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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Estudo do perfil lipidico em uma população de mulheres gerontes, portadoras de hipotiroidismo subclinico / Lipid profile study in elderly women with subclinical hypothyroidism

Peterson, José Carlos Bellini, 1947- 12 April 2007 (has links)
Orientador: Maria Helena Guariento / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação / Made available in DSpace on 2018-08-10T19:38:48Z (GMT). No. of bitstreams: 1 Peterson_JoseCarlosBellini_M.pdf: 573106 bytes, checksum: 27eae8ac4d3d6adff5223f3ae8b46ffc (MD5) Previous issue date: 2007 / Resumo: O hipotireoidismo subclínico (HTSC) é uma enfermidade caracterizada pelo aumento dos níveis de hormônio tireoestimulante associado a níveis normais de tiroxina livre, habitualmente sem sinais e sintomas do hipotireoidismo clinicamente manifesto (HTC). A literatura mostra prevalência mais alta de HTSC em mulheres e nos mais idosos. No presente trabalho, estudou-se 76 mulheres portadoras de HTSC, com 65 anos ou mais, seguidas no Ambulatório de Endocrinologia da Faculdade de Medicina de Jundiaí, São Paulo. Foram excluídas mulheres com idade inferior a 65 anos, pacientes com diagnóstico prévio de HTC e HTSC em tratamento, Diabetes Mellitus ou outra endocrinopatia que possa cursar com elevação dos níveis lipídicos , hepatopatias, alcoolismo, nefropatias, tabagismo, uso de drogas hiperlipemiantes e pacientes com antecedentes de Doença Vascular Aterosclerótica (DVA). Avaliou-se: idade: 70.43 ± 4.84 anos; IMC: 27.52 ± 3.07 kg/m², pressão arterial sistólica (PAS): 136.97 ± 17.44 mmHg; pressão arterial diastólica (PAD): 87.89 ± 10.87 mmHg; tiroxina livre (T4L): 1.28 ± 0.25 ng/dl; hormônio tireo-estimulante (TSH): 12.41 ± 11.19 mIU/L; colesterol total (CT): 257.12 ± 61.22 mg/dl; HDL-colesterol (HDL-c): 39.30 ± 8.78 mg/dl; LDL-colesterol (LDL-c): 146.49 ± 42.94 mg/dl; VLDL-colesterol (VLDL-c): 41.13 ± 27.41 mg/dl e triglicérides (TG): 224.46 ± 123.30 mg/dl. Foi feito o estudo dos perfis clínico-laboratoriais presentes nesse grupo de pacientes, através da análise comparativa dos agrupamentos, que mostrou a existência de dois perfis: 1. Mulheres idosas com HTSC com maior valor de T4L e HDL-c e menor valor de TSH, CT, TG, LDLc, VLDL-c, CT/HDL-c e LDL/HDL-c; 2. Mulheres idosas com HTSC com valor menor de T4L e HDL-c e maior valor de TSH, CT, TG, LDLc, VLDL-c, CT/HDL-c e LDL/HDL-c. A aparente relação entre HTSC e dislipidemia resultou em uma elevada relação CT/HDL-c (p < 0.001) e também na relação LDL-c/HDL-c (p < 0.001) no subgrupo 2, o que traduz um risco cardiovascular aumentado, associado à DVA. Em conclusão, o estudo relaciona o HTSC em um grupo de mulheres idosas com a dislipidemia, mostrando dois perfis endócrinometabólicos, com risco de desenvolvimento de aterosclerose mais elevado naquele que apresenta menores valores de T4L e HDL-c / Abstract: Subclinical hypothyroidism (SCH) is a disease characterized by an increase in the thyrostimulating hormone (TSH), which is associated to normal levels of free thyroxin (FT4), which frequently does not present signs and symptoms of clinically manifested hypothyroidism. Literature reports a higher prevalence in women and elderly people. In this work, 76 elderly women with SCH were studied in the Endocrinology Clinic of FMJ - Jundiaí (São Paulo, Brazil), excluding patients in treatment to hypothyroidism and who presented other endocrinopathy or conditions that cause dyslipidemia. They were analyzed according to: Age (Average ± OR): (70.43±4.84), BMI (27.52±3.07), Systolic Blood Pressure (136.97±17.44), Diastolic Blood Pressure (87.89±10.87), FT4 (1.28±0.25), TSH (12.41±11.19), Total Cholesterol (TC) (257.12±61.22), HDL-c (39.30±8.78), LDL-c (146.49±42.94), VLDL-c (41.13±27.41) and Triglycerides (224.46±123.30). The clinical-laboratorial profiles present in this group was carried out through the clusters¿ comparative analysis, demonstrating the existence of two profiles: 1. Higher levels of FT4 and HDL-c and lower levels of TSH, CT, TG, LDL-c, VLDL-c, CT/HDLc and LDL/HDL-c; 2. Lower levels of FT4 and HDL-c and higher levels of TSH, CT, TG, LDL-c, VLDL-c, CT/HDL-c and LDL/HDL-c. The apparent relationship between SCH and dyslipidemia resulted in a high CT/HDL-c (p<0.001) and LDL-c/HDL-c (p<0.001) ratios in subgroup 2, which implies in increased cardiovascular risk, due to atherosclerotic vascular disease (AVD). In conclusion, this study relates SCH with dyslipidemia in a group of elderly women, revealing two endocrine-metabolic profiles, in which that with smaller FT4 and HDL-c levels presents a higher risk of developing atherosclerosis / Mestrado / Gerontologia / Mestre em Educação

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