M.Sc. (Chemistry) / A new method has been developed for the conversion of carbohydrate vicinal diols into the corresponding glycal derivatives. Treatment of suitably protected furanose 1,2-diols with mesyl chloride and triethylamine in anhydrous 1,2-dirnethoxyethane resulted in the formation of 2-0-mesyl-furanosyl chlorides. Reductive elimination of the latter with excess active zinc dust in the presence of iodide furnished furanoid glycals ...

Thesis (doctoral)--Lund University, 1996. / Added t.p. with thesis statement inserted.

Thesis (Ph. D.)--Columbia University. / Includes bibliographical references (p. 24-26).

Thesis (doctoral)--Lund University, 1996. / Added t.p. with thesis statement inserted.

Thesis--Wisconsin. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1983. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

(M.S.)--Villanova University, 2007. / Chemistry Dept.

Dimethyl sulphate has been used for carbohydrate methylation under various conditions of concentration, time and alkalinity in order to determine optimum reaction conditions. Mesquite gum was used as a representative water-soluble polysaccharide. / Science, Faculty of / Chemistry, Department of / Graduate

The synthesis of organometallic derivatives of carbohydrates was approached in two different ways. The first method was nucleophilic attack by vitamin B₁₂s, cyclopentadienyl iron dicarbonyl and cyclopentadienyl tungsten and molybdenum tricarbonyl anions on the carbohydrate sulphonate in an attempt to synthesise direct metal linkage to the carbohydrate via a carbon metal bond. The reaction was found to be most successful when applied to primary carbohydrate sulphonates. Little success was encountered with secondary tosylates arid epoxides. The main problem enountered here was the difficulty in isolating the organometallic derivatives. Another series of compounds were synthesised in an attempt to extend this study of metal derivatives of carbohydrates, to metal-carbohydrate derivatives bonded through a heteroatom. Model systems were studied of six-membered thio complexes of tungsten, manganese and platinum. From the tungsten and manganese complexes it was found that the tungsten complex was 'locked' only by a t-butyl system, whereas the manganese complexes appeared to be 'locked' even without the t-butyl group. The six-membered rings in each case appeared to be puckered chairs. The configuration about the sulphur was not determined, although it appears to be either the diequatorial configuration, or a fast equilibrium between the axial-equatorial⇄diequatorial⇄equatorial-axial configurations. Studies on the platinum thio complexes indicate that for a six-membered ring, the average coupling constant of Pt-S-C-H was 58 Hz, while the trans coupling of platinum through sulphur was found to be at least 73 Hz, with J[formula omitted] + J[formula omitted] = 120 Hz. / Science, Faculty of / Chemistry, Department of / Graduate

At the turn of this century the form in which ingested protein was absorbed from the intestine was unknown. Voit had postulated in 1867 that protein was absorbed as such, and passed through the blood to the tissues, where it was oatabolised without becoming part of the "living protoplasm". This concept implied that "circulating protein" was in solution, that protein catabolim could take place only in that state, and that when living protoplasm "died", it was first dissolved, and subsequently became part of the circulating protein derived from the food.