MSc (Occupational Therapy), Faculty of Health Sciences, University of the Witwatersrand / Ergonomic interventions, addressing work and lifestyle factors, seem more effective in reducing computer related upper limb repetitive strain injury (RSI).This study considered the efficacy of such a programme on the resolution of RSI symptoms. A cross sectional survey, of 325 computer workers in a medical aid company call centres, in Gauteng, South Africa was used to establish a point prevalence of 30.23% for RSI symptoms, which correlates with those found elsewhere. An occupational therapy ergonomic intervention was then designed and piloted for efficacy. A randomised control trial conducted on 37 participants with RSI used the programme and computer generated “Break Software”. The six week intervention included the assessment of: three physical outcome measures and lifestyle factors for, the experimental and control groups. Results indicated positive effects on pain, grip strength, and lifestyle factors including feelings of inefficiency, pressure at the end of the day, depression and work capacity, but little extrapolation of ergonomic knowledge to the workplace.