<p>Generalni cilj ovog istraživanja je da se utvrdi da li postoji uticaj primenjenog<br />programa vežbanja na parametre ko&scaron;tane gustine i biohemijske markere ko&scaron;tanog<br />remodelovanja kod žena u periodu premenopauze i postmenopauze.<br />Uzorak ispitanica je činilo 26 žena starosti 45 do 55 godina, od kojih su 13 u periodu<br />premenopauze, a 13 u periodu postmenopauze. Ispitanice su učestvovale u programu vežbanja<br />u trajanju od 6 meseci, koji se realizovao u Novom Sadu, 4 puta nedeljno u trajanju od sat<br />vremena. Za utvrđivanje uticaja programa vežbanja na ko&scaron;tanu gustinu merena su 3<br />osteodenzitometrijska parametra na kičmi, vratu butne kosti i kuku i 5 parametara<br />biohemijskih markera ko&scaron;tanog remodelovanja.<br />Da bi se utvrdio uticaj vežbanja kod ispitanica, primenjena je multivarijatna analize<br />varijanse (MANOVA). Na celokupnom uzorku ispitanica nije utvrđena statistički značajna<br />razlika ni u jednom merenom parametru ko&scaron;tane gustine. U odnosu na biohemijske markere,<br />do&scaron;lo je do značajnog smanjenja nivoa ukupne alkalne fosfataze. Kod žena u periodu<br />premenopauze i kod žena u periodu postmenopauze, program vežbanja nije značajno uticao<br />na parametre ko&scaron;tane gustine merene na kičmi, vratu butne kosti i kuku (DXA, Lunar<br />Prodrigy), kao ni na parametre biohemijskih markera ko&scaron;tanog remodelovanja.<br />Primenom multivarijatne analize kovarijanse (MANCOVA) utvrđena je značajna<br />razlika u uticaju programa vežbanja između žena u pre- i postmenopauzi u mineralnoj<br />ko&scaron;tanoj gustini vrata butne kosti (BMD VF) i markera beta-crosslaps (CTX). Mineralna<br />ko&scaron;tana gustina je nakon programa vežbanja veća, a nivo beta-crosslapsa niži kod žena u<br />premenopauzi nego kod žena u periodu postmenopauze.<br />Na osnovu dobijenih rezultata, zaključujemo da je potreban duži vremenski period<br />realizacije programa vežbanja kako bi se mogla primetiti statistički značajna promena<br />merenih parametara. Ispitanicama se savetuje da nastave sa vežbanjem kako bi usporile<br />gubitak kosti</p> / <p>The genaral aim of this research is to determine is there an effects of the applied exercise<br />program on bone mineral density and and biochemical markers of bone turnover in the<br />premenopausal and postmenopausal period.<br />The sample was consisted of 26 women aged 45 to 55 years, of which 13 were in<br />premenopausal and 13 in postmenopausal period. Subjects were included (had performing) in 6-month<br />exercise program, which was implemented (maintained) in Novi Sad, 4 times a week in duration for an<br />hour. Three osteodensitometric parameters on lumbar spine, femoral neck and hip (DXA, Lunar<br />Prodrigy) and five parameters of biochemical markers of bone turnover were measured to assessed<br />(to determine) the effects of exercise program on bone density.<br />Multivariate analysis of variance (MANOVA) was used to determine the effect of exercise.<br />For the entire sample of subjects, there were no statistically significant difference in any measured<br />bone density parameter, but looking at biochemical markers, total alkaline phosphatase level were<br />significanly reduced. There were no significant changes in bone density parameters on the lumbar<br />spine, femoral neck and hip nor on the parameters of biochemical markers of bone turnover in women<br />in premenopausal and postmenopausal period.<br />Applying multivariate analyse of covariance it was found a significant difference in the<br />exercise program effect between pre- and postmenopausal women in bone mineral density of femoral<br />neck (BMD VF) and beta-crosslaps marker of turnover (CTX). Femoral neck BMD was higher, and<br />beta-crosslaps level was lower in premenopausal women than in postmenopausal women after<br />completion exercise program.<br />Based on obtained results, we conclude that is required a longer perod of exercise program<br />ralization in order to notice a statistically significant change in measured parameters. Subjects are<br />advised to continue their exercising in order to slow down the bone loss</p>