This thesis deals myopotential denoising of ECG signals with using wavelet transform. There was used wavelet denoising subsequently wiener wavelet filtering. In both cases were found the most suitable coeficients for the best denoising. It is meant mainly settings suitable parameters for ideal filtration setting value of threshold, number of decomposition level, selection of thresholding and type of filter. These parameters are tested on real signals. Denoising is realized in Matlab version R2009b.