Diss.--Philosophische Fakultät--Kiel--Christian-Albrechts-Universität, 1994. / Bibliographie p. 339-366.

Zugl.: Köln, Universiẗat, Diss., 1994.

Series: SRE - Discussion Papers

Unfallforschung kommunal, Unfallforschung der Versicherer, GDV

No description available.

Traditional fashion retailers are increasingly hard-pressed to keep up with their digital competitors. In this context, the re-invention of brick-and-mortar stores as smart retail environments is being touted as a crucial step towards regaining a competitive edge. This thesis describes a design-oriented research project that deals with automated product tracking on the sales floor and presents three smart fashion store applications that are tied to such localization information: (i) an electronic article surveillance (EAS) system that distinguishes between theft and non-theft events, (ii) an automated checkout system that detects customers’ purchases when they are leaving the store and associates them with individual shopping baskets to automatically initiate payment processes, and (iii) a smart fitting room that detects the items customers bring into individual cabins and identifies the items they are currently most interested in to offer additional customer services (e.g., product recommendations or omnichannel services). The implementation of such cyberphysical systems in established retail environments is challenging, as architectural constraints, well-established customer processes, and customer expectations regarding privacy and convenience pose challenges to system design. To overcome these challenges, this thesis leverages Radio Frequency Identification (RFID) technology and machine learning techniques to address the different detection tasks. To optimally configure the systems and draw robust conclusions regarding their economic value contribution, beyond technological performance criteria, this thesis furthermore introduces a service operations model that allows mapping the systems’ technical detection characteristics to business relevant metrics such as service quality and profitability. This analytical model reveals that the same system component for the detection of object transitions is well suited for the EAS application but does not have the necessary high detection accuracy to be used as a component of an automated checkout system. / Das fortschreitende Wachstum des Online-Handels setzt traditionelle Modehändler zunehmend unter Druck. Als entscheidender Schritt zur Rückgewinnung von Kunden wird die Transformation traditioneller Ladengeschäfte hin zu intelligenten Ladenumgebungen gesehen. Die vorliegende gestaltungsorientierte Arbeit beschäftigt sich mit der automatischen Verfolgung von Produkten auf der Verkaufsfläche und stellt drei intelligente Anwendungen vor, die auf derartige Informationen angewiesen sind: (i) ein Diebstahlsicherungssystem, (ii) ein System zur Automatisierung des Kassiervorgangs und (iii) eine intelligente Umkleidekabine. Das erste System erkennt Produkte mit denen Kunden die Verkaufsfläche verlassen; das zweite System ordnet diese zusätzlich den richtigen Warenkörben zu. Das dritte System erkennt die Produkte, die ein Kunde in eine Umkleidekabine bringt und identifiziert, basierend auf der Interaktion des Kunden mit den Produkten, an welchem Produkt er aktuell am meisten Interesse hat. Zu diesem sollen anschließend maßgeschneiderte Dienste angeboten werden (z.B. Produktempfehlungen). Die Einbettung derartiger cyber-physischer Systeme in bestehende Einzelhandelsumgebungen ist aufgrund architektonischer Einschränkungen, etablierten Kundenprozessen und Kundenerwartungen hinsichtlich Datenschutz und Einkaufskomfort mit zahlreichen Herausforderungen verbunden. Zur Lösung der einzelnen Erkennungsaufgaben untersucht die Arbeit den Einsatz von RFID-Technologie und maschinellen Lernverfahren. Um die Systeme zudem optimal zu konfigurieren und belastbare Aussagen über den Wertbeitrag dieser zu treffen, wird zudem ein analytisches Modell vorgestellt, welches es ermöglicht die technischen Erkennungsmerkmale der Systeme auf geschäftsrelevante Kennzahlen wie Servicequalität und Rentabilität abzubilden. Die Bewertung der Systeme mit diesem Modell zeigt, dass die gleiche Systemkomponente zur Erkennung von Objektübergängen als Komponente eines Diebstahlsicherungssystems geeignet ist, jedoch nicht die erforderliche Erkennungsgenauigkeit aufweist, um als Komponente eines Systems zu Automatisierung des Kassiervorgangs verwendet werden zu können.

Most cases of Van der Woude syndrome are caused by a mutation to interferon regulatory factor 6 on chromosome 1. Turner syndrome is caused by complete or partial absence of the second sex chromosome in girls. We describe a unique case of the two syndromes occurring concurrently though apparently independently in a girl with Van der Woude syndrome diagnosed at birth and Turner syndrome at 14 years 9 months. Short stature was initially misattributed to Van der Woude syndrome and pituitary insufficiency associated with clefts before correctly diagnosing Turner syndrome. We discuss the prevalence of delayed diagnosis of Turner syndrome, the rarity of reports of concurrent autosomal chromosome mutation and sex chromosome deletion, as well as the need to consider the diagnosis of Turner syndrome in all girls with short stature regardless of prior medical history.

The process of decoding is the most crucial determinant of the quality of protein synthesis. Ribosomal protein L9 was first implicated in decoding fidelity when a mutant version of L9 was found to increase the translation of a T4 phage gene. Later studies confirmed that the absence of L9 leads to increased translational bypassing, frameshifting, and stop codon readthrough. L9 is part of the large subunit of the prokaryotic ribosome and is located more than 90 Å from the site of decoding, making it difficult to envision how it might affect decoding and reading frame maintenance. Twenty years after the identification of L9's putative function, there is no mechanism for how a remotely located L9 improves translation fidelity. This mystery makes our picture of translation incomplete. Despite the high conservation of L9 in eubacteria, E.coli lacking L9 does not exhibit any obvious growth defects. Thus, the evolutionary advantage conferred by L9 in bacteria is masked under laboratory conditions. In order to uncover unique L9-dependent conditions, a library of E. coli mutants was screened to isolate those that rely on L9 for fitness. Interestingly, factors found to be synergistic with L9 had no known role in fidelity. Six independent mutants were isolated, each exhibiting a severe growth defect that is partially suppressed in the presence of L9. One class of L9-dependent mutations was present in an essential ribosome biogenesis factor, Der. Der's established function is in the maturation of the large ribosomal subunit. The identified mutations severely impaired the GTPase activity of Der. Interestingly, L9 did not directly compensate for the defective GTPase activity of mutant Der. The second class of L9-dependent mutations was present in EpmA and EpmB, factors required to post-translationally modify elongation factor, EF-P. EF-P's established function is in the translation of poly-proline containing proteins. EF-P deficient cells were nearly inviable in the absence of L9; however, L9 did not directly influence poly-proline translation. Therefore, in each case, L9 improved cell health without altering the activity of either Der or EF-P. Remarkably, the der mutants required only the N domain of L9, whereas the absence of active EF-P required full-length, wild-type L9 for growth complementation. Thus, each mutant class needed a different aspect of L9's unique architecture. In cells lacking either active EF-P or Der, there was a severe deficiency of 70S ribosomes and the indication of small subunit maturation defects, both of which worsened upon L9 depletion. These results strongly suggest that L9 plays a role in improving ribosome quality and abundance under certain conditions. Overall, the genetic screen lead to the discovery that bacteria need L9 when either of two important translation factors (Der or EF-P) is inactivated. This work has characterized the physiological requirement for L9 in each case and offers a new insight into L9's assigned role in translation fidelity.

No description available.

No description available.