Background: Pediatric chronic pain is prevalent and comes with diagnostic uncertainty and biopsychosocial complexity. The literature significantly lacks evidence and clinical guidance to inform triage decisions to interdisciplinary pediatric chronic pain programs, which likely impacts timely and appropriate access to much needed interdisciplinary care. Purpose: To methodically conduct foundational investigation into triage within interdisciplinary pediatric chronic pain programs to develop a preliminary series of Clinical Decision Support (CDS) triage tools grounded in evidence to facilitate nurses' triage decision-making. Methods: A pragmatic, multi-method study was conducted and fundamentally guided by the Knowledge to Action Framework (KTA). Included studies involved: 1) A modified Delphi study to attain expert consensus on the diagnostic expectations of pediatric patients referred to interdisciplinary chronic pain programs; 2) A systematic review of multidimensional biopsychosocial tools used in the pediatric chronic pain population, guided by the Multidimensional Biobehavioral Model of Pediatric Pain; and 3) An explorative descriptive qualitative study guided by the Cognitive Continuum Theory (CCT) and the Theoretical Domains Framework (TDF) to explore and describe the decision-making practices of and contextual influences on nurses triaging patients to interdisciplinary pediatric chronic pain programs. Findings: Following two survey rounds, the Delphi study demonstrated consensus on 84% of diagnostic items and general agreement regarding the diagnostic expectations of referred patients. The systematic review revealed six valid and reliable multidimensional biopsychosocial tools and highlighted 84 significant relationships between pain and functional interference across 11 biopsychosocial variables. The qualitative study emphasized the leading and complex triage role nurses lead in interdisciplinary pediatric chronic pain programs, and comprehensively described the triage process and determinants of the triage decision. Conclusions: Findings from the three studies have been integrated into the preliminary development of a series of CDS triage tools to be used in interdisciplinary pediatric chronic pain programs. This series offers decision guidance to accept or redirect care based on diagnostic clarity and a strategy to prioritize access to interdisciplinary care based on biopsychosocial needs. To determine clinical utility and validity of the tool, future research will target end-users to finalize tool development.