The work description is to create a system of measures to prevent the spread and the consequent attenuation of sound in air handling systems serving the cleanrooms. The thesis presents a solution to noise attenuation in the investigated area, and in HVAC duct, which uses a commercially available material in the form of sound insulation hoses. In the systém solution is part of the work focuses on the optimal design of terminal elements to distribute air in a clean room. Processing methods utilize theoretical and experimental approach. The experiment comprises a unique analysis of the sound insulation properties of selected products under specific conditions. The data obtained are analyzed and incorporated into the framework of this work created program module for determining the attenuation and noise propagation in an enclosed space. Math and physical dependence are programmed into their own DLL by programming language DELPHI.