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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Caractérisation et régulation des régimes de cavitation ultrasonore pour la sonoporation cellulaire / Characterization and control of the regimes of ultrasonic cavitation for cells sonoporation

Cornu, Corentin 03 July 2018 (has links)
Dans l’objectif de limiter les effets destructeurs de l’implosion de bulles de cavitation ultrasonore, un régime d’oscillations stables de bulles doit potentiellement être visé pour des applications thérapeutiques sensibles comme l’ouverture de la barrière hémato-encéphalique. Cependant, garantir une activité d’oscillations stables est difficile de par le caractère stochastique de la cavitation ultrasonore, et de la coexistence de bulles oscillantes (cavitation stable) et implosantes (cavitation inertielle) au sein d’un nuage de bulles. Il est donc nécessaire de contrôler spatialement et temporellement le phénomène de cavitation en discriminant les régimes de cavitation stable ou inertielle, au cours de la durée d’un tir ultrasonore, et ce en régime pulsé. Dans une première étude, la dynamique d’un nuage de bulles monodisperses et uniformément réparties dans l’espace met en évidence l’effet de l’interaction entre bulles sur le seuil de cavitation stable : il s’abaisse en pression et la fréquence de résonance des bulles se décale en fonction de la densité de bulle. Il est ainsi montré qu’il existe une densité de bulle optimale pour l’émission de la composante sous-harmonique. Ensuite, une stratégie de contrôle est développée, basée sur une boucle de rétroaction régulant la signature acoustique d’un régime donné de cavitation. L’utilisation de la stratégie d’asservissement permet de discriminer les régimes de cavitation stable et inertielle au cours du temps, mais aussi de garantir une activité de cavitation plus stable temporellement, plus reproductible, et ce pour des énergies acoustiques moyennes délivrées inférieures. Enfin, le processus de contrôle est utilisé expérimentalement pour des applications in-vitro de sonoporation cellulaire. Tout d’abord, une étude de sonoporation en cavitation inertielle régulée met en évidence l’amélioration de la reproductibilité des taux de sonoporation obtenus, et la possibilité de s’affranchir de l’utilisation d’agents de contraste comme agents de nucléation. Ensuite, une étude en cavitation stable régulée met en évidence la possibilité de sonoporer des cellules en limitant les activités de cavitation inertielle, et donc potentiellement en limitant la lyse cellulaire / In the aim of limiting the destructive behavior of collapsing cavitation bubbles, an exclusively stable cavitation state is targeted for sensitive therapeutics applications like blood-brain barrier opening. Ensuring a stable cavitation regime is complex because of (i) the coexistence of stably oscillating bubbles and collapsing bubbles in the same bubble cloud, and (ii) the stochastic behavior of the phenomenon during time. Therefore, it is necessary to control spatially and temporally the cavitation activity, by discriminating the stable from the inertial regime. Firstly, the theoretical study of the dynamics of a monodisperse and homogeneous cloud shows a modification of the stable cavitation threshold as a function of the bubble density: the subharmonics emission threshold is lowered and the resonance frequency is shifted. The study leads also to the expression of a particular microbubbles density leading to optimized subharmonics emission. Secondly, a real-time control strategy based on a feedback loop process on subharmonics emission is designed. The use of this strategy allows discriminating the two cavitation states during time, and ensures a better reproducibility, time-stability and an acoustic energy gain. The control device is used for cells sonoporation in-vitro. In a first study, the sonoporation by inertial cavitation control is performed in a stationary ultrasonic field configuration. This leads to high sonoporation efficiency coupled to the possibility of counterbalancing the use of supplementary nuclei (encapsulated microbubbles). In a second one, the stable cavitation control applied in a focused ultrasound configuration field pinpoints the possibility of sonoporating cells without inertial cavitation, and then to limit cell lysis
42

Étude expérimentale des écoulements multiphasiques dans une couche limite laminaire décollée. / Experimental study of multiphase flows within a separated laminar boundary layer.

Croci, Kilian 06 December 2018 (has links)
La cavitation hydrodynamique, et plus particulièrement la cavitation à poche attachée, peut apparaitre et se développer dans des écoulements turbulents complexes à l’intérieur de décollements de la couche limite laminaire. Ce phénomène s’avère être également sensible aux autres gaz présents dans l’écoulement comme l’air. Pour mieux comprendre l’attachement de poches de cavitation dans des décollements laminaires et l’influence de l’air sur celles-ci, nous proposons d’étudier des écoulements laminaires décollés d’huiles silicones visqueuses, contenant une grande quantité d’air, autour d’une géométrie Venturi lisse. Dans notre étude nous observons l’apparition de plusieurs types de poches, d’air ou de vapeur, qui peuvent s’attacher dans différents décollements de l’écoulement laminaire. Le dégazage joue alors un rôle important à hautes pressions, générant des poches d’air attachées présentant des dynamiques particulièrement intéressantes.À très basses pressions, des poches de cavitations peuvent s’attacher provoquantselon la stabilité de l’écoulement une transition à un régime transitionnel laminaire/turbulent dans leurs sillage. Cette même transition peut également apparaitre de façon intermittente à plus hautes pressions dans le sillage d’une bulle d’air recirculante, caractéristique du dégazage dans les écoulement laminaires décollés. Le régime transitionnel laminaire/turbulent, beaucoup moins sensible au dégazage, est caractérisé par de la cavitation de tourbillons, générés à hautes fréquences, dans le sillage d’un bulbe de décollement laminaire “court” le long de la pente du Venturi. Le bulbe se développe jusqu’à transitionner brutalement en bulbe “long” pour une taille de poche assez élevée, on peut associer ce phénomène à la supercavitation. / Hydrodynamic cavitation, more specifically attached cavitation, can emerge et develop in complex turbulent flows within laminar boundary layer separations. This phenomenon might be extremely sensitive to the gaz content in the flow. For an easier understanding of the attachment of cavities into laminar separated flows within the influence of air content, we propose to focus our study on viscous silicon oil laminar separated flows, presenting high gas content, within a smooth Venturi geometry. In this study, the inception of several types of attached cavities, filled with air or oil vapor, can be observed into different laminar flow separations. For high pressures, the degassing phenomenon is dominant in the flow, generating attached cavities filled with air presenting interesting dynamics. For low pressures, attach vapor cavities can emerge inducing, if the flow is unstable, the transition to laminar/turbulent transitioning regime in their wake. This transition can also occurs intermittently at higher pressures in the wake of a recirculating air bubble, characteristic to degassing into laminar separated flows. The laminar/turbulent transitioning regime, less sensitive to degassing, is characterized by vortex cavitation, occurring at high frequencies, at the rear of a “short” laminar separation bubble along the divergent Venturi slope. The “short” laminar separation bubble grows until transitioning to a “long” bubble within an large attached cavity. This transition can be associate to thesupercavitation phenomenon.
43

Rheological Implications of Tension in Liquids

Kottke, Peter Arthur 07 July 2004 (has links)
This research investigates effects of tensile stresses in liquids. Areas of application include bearing lubrication and polymer processing, in which liquids may be subjected to hydrostatic tension or large shear stresses. A primary thrust of this research is the development of a criterion for liquid failure, or cavitation, based upon the general state of stress in the liquid. A variable pressure, rotating inner cylinder, Couette viscometer has been designed and used to test a hypothesized cavitation criterion. The criterion, that cavitation will occur when a principal normal stress in a liquid becomes more tensile than some critical stress, is supported by the results of experiments with the viscometer for a Newtonian liquid. Based upon experimental observation of cavitation, a model for cavitation inception from crevice stabilized gas nuclei, and gaseous, as opposed to vaporous, cavitation is hypothesized. The cavitation inception model is investigated through numerical simulation, primarily using the boundary element method. Only Newtonian liquids are modeled, and, for simulation purposes, the model is reduced to two dimensions and the limit of negligible inertia is considered. The model includes contact line dynamics. Mass transport of dissolved gas through the liquid and in or out of the gas nucleus is considered. The numerical simulations provide important information about the probable nature of cavitation nucleation sites as well as conditions for cavitation inception. The cavitation criterion predicts cavitation in simple shear, which has implications for rheological measurements. It can cause apparent shear thinning and thixotropy. Additionally, there is evidence suggesting a possible link between shear cavitation and extrusion defects such as sharkskin. A variable pressure capillary tube viscometer was designed and constructed to investigate a hypothesized relationship between shear cavitation and extrusion defects. Results indicate that despite the occasional coincidence of occurrence of cavitation and sharkskin defects, cavitation cannot explain the onset of extrusion defects. If nuclei are removed, then liquids can withstand a negative hydrostatic pressure. A falling body viscometer has been constructed and used to investigate the effect of negative pressures on viscosity. It is found that current pressure viscosity models can be accurately extrapolated to experimentally achievable negative pressures.
44

Physique et biologie moléculaire de la vulnérabilité du xylème à la cavitation / Physics and molecular biology of xylem vulnerability to cavitation

Tixier, Aude 16 December 2013 (has links)
La vulnérabilité du xylème à la cavitation est un caractère déterminant pour la tolérance des arbres à une sécheresse extrême. La connaissance des bases moléculaires de caractère serait utile pour prévoir le comportement des populations naturelles et pour orienter les choix de culture dans un contexte de changement climatique. Ce travail de thèse porte sur les bases physiques et génétiques de la vulnérabilité à la cavitation en ciblant les ponctuations car il est désormais bien admis que les ponctuations des vaisseaux du xylème sont des structures clés de ce caractère. Nous proposons un modèle mécanique de comportement des ponctuations lors de la cavitation. Il démontre comment la géométrie des ponctuations détermine leurs propriétés mécaniques et permet d’expliquer la variabilité interspécifique de la vulnérabilité à la cavitation. Pour appréhender les bases génétiques, deux approches ont été développées. D’une part, nous avons construit des lignées transgéniques de peupliers modifiées pour le métabolisme des pectines. D’autre part, nous avons montré qu’Arabidopsis thaliana est une plante modèle qui permet de prospecter les bases génétiques de la vulnérabilité à la cavitation. L’étude des lignées transgéniques de peuplier et d’un mutant d’Arabidopsis thaliana modifiés pour l’expression de polygalacturonases met en évidence l’implication de ces enzymes et plus généralement des pectines dans la vulnérabilité à la cavitation. L’ensemble de nos résultats nous amène à proposer un rôle des pectines au niveau de l’anneau de la membrane des ponctuations, dans la vulnérabilité à la cavitation. / Vulnerability to cavitation is an important feature for drought tolerance of trees. Understanding of the molecular basis of vulnerability to cavitation would be useful to predict the behavior of natural populations in the context of changing climate. This work focuses on the physical and genetic basis of vulnerability to cavitation and targets pits because they represent main candidates for the spread of embolism in wood. We propose a model of the mechanical behavior of pits while cavitation occurs. The model shows how the pits geometry influences their mechanical properties and allows explaining interspecific variability of vulnerability to cavitation. On one hand, we constructed transgenic poplars modified for pectin metabolism. On the other hand, we showed that Arabidopsis thaliana is a model plant that can be used for the study of the molecular basis of vulnerability to cavitation. Studies of poplars’ transgenic lines and Arabidopsis thaliana mutant modified for a polygalacturonase highlights the involvement of pectins in vulnerability to cavitation. Our results suggest that pectins that are located on the annulus of the pit membrane have a role in vulnerability to cavitation.
45

Développement d’une méthode numérique compressible pour la simulation de la cavitation en géométrie complexe. / On the cavitation modeling using compressible Navier-Stokes equations and a high-resolution finite volume scheme

Bergerat, Lionel 17 December 2012 (has links)
La cavitation est un phénomène de changement de phase dans les zones de basses pressions des machines hydrauliques. Ses conséquences sont souvent néfastes : pertes de performances, génération de bruit et de vibrations, abrasion des matériaux... Ces effets deviennent une préoccupation importante dans la conception des machines hydrauliques. Ce travail a pour objectif principal de développer un modèle de simulation numérique pour la simulation de la cavitation à haut ordre de précision, pour des écoulements compressibles visqueux, et pour des géométries complexes. Le modèle adopté pour la modélisation de la cavitation est le modèle de mélange homogène. Cette formulation ne dépend d'aucun paramètre empirique et peut être aisément étendu à du multi-espèce. Nous utilisons un code de volumes finis, dont le haut ordre de reconstruction est assuré par la méthode des moindres carrés mobiles. / Cavitation is a phase change phenomenon, wich occurs in low pressure areas in hydraulic systems. Its consequences are often harmful and undesired : it causes loss of efficiency, noise and vibration generation, and structural abrasion... These effects become a major preoccupation in the conception of hydraulic systems. The main objective of this work is to develop a numerical tool for the numerical modelisation of cavitation at high orders of accuracy, for compressible and viscous flows, in complex geometries. The model used for the modelisation of the cavitation is the homogeneous mixture model, wich formulation is independent of empirical parameters, and is easily extendable for multi-spieces flows. We use a finite volume developped in the DynFluid laboratory, in wich the high accuracy order of reconstruction is obtained using the Moving Least Square approximation.
46

Dynamika kavitujícího proudění za clonou / Dynamics of cavitating flow behind the orifice

Kubina, Dávid January 2018 (has links)
Cavitating flow through five perforated plates with different number of holes with preserved constant flow cross-section area in sum were experimentally examined. Dynamic characteristics such as dependence of pressure amplitudes and dominant frequencies on cavitation number in all regimes of cavitating flow: incipient cavitation, partial cavitation, fully developed cavitation and supercavitation are obtained. For determination of dominant frequencies several pressure transducers in two regimes of measurement were used. Results were validated with frequency spectra obtained from picture analysis based on high-speed camera records.
47

Zpracování naměřených signálů z kavitačních experimentů / Analysis of measured signals from cavitation experiments

Asszonyi, Ondřej January 2020 (has links)
This thesis focuses on problem with detection of cavitation in hydraulic systems and devices. Thesis works with data from cavitation tunnel experiment, where cavitation appeared on blade. It founds out if time records and their frequency spectrum is dependent on operating conditions. Data are examined by various statistic methods. All of that is then used in method called neural network.
48

Experimental Simulation of Cavitation Erosion

Hedlund, Nina January 2014 (has links)
No description available.
49

Role of Cavitation during Bulk ultrasound Ablation: Ex vivo and In vivo Studies

Karunakaran, Chandrapriya 16 October 2012 (has links)
No description available.
50

Fundamental Studies on Cavitation Dynamics in Superfluid Helium, Critical Helium, and Solid Helium

Alghamdi, Tariq 08 1900 (has links)
We focus on studying laser-induced cavitation under widely different physical conditions, from superheated jets to superfluid liquid helium. We use ultra high-speed video imaging to track cavitation bubble dynamics at frame-rates of up to 7 million frames-per-second. Cavitation is induced by focusing a 532 nm pulsed Nd-YAG laser at a spot with a minimum spot size of 150 μm and pulse duration of six ns, which forms high-pressure plasma, leading to a rapidly expanding bubble/void, which subsequently collapses. We mainly study two configurations: (1) laser-induced cavitation in liquid helium inside an optical cryostat and (2) laser-induced cavitation in HCP solid helium. Moreover, we report preliminary results of two promising studies: (3) laser-induced cavitation inside a highly turbulent flow within a square channel and (4) laser-induced break-up inside a cylindrical liquid jet, leading to its atomization. (1) Inside the liquid helium-4, we reach widely different thermodynamic conditions when adjusting the temperature between 1.4 to 5.1 degrees Kelvin. Below the lambda point at T = 2.17 K, the liquid is superfluid, with viscosity appr zero, while above this temperature, regular liquid helium approaches the critical point at ≃ 5.1 K. This greatly changes the cavitation dynamics with different amounts of vapor appearing during cavity growth and collapse, and revealed four regimes of cavitation bubble behavior. We also measure shock velocities and analyze their characteristics. (2) At pressures of roughly 25 atmospheres, superfluid helium (He-II) solidifies. With wavy time-evolving oscillations on its surface when disturbed, the interface between the solid and the superfluid exhibits fascinating behavior with wavy time-evolving oscillations on its surface when disturbed. The interface between liquid and solid can consequently behave similarly to a free surface. Here, we experimentally investigate laser-induced interfacial dynamics at temperatures between 1.2 K and 2 K and at pressures ranging from the melting pressure of approximately 25 atm to a maximum of 39 atm, which covers both the HCP and BCC structure of the solid, using ultra-high-speed imaging at frame rates up to 7 million frames per second. (3) The cavitation inside the turbulent flow; this study aims to investigate the mutual effect of the rapid straining outside the bubble on the coherent vortices within the liquid and the feedback from the modified turbulence on the shape of the vapor cavity, and to include time-resolved particle image velocimetry. (4) The cavitation inside a liquid jet helps break it up into fine spray, which is of interest for injectors in combustion engines.

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