Simplified methods of analysis described in codes and specifications for seismically isolated structures are always used either directly in special cases or for checking the results of nonlinear response history analysis (RHA). Important predictions for seismically isolated structures by simplified methods are the maximum displacements and base shears of the isolation system. In this study, the maximum isolator displacements and base shears determined by nonlinear RHA are compared with those determined by the equivalent lateral force (ELF) procedure in order to assess the accuracy of the simplified method in the case of bi-directional excitations with near-field characteristics. However, although there are currently many methods for ground motion selection and scaling, little guidance is available to classify which method is more appropriate than the others in any applications. Features of this study are that the ground motions used in analysis are selected and scaled using contemporary concepts and that the ground excitation is considered biv directional. The variations in response of isolated structures due to application of ground motions uni-directionally and bi-directionally are also studied by employing a scaling procedure that is appropriate for the bi-directional analysis. The proposed new scaling methodology is an amplitude scaling method that is capable of preserving the horizontal orthogonal components and it is developed especially for dynamic analysis of isolated structures. Analyses are conducted for two different symmetric reinforced concrete isolated structure for two different soil conditions in structural analysis program SAP2000. Effect of asymmetry in superstructure on isolator displacement is also investigated with further analyses considering 5% mass eccentricity at each floor level. Furthermore, once the significance of the orthogonal horizontal component on the response of isolation system is shown, the biaxial interaction of hysteretic behavior of lead rubber bearings is implemented in OpenSees by developing a subroutine which was not readily available.

Cylindrically conformal microstrip antennas are investigated. Two different structures, namely proximity coupled and E-shaped microstrip antennas are analyzed and information about the design parameters is obtained by means of parametric study. With these structures, cylindrical arrays, having omnidirectional radiation in the circumferential plane of the cylinder, are designed. Proximity coupled cylindrical arrays operate in the 2.3-2.4 GHz aeronautical telemetry band with approximately 4% bandwidth. On the other hand, more than 30% bandwidth is obtained by E-Shaped cylindrical array antenna structure, which also includes the commercial telemetry band. In order to verify the simulation method, a fabricated antenna in literature is simulated and acceptable agreement with simulation and fabrication results obtained.

Previous research from environmental psychology shows that human well-being suffers in windowless environments in many ways and a window view of nature is psychologically and physiologically beneficial to humans. Current window substitutes, still images and video, lack three dimensional properties necessary for a realistic viewing experience – primarily motion parallax. We present a new system using a head-coupled display and image-based rendering to simulate a photorealistic artificial window view of nature with motion parallax. Evaluation data obtained from human subjects suggest that the system prototype is a better window substitute than a static image and has significantly more positive effects on observers’ moods. The test subjects judged the system prototype as a good simulation of, and acceptable replacement for, a real window, and accorded it much higher ratings for realism and preference than a static image.

The work we present in this thesis is a series of studies of how heterogeneities in coupling affect the synchronization of coupled neural oscillators. We begin by examining how heterogeneity in coupling strength affects the equilibrium phase difference of a pair of coupled, spiking neurons when compared to the case of identical coupling. This study is performed using pairs of Hodgkin-Huxley and Wang-Buzsaki neurons. We find that heterogeneity in coupling strength breaks the symmetry of the bifurcation diagrams of equilibrium phase difference versus the synaptic rate constant for weakly coupled pairs of neurons. We observe important qualitative changes such as the loss of the ubiquitous in-phase and anti-phase solutions found when the coupling is identical and regions of parameter space where no phase locked solution exists. Another type of heterogeneity can be found by having different types of coupling between oscillators. Synaptic coupling between neurons can either be exciting or inhibiting. We examine the synchronization dynamics when a pair of neurons is coupled with one excitatory and one inhibitory synapse. We also use coupled pairs of Hodgkin-Huxley neurons and Wang-Buzsaki neurons for this work. We then explore the existance of 1:n coupled states for a coupled pair of theta neurons. We do this in order to reproduce an observed effect called quantal slowing. Quantal slowing is the phenomena where jumping between different $1:n$ coupled states is observed instead of gradual changes in period as a parameter in the system is varied. All of these topics fall under the general heading of coupled, non-linear oscillators and specifically weakly coupled, neural oscillators. The audience for this thesis is most likely going to be a mixed crowd as the research reported herein is interdisciplinary. Choosing the content for the introduction proved far more challenging than expected. It might be impossible to write a maximally useful introductory portion of a thesis when it could be read by a physicist, mathematician, engineer or biologist. Undoubtedly readers will find some portion of this introduction elementary. At the risk of boring some or all of my readers we decided it was best to proceed so that enough of the mathematical (biological) background is explained in the introduction so that a biologist (mathematician) is able to appreciate the motivations for the research and the results presented. We begin with a introduction in nonlinear dynamics explaining the mathematical tools we use to characterize the excitability of individual neurons, as well as oscillations and synchrony in neural networks. The next part of the introductory material is an overview of the biology of neurons. We then describe the neuron models used in this work and finally describe the techniques we employ to study coupled neurons.

Industrial and military vehicles, including trucks, tanks and others, employ cooling systems that address passenger cooling and auxiliary cooling loads ranging from a few Watts to 50 kW or more. Such systems are typically powered using vapor-compression cooling systems that either directly supply cold air to the various locations, or cool an intermediate single-phase coolant closed loop, which in turn serves as the coolant for the passenger cabins and auxiliary loads such as electronics modules. Efforts are underway to enhance the performance of such systems, and also to develop more light weight and compact systems that would remove high heat fluxes. The distributed cooling configuration offers the advantage of a smaller refrigerant system package. The heat transfer between the intermediate fluid and air or with the auxiliary heat loads can be fine tuned through the control of flow rates and component sizes and controls to maintain tight tolerances on the cooling performance. Because of the additional loop involved in such a configuration, there is a temperature penalty between the refrigerant and the ultimate heat sink or source, but in some configurations, this may be counteracted through judicious design of the phase change-to-liquid coupled heat exchangers. Such heat exchangers are inherently smaller due to the high heat transfer coefficients in phase change and single-phase liquid flow compared to air flow. The additional loop also requires a pump to circulate the fluid, which adds pumping power requirements. However, a direct refrigerant-to-heat load coupling system might in fact be suboptimal if the heat loads are distributed across large distances. This is because of the significantly higher pressure drops (and saturation temperature drops) incurred in transporting vapor or two-phase fluids through refrigerant lines across long plumbing elements. An optimal system can be developed for any candidate application by assessing the tradeoffs in cooling capacity, heat exchanger sizes and configurations, and compression, pumping and fan power. In this study, a versatile simulation platform for a wide variety of direct and indirectly coupled cooling systems was developed to enable comparison of different component geometries and system configurations based on operating requirements and applicable design constraints. Components are modeled at increasing levels of complexity ranging from specified closest approach temperatures for key components to models based on detailed heat transfer and pressure drop models. These components of varying complexity can be incorporated into the system model as desired and trade-off analyses on system configurations performed. Employing this platform as a screening, comparison, and optimization tool, a number of conventional vapor-compression and distributed cooling systems were analyzed to determine the efficacy of the distributed cooling scheme in mobile cooling applications. Four systems serving approximately a 6 kW cooling duty, two with air-coupled evaporators and two with liquid-coupled evaporators, were analyzed for ambient conditions of 37.78°C and 40% relative humidity. Though the condensers and evaporators are smaller in liquid-coupled systems, the total mass of the heat exchangers in the liquid-coupled systems is larger due to the additional air-to-liquid heat exchangers that the configuration requires. Additionally, for the cooling applications considered, the additional compressor power necessitated by the liquid-coupled configuration and the additional power consumed by the liquid-loop pumps result in the coefficient of performance being lower for liquid-coupled systems than for air-coupled systems. However, the use of liquid-coupling in a system does meet the primary goal of decreasing the system refrigerant inventory by enabling the use of smaller condensers and evaporators and by eliminating long refrigerant carrying hoses.

Tailoring the radiative properties of periodic micro/nanostructures can be used as an efficient way to create devices which have applications in energy harvesting, bioengineering and optical sensing. These structures are analyzed by a rigorous solution of the electromagnetic wave phenomena at the interfaces. The thesis explores the application of rigorous coupled-wave analysis (RCWA) method to study the optical responses of microstructure arrays. First section of the thesis elucidates the various mechanisms which are responsible for causing enhanced light absorption in inclined parallel plate grating arrays. Illustrative evidences of surface plasmon and magnetic resonances are provided by one and two-dimensional plots prepared by RCWA. Analytical agreement with visual data is obtained through use of LC circuit models. Finally, the effects of different geometric parameters on the resonance conditions are investigated. The second part of the thesis deals with application of RCWA to study the effect of light scattering on inclined silver nanorod (AgNR) arrays grown on compact disc (CD) gratings. Depending on the manner in which AgNRs are oriented with respect to CD gratings, they exhibit different optical behavior to incoming light. Effects of both incident light polarization and AgNR orientation with respect to the grating have been studied through the use of RCWA and effective medium theory. Calculated results are compared with experimental values and good agreements are observed for total reflection as well as trends of individual diffraction orders.

<p>Questions have been raised about the genomic complexity of the human genome, since it was reported that it only consisted of 32,000 genes. Alternative splicing is considered the explanation of the enormous difference between the number of genes and the number of proteins. Aligning expressed sequence tags (ESTs) to the genomic sequence has become a popular approach for gene prediction, revealing alternative splice variants. The aim in this thesis is to identify and analyse splice variants of the adhesion family of G protein-coupled receptors using EST data. 75% of the genes in the data set of 33 sequences were found to have a total of 51 splice variants. About half of the variants were considered functional.</p>

Considering the late in-vessel phase of an unlikely core melt down scenario in a light water reactor (LWR) with the formation of a corium pool in the lower head of the re-actor pressure vessel (RPV) the possible failure modes of the RPV and the time to failure have to be investigated to assess the possible loadings on the containment. In this work, an integral model was developed to describe the processes in the lower plenum of the RPV. Two principal model domains have to be distinguished: The temperature field within the melt and RPV is calculated with a thermodynamic model, while a mechanical model is used for the structural analysis of the vessel wall. In the introducing chapters a description is given of the considered accident scenario and the relevant analytical, experimental, and numerical investigations are discussed which were performed worldwide during the last three decades. Following, the occur-ring physical phenomena are analysed and the scaling differences are evaluated between the FOREVER-experiments and a prototypical scenario. The thermodynamic and the mechanical model can be coupled recursively to take into account the mutual influence. This approach not only allows to consider the tem-perature dependence of the material parameters and the thermally induced stress in the mechanical model, it also takes into account the response of the temperature field itself upon the changing vessel geometry. New approaches are applied in this work for the simulation of creep and damage. Using a creep data base, the application of single creep laws could be avoided which is especially advantageous if large temperature, stress, and strain ranges have to be covered. Based on experimental investigations, the creep data base has been de-veloped for an RPV-steel and has been validated against creep tests with different scalings and geometries. It can be stated, that the coupled model is able to exactly describe and predict the vessel deformation in the scaled integral FOREVER-tests. There are uncertainties concerning the time to failure which are related to inexactly known material parame-ters and boundary conditions. The main results of this work can be summarised as follows: Due to the thermody-namic behaviour of the large melt pool with internal heat sources, the upper third of the lower RPV head is exposed to the highest thermo-mechanical loads. This region is called hot focus. Contrary to that, the pole part of the lower head has a higher strength and therefore relocates almost vertically downwards under the combined thermal, weight and internal pressure load of the RPV. On the one hand, it will be possible by external flooding to retain the corium within the RPV even at increased pressures and even in reactors with high power (as e.g. KONVOI). On the other hand, there is no chance for melt retention in the considered scenario if neither internal nor external flooding of the RPV can be achieved. Two patents have been derived from the gained insights. Both are related to pas-sively working devices for accident mitigation: The first one is a support of the RPV lower head pole part. It reduces the maximum mechanical load in the highly stressed area of the hot focus. In this way, it can prevent failure or at least extend the time to failure of the vessel. The second device implements a passive accident mitigation measure by making use of the downward movement of the lower head. Through this, a valve or a flap can be opened to flood the reactor pit with water from a storage res-ervoir located at a higher position in the reactor building. With regard to future plant designs it can be stated - differing from former presump-tions - that an In-Vessel-Retention (IVR) of a molten core is possible within the reac-tor pressure vessel even for reactors with higher power.

Es wurde ein Modell zur realistischen Beschreibung der Kühlmittelvermischung innerhalb des Reaktordruckbehälters von Druckwasserreaktoren in den gekoppelten Programmkomplex DYN3D/ATHLET implementiert. Diese Modell basiert auf dem Prinzip der linearen Superposition Dirac-Impuls-ähnlicher Störungen und kann für die Modellierung der Vermischung von Kühlmittel unterschiedlicher Temperatur und/oder unterschiedlicher Borsäurekonzentration eingesetzt werden. Der um das Vermischungsmodell erweiterte Programmkomplex DYN3D/ATHLET wurde für Analyse von Borverdünnungsstörfällen und Frischdampflecks angewandt. Für den Fall "Start der ersten Hauptkühlmittelpumpe bei Vorhandensein eines minderborierten Pfropfens im kalten Strang" zeigten die Ergebnisse der durchgeführten Parameterstudie, dass es selbst bei Annahme des maximal möglichen Pfropfenvolumens nicht zu einer Schädigung des Brennstoffes kommt. Mit den Analysen zu einem generischen Frischdampfleckszenario wurde die Anwendbarkeit des Programmkomplexes DYN3D/ATHLET auf die zweite Störfallklasse, in der die Kühlmittelvermischung eine wichtige Rollen spielt, demonstriert. Im Rahmen der Arbeiten zum Projekt wurde außerdem gezeigt, dass der Einfluss der turbulenten Schwankungen des Geschwindigkeitsfeldes innerhalb des Reaktordruckbehälters auf neutronenkinetische Parameter im Nominalbetrieb und unter Störfallbedingungen nicht zu vernachlässigen ist. A model for the realistic description of the coolant mixing inside the pressure vessel of pressurized water reactors was implemented into the coupled code complex DYN3D/ATHLET. This model is based on the linear superposition Dirac-pulse-like perturbations. The model can be applied to the mixing of coolant of different temperature and/or boron concentration. The coupled code complex DYN3D/ATHLET with the newly implemented model was applied to the analysis of boron dilution and steam line break accidents. The results of a parameter study for the case "Start-up of the first main coolant pump with a slug of lower borated water in the cold leg" have shown, that even under the conditions of the maximum slug volume there is no fuel damage. The applicability to the second class of accidents, where the coolant mixing has to be considered, was demonstrated by the analysis of a generic main steam line break scenario. Further it was shown, that the influence of turbulent fluctuations of the velocity inside the reactor pressure vessel during nominal and accident conditions on neutron-kinetic parameters cannot be neglected.

Das Vorhaben bestand in der Validierung des gekoppelten neutronenkinetisch-thermohydraulischen Programmkomplexes ATHLET/DYN3D für Siedewasserreaktoren durch Teilnahme an dem OECD/NRC Benchmark zum Turbinenschnellschluss. Das von der OECD und der amerikanischen NRC definierte Benchmark basiert auf einem Experiment mit Schließens des Turbinenschnellschlussventils, das 1977 im Rahmen einer Serie von 3 Experimenten im Kernkraftwerk Peach Bottom 2 durchgeführt wurde. Im Experiment erzeugte das Schließen des Ventils eine Druckwelle, die sich unter Abschwächung bis in den Reaktorkern ausbreitete. Die durch den Druckanstieg bewirkte Kondensation von Dampf im Reaktorkern führte zu einem positiven Reaktivitätseintrag. Der folgende Anstieg der Reaktorleistung wurde durch die Rückkopplung und das Einfahren der Regelstäbe begrenzt. Im Rahmen des Benchmarks konnten die Rechenprogramme durch Vergleiche mit den Messergebnissen und den Ergebnissen der anderen Teilnehmer an dem Benchmark validiert werden. Das Benchmark wurde in 3 Phasen oder Exercises eingeteilt. Die Phase I diente der Überprüfung des thermohydraulischen Modells für das System bei vorgegebener Leistungsfreisetzung im Kern. In der Phase II wurden 3-dimensionale Berechnungen des Reaktorkerns für vorgegebene thermohydraulische Randbedingungen durchgeführt. Die gekoppelten Rechnungen für das ausgewählte Experiment und für 4 extreme Szenarien erfolgten in der Phase III. Im Rahmen des Projekts nahm FZR an Phase II und Phase III des Benchmarks teil. Die Rechnungen für Phase II erfolgten mit dem Kernmodell DYN3D unter Berücksichtigung der Heterogenitätsfaktoren und mit 764 thermohydraulischen Kanälen (1 Kanal/Brennelement). Der ATHLET-Eingabedatensatz für die Reaktoranlage wurde von der Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) übernommen und für die Rechnungen zu Phase III, die mit der parallelen Kopplung von ATHLET mit DYN3D erfolgten, geringfügig modifiziert. Für räumlich gemittelte Parameter wurde eine gute Übereinstimmung mit den Messergebnissen und den Resultaten anderer Codes erzielt. Der Einfluss der Modellunterschiede wurde mit Hilfe von Variantenrechnungen zu Phase II untersucht. So können Unterschiede in der Leistungs- und Voidverteilung in einzelnen Brennelementen auf die unterschiedliche neutronenkinetische und thermohydraulische Modellierung des Reaktorkerns zurückgeführt werden. Vergleiche zwischen ATHLET/DYN3D (parallele Kopplung) und ATHLET/QUABOX-CUBBOX (interne Kopplung) zeigen für räumlich gemittelte Parameter nur geringe Unterschiede. Abweichungen in den lokalen Parametern können im wesentlichen mit der unterschiedlichen Modellierung des Reaktorkerns erklärt werden (geringere Anzahl von modellierten Kühlkanälen, keine Berücksichtigung der Heterogenitätsfaktoren und ein anderes Siedemodell in der Rechnung mit ATHLET/QUABOX-CUBBOX). Die Rechnungen für die extremen Szenarien von Phase III zeigen die Anwendbarkeit des gekoppelten Programms ATHLET/DYN3D für die Bedingungen bei Störfällen, die weit über das Experiment hinausgehen.