Spelling suggestions: "subject:"diazine.""
1 |
Azobenzenes: Make, Measure, and RollStone, Ilana B. January 2021 (has links)
This dissertation describes the synthesis of novel, small molecule building blocks and the phenomena that are revealed when they are studied in unusual environments.
Chapter 1 is divided into two sections, serving as introductions for chapters 2-3 and 4-5 respectively. The first section introduces the scanning tunneling microscope break junction (STM-BJ) as a new environment for reaction chemistry. Chapter 2 describes a truly single molecule reaction in which azobenzenes are formed in the STM-BJ one molecule at a time. Chapter 3 describes an electrostatically driven Ullmann coupling reaction of biphenyl iodides in the STM-BJ. In contrast to the reaction described in chapter 2, this reaction occurs throughout the solution in the presence of an electric field that surrounds the nanoelectrodes.
The second half of chapter 1 provides a primer on the photoisomerization of azobenzenes, a class of small molecule dyes whose unique photochromic profile and switchable properties have been exploited across a wide range of fields. Chapter 4 introduces azobenzenes as photoswitchable ligands on superatomic clusters. Chapter 5 details the phenomenon and mechanism of white light driven rolling of Cu(I) isocyanoazobenzene crystals.
Finally, chapter 6 is a self-contained research project. It details an organocatalytic O₂-coupled oxidation platform that capitalizes on the capacity of hydrazines to undergo rapid autoxidation to diazenes.
|
2 |
Sinteza, strukturna, fizičko-hemijska i biološka karakterizacija novih N-heterocikličnih liganada i njihovih kompleksa sa jonima prelaznih metala / Synthesis, structural, physico-chemical and biological characterization of N-heterocyclic ligands and their complexes with transition metal ionsMađari Jožef 08 October 2018 (has links)
<p>Opisane su sinteze novih liganada bis(ftalazin-1hidrazon)-2,6-diacetilpiridna (Hz<sub>2</sub>DAP·2HCl), bis(3-hlorpiridazin-6-hidrazon)-2,6-diacetilpiridina (Hp<sub>2</sub>DAP), 3-hlorpiridazin-6-hidrazon di(2-piridil) ketona (HpDPK), ftalazin-1-hidrazon di(2-piridil)<br />ketona (HzDPK) i ftalazin-1-hidrazon piridin-2-karbaldehida (HzPY). Zajedničko svojstvo dobijenih liganada je što sadrže piridinski i diazinski prsten i sadrže samo donorne atome azota. Tokom nastajanja kompleksa dolazi do deprotonacije liganada. Svi ligandi su okarakterisani elementalnom analizom, termoanalitičkim metodama i metodom IR spektroskopije, dok neki i metodom NMR spektroskopije kao i rendgenskom strukturnom analizom.Za sintezu koordinacionih jedinjenja primenjeni soli Co(II), Ni(II), Cu(II) i Zn(II). Dobijeni kompleksi su okarakterisani elementalnom analizom, konduktomerijskim i magnetnim merenjima, IR spektroskopijom i termoanalitičkim metodama. Barem jedan kompleks iz svake serije je okarakterisan i rendgenskom strukturnom analizom. Urađena su i ispitivanja antimikrobne aktivnosti odabranih jedinjenja prema predstavnicima grampozitivnih i gram-negativnih bakterija i kulturu kvasca. Pored toga, urađena su i ispitivanja citotoksične,antiproliferativne i inhibitorne aktivnosti jedinjenja prema roditeljskim i multirezistentnim T-limfomnim ćelijama kancera. Utvrđeno je da neka jedinjenja pokazuju izrazito mikrobicidno, citotoksično, antiproliferativno i inhibitorno dejstvo.</p> / <p>The synthesis of new ligands dihydrochloride salt of 2,6-diacetylpyridne bis(phthalazine-1hydrazone) (Hz<sub>2</sub>DAP•2HCl), 2,6-diacetylpiridine bis(3- chloropyridazine-6-hydrazone) (Hp<sub>2</sub>DAP), di(2-pyridyl)ketone 3-chloropyridazine- 6-hydrazone (HpDPK), di(2-pyridyl)ketone phthalazine-1-hydrazone (HzDPK) and pyridine-2-carbaldehide phthalazine-1-hydrazone (HzPY) have been described. All the ligands contain pyridine and diazine core and all of them have only nitrogen donor atoms. During the complex formation the deprotonation of ligands takes places. All of the ligands have been characterized by elemental analysis,thermoanalytical methods and IR spectroscopy. In some cases also by NMR spectroscopy and X-ray structural analysis.Co(II), Ni(II), Cu(II) and Zn(II) salts were used for the synthesis of the coordinational compounds. The obtained complexes were characterized by elemental analysis, molar conductivity and magnetic measurements, IR spectroscopy and thermoanalytical methods. At least one complex of each series were characterized by X-ray structural analysis.The antimicrobial activity of some of the compounds toward Gram-positive/Gram- negative bacteria furthermore, the cytotoxic, antiproliferative and inhibitory activity toward sensitive parental andmultiresistant T-lymphoma cancer cells have also been carried out. It can be concluded that some of the compounds exhibit outstanding antimicrobial, cytotoxic, antiproliferative, and inhibitory activity.</p>
|
Page generated in 0.0321 seconds