This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source Glossina resource (G-ESTMAP) was developed that provides interactive features and browsing of functional genomics data for researchers working in the field of Trypanosomiasis on the African continent.

近年來，各國政府積極推動文化創意產業，藉以帶動其他產業促進整體經濟發展，提升生活環境；其中節慶不僅能為地方或城市提供正向發展，亦屬於一文化創意展演平台，使文化商品得以於消費者面前曝光。 本研究主張，守門機制對於節慶與文化創意產業具有重要影響，檢閱相關文獻後，本研究以「2014年簡單生活節」為個案，運用「守門機制理論」作為個案分析的研究架構。本研究之研究問題為「2014年簡單生活節如何發揮守門機制功能」，為回答研究問題，本研究採用個案研究法，藉由參與式觀察與深入訪談，瞭解簡單生活節團隊如何執行其守門機制角色，並探討其守門成果對於節慶本身與文創產業的影響，得以彌補守門機制以及節慶創新理論上的文獻缺口。 本研究發現在2014年簡單生活節的守門過程中，簡單生活節團隊在劃定邊界的過程除了會受到守門專業能耐影響外，亦被牽制於可篩選的內容，導致其守門過程是一反覆修正的過程。此外，除了文獻中提及的四種守門能耐外，本研究更發現在2014年簡單生活節中最重要的守門能耐為「策展能力」，策展能力讓簡單生活節團隊能協助品牌於節慶中呈現出更適切且驚喜的內容，並提升品牌能見度。最後，本研究建議，未來節慶策展團隊都應將「守門機制」之思維納入其策展規劃，並且重視策展能力的運用，藉此能了解自身的守門類型，提升節慶的策展內容，進而協助節慶本身與產業持續創新。 / The purpose of the study is to investigate the importance of gatekeeping process in cultural festivals and the cultural and creative industries. This study uses the gatekeeping theory which is commonly discussed in the area of communications in order to understand how the festival carries out gatekeeping function in its curation by using an example of the “2014 Urban Simple Life Festival”. The research question of the study is “how the 2014 Urban Simple Life Festival uses gatekeeping in the curation?”. The study adopts case study and uses participant observations and in-depth interviews as the research tools to investigate how the gatekeeping is used in the 2014 Urban Simple Life Festival curation. In addition, this research aims to explore how the gatekeeping outcomes influence festivals themselves and the innovations of the cultural and creative industries. This research finds out that the festival organizer’s gatekeeping abilities and the gatekeeping contents do affect the gatekeeping boundary. Furthermore, the gatekeeping process is a repeated correcting process. Apart from the four gatekeeping abilities in the existed literature, the study also discovers that the most important gatekeeping ability in festivals is the “curatorial ability”. With the curatorial ability, the festival organizer would be able to help and assist the participants to present their best work in the Festival as well as to enhance their brand visibility to the market. This study suggests that the festival organizer should take the “curatorial ability” into consideration during the curation process to enhance the innovation ability of the cultural and creative industries

This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source Glossina resource (G-ESTMAP) was developed that provides interactive features and browsing of functional genomics data for researchers working in the field of Trypanosomiasis on the African continent.

The project-based research questions how professionals working in the built environment can engage a broader range of 'others' (students, client, users) in ways of seeing and acting in a meaningful way. It challenges the role of the expert in architecture and urban design and in particular their use of the masterplan, which is often an oversimplified reductive response, laden with generalisations and the ill-considered overlay of inappropriate models. Design methods are designed to enable us to see afresh and respond accordingly. These are demonstrated in three suites of projects that include urban installations such as Five Walks for the Melbourne International Arts Festival, war memorials, lectures, photographs and teaching practice such as Taipei Operations, a student workshop, architectural exhibition, and book. The design research is situated within an expanded field of cross-disciplinary practice that includes art, landscape architecture, urban design, architecture and geography. Tools are developed to enable us to understand the city at many spatial and temporal scales; observations made at a micro scale reveal systems at a macro scale - a bottom-up approach. The application of the methods explored implies that

This thesis offers the first detailed study of publishing culture in the medieval eastern Islamic world by examining how two influential anthologists active in Central Asia mediated between authors and their audiences. It analyses the contents of al-Tha'ālibī's (d. 429/1037-8) Yatīmat al-dahr, a biographical anthology of Arabic poetry and prose concerned with the literature of the 4th/10th and the early 5th/11th centuries, comparing them with the material found in 'Awfī's (d. 640/1242 or before) Lubāb al-albāb, a biographical anthology of Persian poetry focused on verse produced between the late 3rd/9th and the early 7th/13th centuries. Yatīmat al-dahr and Lubāb al-albāb are approached as ventures which aimed to render the high culture of Arabic and Persian literature accessible to readers by presenting hitherto unpublished texts in a pedagogical fashion. The thesis contributes to a current wave of research that is concerned with the history of the book in the Islamic world, but it moves the focus of such scholarship onto literary texts and their manipulation. Its principal findings can be summarised as follows: Firstly, it revises the prevalent idea that literary culture was entirely dependent on patronage, by demonstrating how market demand influenced the kinds of writing produced in the different regions of the Arabic- and Persian-speaking worlds. Patronage emerges as a force that was intertwined with the book trade, which had already begun to define conceptions of authorship. Secondly, it shows that anthologies are more than collections of exemplary texts, by uncovering how al-Tha'ālibī and 'Awfī pursue the study of society, literary history and literary theory. The anthologists did not simply reproduce extracts, but edited them in accordance with their broader intellectual projects. Lastly, it reconstructs the cosmopolitan literary culture which existed in Khurasan and Transoxiana between the 4th/10th and 7th/13th centuries, showing that many authors worked in bilingual Arabic-Persian environments, moved between Arabic and Persian spheres, and read books in both languages. The thesis is accompanied by an index of circa eight thousand poems catalogued by genre, and by an appendix which lists the material that the anthologists drew from their sources.

Submitted by LUCINEIA DA SILVA BATISTA (lucineia.bat@gmail.com) on 2018-06-21T14:19:20Z No. of bitstreams: 1 Faculdade de Filosofia e Ciências entrega final.pdf: 3104407 bytes, checksum: 3308c4b1b2655ae6a77c6839fa536d16 (MD5) / Approved for entry into archive by Satie Tagara (satie@marilia.unesp.br) on 2018-06-21T14:56:18Z (GMT) No. of bitstreams: 1 batista_ls_me_mar.pdf: 3104407 bytes, checksum: 3308c4b1b2655ae6a77c6839fa536d16 (MD5) / Made available in DSpace on 2018-06-21T14:56:18Z (GMT). No. of bitstreams: 1 batista_ls_me_mar.pdf: 3104407 bytes, checksum: 3308c4b1b2655ae6a77c6839fa536d16 (MD5) Previous issue date: 2018-05-23 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Este projeto tem como objeto de estudo e customização o software Acess to Memory (AtoM), sistema de descrição e representação de acervos arquivísticos aplicado ao setor de documentação de museu histórico. Pretende-se por meio desta aplicação estudar a adaptação e o uso do AtoM na produção documental e representação de objetos em instituições museológicas de acervos diversos e heterogêneos. O sistema AtoM, originário de convenio entre O Conselho Internacional de Arquivos (ICA) e o grupo Artefactual propicia a descrição de acervos memoriais e a conseqüente representação da memória em instituições arquivisticas, propiciando o acesso à informação desses acervos. Nesse projeto, busca-se contribuir com a Ciência da Informação (CI) e com a Museologia no que diz respeito às possibilidades de acesso, de compartilhamento e de interação dos sujeitos com a informação custodiada por essas instituições, pois as novas potencialidades do AtoM no contexto de museus permitem customizar a descrição padronizada dos objetos e a interoperabilidade entre sistemas. A iniciativa justifica-se por sua relevância social, pois softwares abertos, livres e customizáveis, como o AtoM, com potencialidades de tratamento horizontal da informação permitem uma espécie de conversação entre os indivíduos atuantes, tornando-os protagonistas de suas histórias. Assim, foi feita uma investigação interdisciplinar entre a CI e a Museologia e, posteriormente, uma compilação dos conceitos e temas elencados para a proposição de otimização do uso do sistema em ambiente museológico, tendo em vista as necessidades representativas dos acervos museológicos no Brasil, em que se dispõe somente de softwares proprietários de representação e catalogação. Será realizada também uma exploração participativa no ambiente digital multinível do AtoM com o intuito de entender o funcionamento do sistema aplicado à descrição de um acervo modelar. Para a experiência foi escolhido um acervo pertencente à Faculdade de Filosofia e Ciencias da Universidade Estadual Paulista, a UNESP. Foram, para isso, consideradas as necessidades de representação, e registradas em simulacros digitais de fichas descritivas, segundo modelo elaborado pelo CIDOC – com as customizações necessárias para o re-design de campos não atendidos pelo AtoM na Curadoria Digital, com vistas a propiciar a sua representação e disponibilização em ambientes digitais da Web2.0. / This project has, as object of study and customization, the software Access to Memory (AtoM), a system for description and representation of archival collections applied to the documentation department of a historical museum. The purpose of this application is to study the adaptation and use of AtoM in documentary production and representation of objects in museological institutions of diverse and heterogeneous collections. The system AtoM, originated from an agreement between the International Council on Archives and the group Artefactual, provides the description of memory collections and their consequent representation in archival institutions, giving information access to these collections. In this project, we seek to contribute to Information Science (IS) and Museology regarding the possibilities of access, sharing and interaction of the subjects with the information kept by these institutions, since the new potentialities of AtoM in the context of museums allow customizing the standardized description of objects and interoperability across systems. The initiative is justified by its social relevance once open, free and customizable software, such as the AtoM, with potentialities of horizontal information treatment allow a type of conversation among individuals, turning them into protagonists of their stories. Thus, an interdisciplinary investigation was carried out between IS and Museology and, then, a compilation of the concepts and themes listed for an optimal use of the system in a museum environment, considering the representative needs of the museum collections in Brazil, which can only count with proprietary software for representation and cataloging. A participatory exploration was also carried out in the AtoM in order to understand the operation of the system applied to the description of the model collection. For the experience, the collection belonging to Faculdade de Filosofia e Ciencias da Universidade Estadual Paulista, UNESP, was chosen. The needs for representation recorded in digital representations of descriptive cards - according to the model elaborated by CIDOC - were considered, with the necessary customizations for the re-design of the fields not served by the AtoM in the Digital Curation, aiming to provide its representation and access in Web2.0 digital environments.

nÃo hà / O atual crescimento exponencial na produÃÃo de dados à resultado do desenvolvimento e uso de Tecnologias digitais de InformaÃÃo e de ComunicaÃÃo. Neste cenÃrio, o fenÃmeno conhecido como Big Data, promove a produÃÃo de objetos digitais em uma escala nunca antes vista, trazendo a tona o desafio de manter e preservÃ-los. Diante disto, a curadoria digital propÃe aÃÃes para cuidar e salvaguardar dados em sistemas automatizados oferecendo condiÃÃes para seu reÃso e acesso futuro. Em um conceito ressignificado, a curadoria com a predicaÃÃo digital atua por meio de um ciclo de vida com o objetivo de garantir que as aÃÃes necessÃrias à gestÃo e preservaÃÃo sejam devidamente implementadas. Dentre os ambientes digitais, o repositÃrio à apresentado como um sistema de informaÃÃo com estrutura capaz de armazenar e disseminar os dados de forma eficiente. Diante disso, o estudo se propÃs a identificar e avaliar o processo de curadoria digital de documentos acadÃmicos produzidos por uma InstituiÃÃo de Ensino Superior, localizada em Fortaleza, sob a Ãtica do ciclo de vida dos dados (CVD-CI) de SantâAna. Por meio dos objetivos especÃficos, foi possÃvel verificar a gestÃo (tecnologia, processos e equipe) de documentos acadÃmicos da instituiÃÃo escolhida; verificar a estrutura e o planejamento dos seus ambientes digitais e; analisar aÃÃes de curadoria sob a perspectiva das etapas do ciclo de vida escolhido. A metodologia empregada, pauta-se na abordagem qualitativa, tendo sido feito um estudo de caso da gestÃo e preservaÃÃo de documentos digitais produzidos na instituiÃÃo pesquisada. Os instrumentos utilizados na coleta de dados foram entrevistas, anÃlise documental e observaÃÃo. As entrevistas foram aplicadas em um grupo focal com bibliotecÃrios e um analista de tecnologia, realizadas em duas fases, a primeira sobre o ambiente digital e segunda sobre os objetos digitais. De forma separada, tambÃm foi realizada uma entrevista com o analista de tecnologia para verificaÃÃo da infraestrutura tecnolÃgica e o processo de implantaÃÃo do DSpace na InstituiÃÃo. Os encontros foram registrados em Ãudio e com anotaÃÃes complementares em um caderno de pesquisa. O foco de anÃlise concentrou-se nos dados e ambiente digital da instituiÃÃo, tendo-se verificado as etapas do ciclo de SantâAna. Os corpora da pesquisa foram: Trabalhos de ConclusÃo de Cursos da GraduaÃÃo, DissertaÃÃes e Teses, e como ambiente, o sistema de gestÃo da biblioteca e o DSpace. A anÃlise dos dados apresentou as categorias de coleta, armazenamento, recuperaÃÃo e descarte, orientadas pelo ciclo de vida de SantâAna, para identificar quais foram aÃÃes realizadas pela instituiÃÃo e se necessitavam de melhorias. Os resultados foram embasados pela literatura e permitiram a elaboraÃÃo de sugestÃes como a necessidade de utilizar um mecanismo de coleta automatizado. Como conclusÃo, apresentaram-se algumas estratÃgias de soluÃÃes para a melhoria da curadoria dos documentos acadÃmicos digitais na instituiÃÃo, dentre elas a mudanÃa do fluxo de catalogaÃÃo da insituiÃÃo; utilizaÃÃo de um software para apoio na PreservaÃÃo Digital e a criaÃÃo de uma polÃtica de conteÃdos digitais.

Submitted by Renata Lopes (renatasil82@gmail.com) on 2018-11-07T16:54:36Z No. of bitstreams: 1 isadoramariliademoreiraalmeida.pdf: 41398585 bytes, checksum: 34a19013a7640322412b0cb6924c9345 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-11-23T13:18:10Z (GMT) No. of bitstreams: 1 isadoramariliademoreiraalmeida.pdf: 41398585 bytes, checksum: 34a19013a7640322412b0cb6924c9345 (MD5) / Made available in DSpace on 2018-11-23T13:18:10Z (GMT). No. of bitstreams: 1 isadoramariliademoreiraalmeida.pdf: 41398585 bytes, checksum: 34a19013a7640322412b0cb6924c9345 (MD5) Previous issue date: 2018-10-03 / A presente dissertação realiza uma trajetória, que discute tanto a dificuldade ainda existente em vermos obras de arte feita por mulheres, como também o entendimento de que o olhar feminino possibilita outra forma de enxergar o mundo. As mulheres artistas buscaram alternativas para exibir suas obras, sejam elas fotografias, colagens, pinturas, ilustrações e vídeos. Abordando justamente meios alternativos, tais como, a cultura da mail art, dos zines e atualmente as redes sociais, estes nos mostram uma circulação paralela de arte fora dos museus, em que artistas cada vez mais jovens propõem dividir seus olhares com o público. As tecnologias disponibilizadas pela internet, hoje, são em grande parte utilizadas por artistas para conquistarem visibilidade, e podemos entendê-las como ferramentas que contribuem com essa nova forma de exibição e experimentação dos espaços. Reunimos momentos particulares, sem preocupação historiográfica, que compuseram uma narrativa feminista cujas abordagens inspiraram novas artistas a partir dos anos de 2010, e culminaram em uma tentativa de curadoria com temáticas que versam sobre experiências, intimidades e outramentos. / The present dissertation follows a trajectory which discusses both the difficulty in seeing works of art made by women, as well understanding that female gaze allows another way of seeing the world. Women artists looked for alternatives to display their works, being these, photos, collages, paintings, illustrations and videos. Approaching the alternative media such as the culture of mail art, the zines and nowadays social networks, this study show us a parallel circulation of art outside the museums, in which increasingly younger artists propose to share their gaze with the public. The technologies available over the internet today are largely used by artists to gain visibility, and we can understand them as tools that contribute to this new way of exhibiting and experimenting of spaces. We put particular moments together, without historiographical concern, that composed a feminist narrative whose approaches inspired new artists from the years of 2010, and culminated in an attempt of curation with themes that deal with experiences, intimacies and othering ourselves.

Philosophiae Doctor - PhD / This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source Glossina resource (G-ESTMAP) was developed that provides interactive features and browsing of functional genomics data for researchers working in the field of Trypanosomiasis on the African continent. / South Africa

Non-coding RNAs are the most abundant class of RNAs found throughout genomes. These RNAs are key players of gene regulation and thus, the func- tion of whole organisms. Numerous methods have been developed so far for detecting novel classes of ncRNAs or finding homologs to the known ones. Because of their abundance, the sequence availability of these RNAs is rapidly increasing, as is the case for example for microRNAs. However, for classes of them, still only incomplete information is available, invertebrates 7SK snRNA for instance. Consequently, a lot of false positive outputs are produced in the former case, and more accurate annotation methods are needed for the latter cases to improve derivable knowledge. This makes the accuracy of gathering correct homologs a challenging task and it leads directly to a not less important problem, the curation of these data. Finding solutions for the aforementioned problems is more complex than one would expect as these RNAs are characterized not only by sequences informa- tion but also structure information, in addition to distinct biological features. In this work, data curation methods and sensitive homology search are shown as complementary methods to solve these problems. A careful curation and annotation method revealed new structural information in the invertebrates 7SK snRNA, which pushes the investigation in the area forward. This has been reflected by detecting new high potential 7SK RNA genes in different invertebrates groups. Moreover, the gaps between homology search and well- curated data on the one side, and between experimental and computational outputs on the other side, are closed. These gaps were bridged by a curation method applied to the microRNA data, which was then turned into a com- prehensive workflow implemented into an automated pipeline. MIRfix is a microRNA curation pipeline considering the detailed sequence and structure information of the metazoan microRNAs, together with biological features related to the microRNA biogenesis. Moreover, this pipeline can be integrated into existing methods and tools related to microRNA homology search and data curation. The application of this pipeline on the biggest open source microRNA database revealed its high capacity in detecting wrong annotated pre-miRNA, eventually improving alignment quality of the majority of the available data. Additionally, it was tested with artificial datasets highlighting the high accuracy in predicting the pre-miRNA components, miRNA and miRNA*.:Chapter 1: Introduction Chapter 2: Biological and Computational background 2.1 Biology 2.1.1 Non-coding RNAs 2.1.2 RNA secondary structure 2.1.3 Homology versus similarity 2.1.4 Evolution 2.2 The role of computational biology 2.2.1 Alignment 2.2.1.1 Pairwise alignment 2.2.1.2 Multiple sequence alignment (MSA) 2.2.2 Homology search 2.2.2.1 Sequence-based 2.2.2.2 Structure-based 2.2.3 RNA secondary structure prediction Chapter 3: Careful curation for snRNA 3.1 Biological background 3.2 Introduction to the problem 3.3 Methods 3.3.1 Initial seeds and models construction 3.3.2 Models anatomy then merging 3.4 Results 3.4.1 Refined model of arthropod 7SK RNA 3.4.1.1 5’ Stem 3.4.1.2 Extension of Stem A 3.4.1.3 Novel stem B in invertebrates 3.4.1.4 3’ Stem 3.4.2 Invertebrates model conserves the HEXIM1 binding site 3.4.3 Computationally high potential 7SK RNA candidate . 3.4.4 Sensitivity of the final proposed model 3.5 Conclusion Chapter 4: Behind the scenes of microRNA driven regulation 4.1 Biological background 4.2 Databases and problems 4.3 MicroRNA detection and curation approaches Chapter 5: Initial microRNA curation 5.1 Introduction 5.2 Methods 5.2.1 Data pre-processing 5.2.2 Initial seeds creation 5.2.3 Main course 5.3 Results and discussion 5.4 Conclusion Chapter 6: MIRfix pipeline 6.1 Introduction 6.2 Methods 6.2.1 Inputs and Outputs 6.2.2 Prediction of the mature sequences 6.2.3 The original precursor and its alternative 6.2.4 The validation of the precursor 6.2.5 Alignment processing 6.3 Results and statistics 6.4 Applications 6.4.1 Real life examples and artificial data tests 6.4.2 miRNA and miRNA* prediction 6.4.3 Covariance models 6.5 Conclusion Chapter 7: Discussion