Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Lucie Bahenská Supervisor: doc. MUDr. Bohuslav Matouš, CSc. Title of diploma thesis: Monitor the parameters of thyroid function with regard to a diagnosis of hypothyroidism in middle aged There was proved an occurence of the thyroid disorders with regard to hypothyreosis in humans in the middle age in the file of 15 412 patients (5753 men, 9659 women). Simultaneously there was calculated an occurence of these disorders in the rate on men vs women. There was a file of all patients examined in VFN during the year 2012 including all patients treating at the department of endocrinology. No significant higher occurence of thyroid disorders at women was found. In the examined file there were 474 TSH analysis indicated by a practitioners like a steering control. There wasn't confirmed a higher incidence of an occurence of the thyroid disorders at women. In the file indicated by practitioners there was changed the value of TSH at 7,2% women and 9,9% men. The reason can be caused by examination the men in the risk group in comparison to women, who are examined without risk factors. There was checked the connection between hypothyreosis and diabetes mellitus and no significant higher occurence...