current sampling rate was too high and that the high sampling rate may in fact cause misleading assumptions as to the stability and quality of the product.
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