Techniques of performance-based design in fire safety have developed notably in the past two decades. One of the reasons for departing from the prescriptive methods is the ability of performance-based methods to form a scientific basis for the cost-risk-benefit analysis of different fire safety alternatives. Apart from few exceptions, observation of past fires has shown that the structure’s contribution to the overall fire resistance was considerably underestimated. The purpose of this research is to outline a risk-based design approach for structures in fire. Probabilistic methods are employed to ascertain uniform reliability indices in line with the classical trend in code development. Modern design codes for complex phenomena such as fire have been structured to facilitate design computations. Prescriptive design methods specify fire protection methods for structural systems based on laboratory controlled and highly restrictive testing regimes. Those methods inherently assume that the tested elements behave similarly in real structures irrespective of their loading, location or boundary conditions. This approach is contested by many researchers, and analyses following fire incidents indicated alarming discrepancy between anticipated and actual structural behaviour during real fires. In formulating design and construction codes, code writers deal with the inherent uncertainties by setting a ceiling to the potential risk of failure. The latter process is implemented by specifying safety parameters, that are derived via probabilistic techniques aimed at harmonising the risks ensuing different load scenarios. The code structure addresses the probability of failure with adequate detail and accuracy. The other component of the risk metric, namely the consequence of failure, is a subjective field that assumes a multitude of variables depending on the context of the problem. In codified structural design, the severity of failure is implicitly embodied in the different magnitudes of safety indices applied to different modes of structural response. This project introduces a risk-based method for the design of structures in fire. It provides a coherent approach to a quantified treatment of risk elements that meets the demands of performance-based fire safety methods. A number of proposals are made for rational acceptable risk and reliability parameters in addition to a damage index with applications in structural fire safety design. Although the example application of the proposed damage index is a structure subjected to fire effects, the same rationale can be easily applied to the assessment of structural damage due to other effects.