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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Investigations into the role of interleukin-8 in cystic fibrosis

Dai, Yalei January 1996 (has links)
No description available.

Glomerular gene transfer using genetically modified macrophages

Kluth, David Charles January 2001 (has links)
In this thesis I show that macrophages (both cell lines and primary cultures) can be transfected by recombinant adenoviruses expressing -galactosidase (A-gal/Av1Bng), that the macrophages become activated by the transfection process and can be easily manipulated to localise to inflamed glomeruli after direct injection into the renal artery of rats with an experimentally induced glomerular inflammation caused by nephrotoxic nephritis. The injection of transfected macrophages reduces the severity of injury in this model of glomerulonephritis as shown by a reduction in the degree of albuminuria. This approach provides a favourable system for gene delivery in inflammatory disease and shows that both the functional properties of the transfected macrophage as well the transgene it is engineered to produce are relevant for in vivo gene transfer. This approach has also been used to determine the effect of macrophages expressing active TGF-1 on the development of glomerular inflammation. TGF-1 expressing macrophages localised efficiently to inflamed glomeruli and produced the cytokine in vivo. These cells produced a reduction in the level of albuminuria compared to unmodified disease but not in comparison to injection of macrophages transfected with adenovirus expressing -galactosidase. In addition there was no alteration in the infiltration by ED1 positive macrophages. Thus TGF-1 expressed in this manner appears unable to significantly modulate glomerular inflammatory disease and the potential reasons for this are discussed. The system I have developed of macrophage transfection and delivery provides a valuable approach to study and modulate inflammatory disease.

Étude des effets anti-cytokines et anti-cataboliques des rétinoïdes sur les fibroblastes synoviaux et les chondrocytes de rat ou humains stimulés par de l'Interleukine-1 Bêta

Kirchmeyer, Mélanie Jouzeau, Jean-Yves. Bianchi, Arnaud. January 2008 (has links) (PDF)
Thèse de doctorat : Pharmacologie : Nancy 1 : 2008. / Titre provenant de l'écran-titre.

Experimental studies on effects of orthodontic forces in generation of immune responses : possible roles for immunoregulating molecules in the control of alveolar bone remodeling /

AL-Hashimi, Najat AL-Sayed, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.

Immunomodulation and immunopathogenesis in the autoimmune disease with emphasis on autoimmune neuritis and arthritis /

Bao, Lei, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.

Chlamydia pneumoniae and airways inflammation : an investigation of the host cell-pathogen relationship /

McNamara, Tracy Renee. January 2004 (has links) (PDF)
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2005. / "December 2004" Includes bibliographical references (leaves 342-379).

Prostaglandin E₂ in immune-to-brain signaling /

Engblom, David January 2003 (has links) (PDF)
Diss. (sammanfattning) Linköping : Univ., 2003. / Härtill 6 uppsatser.

Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide /

Ungerstedt, Johanna S. , January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Pharmacology, epidemiology, and bioactivites of tocopherols and their metabolites in human and non-human models for inflammatory disease

Williamson, Kelly Scott. January 2008 (has links) (PDF)
Thesis (Ph. D.)--University of Oklahoma. / Bibliography: leaves 234-253.

Effects of daily versus 30-day continuous contact lens wear on tear cytokine levels

Kehinde, Lucy E. January 2009 (has links) (PDF)
Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from PDF title page (viewed on Sept 9, 2009). Includes bibliographical references (p. 120-125).

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