Exposure to multiple forms of victimization has been shown to have increasingly negative outcomes, but their unique trajectory-setting effects have been largely unexplored. Using a life course approach, this paper examines the trajectory-setting effects of childhood polyvictimization into early adulthood. I use a nationwide sample including 3,652 respondents after cleaning and preparation. Seemingly unrelated regressions were used to predict depression and criminal behavior in childhood and adulthood. Results suggest childhood polyvictimization sets children on a negative trajectory which grows increasingly worse through the life course. Researchers and interventions should take these trajectory-setting effects into account when attempting to aid polyvictims.