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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Modelování vazby variant insulinu k insulinovému receptoru díky průlomům ve strukturní biologii / Modelling Binding of Insulin Variants toward Insulin Receptor Based on Recent Structural Breakthroughs

Černeková, Michaela January 2019 (has links)
Insulin receptor is a multi-domain signalling protein acting as a dimer. It comprises an extracellular ectodomain, a transmembrane domain and intracellular tyrosine kinase domain. Upon insulin binding, conformational changes in insulin as well as in insulin receptor occur and trigger the signaling cascade via the kinase domain. Abnormalities in insulin and insulin receptor function cause diabetes mellitus, a widespread disorder which can be consequence of genetic factors as well as lifestyle and is manifested by increased level of blood glucose. A common treatment of diabetes mellitus is via insulin analogues with different molecular properties. Insulin/insulin receptor interactions in the binding pocket are divided into two groups, so-called "site1" and "site2". The molecular details of the interactions in site1 are well known, while site2 residues are still not completely elucidated. It is important to shed light on the binding properties of insulin and insulin receptor, especially site2 interactions, because it could contribute to improved design of new insulin analogues. In this work, we used the very recent breakthroughs in the structural biology of insulin receptor to study the interactions by computational chemistry methods. It was thus possible to assess the noncovalent interactions and...
2

Informovanost žáků 8. a 9. ročníků základních škol o chronických neinfekčních nemocech

KOLMANOVÁ, Aneta January 2016 (has links)
The aim of this diploma thesis was to assess the current knowledge of the pupils of 8th and 9th grades of primary schools about selected chronical non-infectious diseases (known as civilisation diseases). The pupils of rural and urban types of primary schools have taken part in the questionnaire survey. The theoretical part is focused on the characteristics of selected diseases, their causes and prevention. In the practical part, the results of the survey are processed and evaluated.

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