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Identification and characterization of human polycomb-group proteinsSatijn, David Pierre Elisabeth, January 2000 (has links)
Proefschrift Universiteit van Amsterdam. / Met bibliogr., lit. opg. - Met samenvatting in het Nederlands.
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Characterization of human polycomb-group complexes and their interacting proteinsSewalt, Richard George Antonius Bernardus. January 1900 (has links)
Proefschrift Universiteit van Amsterdam. / Met lit. opg. - Met samenvatting in het Nederlands.
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Einfluss gedächtnisrelevanter Prozesse auf die Glutamat- und GABA-Freisetzung aus hippocampalen PrimärkulturzellenHunzinger, Christian. January 2001 (has links) (PDF)
Mainz, Univ., Diss., 2001.
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Vývoj ultrastrukturálních metod a jejich použití pro studium buěčnénho jádra / Development of ultrastructural methods and their application in studies on the cell nucleusFilimonenko, Anatoly January 2014 (has links)
Despite the capabilities of molecular-biological methods in deciphering the interplay of different biological molecules and molecular complexes, the understanding of respective functions in living cells requires application of in situ methods. Obviously, these methods should provide maximal resolution and the best possible preservation of the biological object in a native state, as well as correct statistical evaluation of the spatial characteristics of detected molecular players. Transmission electron microscopy provides the highest possible resolution for analysis of biological samples. The simultaneous detection of biological molecules by means of indirect immunolabeling provides valuable information about their localization in cellular compartments and their possible interactions in macromolecular complexes. To analyze this, we have developed a complex stereological method for statistical evaluation of immunogold clustering and colocalization patterns of antigens on ultrathin sections, including a user-friendly interface. Functional microarchitecture of DNA replication and transcription sites has been successfully characterized using the developed stereological tools. Our data demonstrate that DNA replication is compartmentalized within cell nuclei at the level of DNA foci and support the view...
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