• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 1
  • Tagged with
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Avaliação das complicações hematológicas e renais e do risco tromboembólico de cães com AHIM

Moraes, Lívia Fagundes [UNESP] 11 July 2011 (has links) (PDF)
Made available in DSpace on 2014-06-11T19:27:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-11Bitstream added on 2014-06-13T19:14:30Z : No. of bitstreams: 1 moraes_lf_me_botfmvz.pdf: 428197 bytes, checksum: bc0cb7abb11b1fca9cd1b81b73ec75e5 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A anemia hemolítica imuno-mediada (AHIM) é a causa mais comum das anemias hemolíticas e tem sido associada a estados de hipercoagulabilidade. Neste trabalho objetivou-se: avaliar a ocorrência de alterações hematológicas, hemostáticas e renais e a prevalência das classes de imunoglobulinas (Ig) envolvidas nas AHIM. 87 cães anêmicos foram submetidos ao teste de Coomb’s, citometria de fluxo (CF) e auto-aglutinação, além de hemograma e contagem de reticulócitos, perfil hemostático e renal, pesquisa de hematozoários e testados para Ehrlichia sp e leptospirose. Os resultados foram analisados pelo teste t, Mann-Whitney ou Kruskal-Wallis ao nível de 5% de significância. 61 cães (70,11%) foram positivos para AHIM na CF, 31 (35,63%) para o Coomb’s e 24 (27,58%) para auto-aglutinação. Não houve predomínio de uma classe de Ig envolvida. As alterações clínico-laboratoriais para cães com AHIM incluíram anemia regenerativa, macrocítica, hipocrômica e reticulocitose, além de icterícia, febre, hiperglobulinemia e bilirrubinúria. 9,8% dos cães positivos apresentaram esferocitose, 29,5% leucocitose, 39,6% neutrofilia e 72,1% trombocitopenia. A proteinúria e o aumento na relação proteína: creatinina urinárias revelam indícios de lesão renal. Os cães anêmicos positivos e negativos para AHIM apresentaram diferença estatística em relação ao grupo controle para contagem de plaquetas, TP, TTPA, AT, PDF e Dímeros D. 25 cães positivos e sete cães negativos para AHIM apresentaram um estado tromboembólico. Estas alterações hemostáticas podem ser atribuídas à causa base predominante para a anemia em questão, uma vez que 74,6% dos casos de AHIM foram atribuídos às doenças infecciosas, a maioria associados à Ehrlichia sp / Immune-mediated hemolytic anemia (IMHA) is the most common cause of hemolytic anemia and has been associated with hypercoagulable states. The objectives of this study were: to evaluate the incidence of hemostatic, renal and hematological abnormalities, and the prevalence immunoglobulin’s classes involved in IMHA. 87 anemic dogs were selected and submitted to Coomb’s test, flow cytometry (FC) and auto-agglutination, along with CBC, reticulocyte count, hemostatic and renal profile, hemoparasite search in peripheral blood smears, and Ehrlichia sp and leptospirosis tests. The results were analyzed by t test, Mann-Whitney or Kruskal-Wallis at 5% of significance. 61 dogs (70.11%) were positive to IMHA by CF, 31 (35.63%) by Coomb's test and 24 (27.58%) by auto-agglutination. There wasn’t a predominance of IgG or IgM involvement. The hematological and clinical changes in dogs with IMHA included macrocytic, hypochromic regenerative anemia, and reticulocytosis, as well as icterus, fever, auto-agglutination, hyperglobulinemia and bilirubinuria. 9.8% of dogs with IMHA had spherocytosis, 29.5% leukocytosis, 39.6% neutrophilia and 72.1% thrombocytopenia. Proteinuria and the increase in urine protein creatinine ratio reveal evidences of renal injury. There were statistical differences between the control group and anemic dogs positive or negative for IHMA to the following tests: platelet count, PT, APTT, AT, FDP and D-dimer. 25 positive dogs and seven negative dogs for IMHA were in a thromboembolic state. These hemostatic changes observed in both groups of anemic dogs may be attributed to the predominant underlying cause of anemia, since 74.6% of IHMA cases were attributed to infectious diseases; mostly Ehrlichia sp related

Page generated in 0.0523 seconds