The differentiation, in an infant with cholestasis, between extrahepatic biliary atresia (EHBA) and the neonatal hepatitis syndrome (NHS) is important in that laparotomy is always indicated in EHBA but is undesirable in NHS. This differentiation is particularly difficult in those infants with complete cholestasis. Hepatobiliary scintigraphy is a commonly used investigation in infants with obstructive jaundice. The scintigraphic demonstration of excretion into the gut excludes extrahepatic obstruction, however, absence of excretion may be due to EHBA, severe cholestasis with patent extrahepatic bile ducts or poor uptake of the agent, and is therefore not diagnostic. This study has examined the quantitative measurement of the hepatic uptake of p-butyl IDA and Sn colloid, and an estimation of liver shape, in a group of patients with complete cholestasis in whom conventional scan interpretation, based on excretion into the-gut, would not be useful. The scans were recorded as dynamic studies and the resultant time-activity curves were subjected to curve fitting to calculate a rate constant for uptake of radiopharmaceutical. Liver shape was determined from the anterior static image of the colloid scan. The results show a significant difference between the EHBA and the NHS patients in the rate of uptake of p-butyl IDA, in the ratio of the rate of uptake of p-butyl IDA/the rate of uptake of colloid and in the measurements used to express liver shape. Using this method of scan interpretation, a diagnostic accuracy of 85% was achieved in this study of patients who clinically, and on scan, had no evidence of bile flow. Hepatic scintigraphy is therefore a useful investigation in the diagnostic work-up of infants presenting with obstructive jaundice even when bile flow is completely absent.

No abstract provided. / Thesis / Master of Engineering (MEngr) / Scope and contents: This thesis describes the behaviour of iron ore-water suspensions under turbulent flow conditions. This work is divided into two parts. Part I deals with the regimes of transport under steady state flow conditions in circular and horizontal ducts. The heterogeneous flow regime is extensively analyzed; a sequential discrimination of models with an oriented design of experiments have permitted the determination of the best model to correlate hydraulic gradients for these suspensions. A critical discussion on the limit deposit conditions is also included. Part II describes the behaviour of clear water under oscillatory flow conditions. The study demonstrates that the quasi-steady state hypothesis, i.e., fully developed flow assumption, applied to pulsatile turbulent flow under the conditions studied. Observations on the behaviour of iron ore-water suspensions under pulsatile flow are also included. The experiments were carried out using a new air-pulsing technique.

La surveillance des rejets gazeux des installations nucléaires dans l'environnement et de contrôle des dispositifs d'épuration reposent sur des mesures régulières de concentrations des contaminants en sortie de cheminées et dans les réseaux de ventilation. La répartition de la concentration peut être hétérogène au niveau du point de mesure si la distance d'établissement du mélange est insuffisante. La question se pose sur l'évaluation du positionnement des points de piquage et sur l'erreur commise par rapport à la concentration homogène en cas de non-respect de cette distance. Cette étude définit cette longueur dite de « bon mélange » à partir d'expériences menées en laboratoire. Le banc dimensionné pour ces essais a permis de reproduire des écoulements dans des conduits longs circulaire et rectangulaire, comprenant chacun un coude. Une technique de mesure optique a été développée, calibrée puis utilisée pour mesurer la distribution de la concentration d'un traceur injecté dans l'écoulement. Les résultats expérimentaux en conduit cylindrique ont validé un modèle analytique basé sur l'équation de convection-diffusion d'un traceur, et ont permis de proposer des modèles de longueur de bon mélange et de représentativité de points de prélèvement. Dans le conduit à section rectangulaire, les mesures acquises constituent une première base de données sur l'évolution de l'homogénéisation d'un traceur, dans la perspective de simulations numériques explorant des conditions plus réalistes des mesures in situ. / Monitoring of gaseous releases from nuclear installations in the environment and air cleaning efficiency measurement are based on regular measurements of concentrations of contaminants in outlet chimneys and ventilation systems. The concentration distribution may be heterogeneous at the measuring point if the distance setting of the mixing is not sufficient. The question is about the set up of the measuring point in duct and the error compared to the homogeneous concentration in case of non-compliance with this distance. This study defines the so-called "well mixing length" from laboratory experiments. The bench designed for these tests allowed to reproduce flows in long circular and rectangular ducts, each including a bend. An optical measurement technique has been developed, calibrated and used to measure the concentration distribution of a tracer injected in the flow. The experimental results in cylindrical duct have validated an analytical model based on the convection-diffusion equation of a tracer, and allowed to propose models of good mixing length and representativeness of sampling points. In rectangular duct, the acquired measures constitute a first database on the evolution of the homogenization of a tracer, in the perspective of numerical simulations exploring more realistic conditions for measurements in situ.

During renovation Ljusåret 2 was converted to a modern office with an activity based work style (ABW) with a Demand Controlled Volume (DCV) ventilation system connected to a closed-loop duct. Cooling is provided through air handling units and active water based beams, the underfloor heating system was kept. Written instruction and specification have been studied for the two different control systems Schneider EcoStructure and Lindinspect. Both control systems have been analyzed according to time schedule, set-point and process value by using different functions in software. To be able to perform a energy audit and look at indoor climate for Ljusåret 2 there have been studies according to underfloor heating, constructions of ventilation system, diversity factor for DCV, closed-loop-ducts, heat losses from ducts, cooling demand and energy certification. According to this audit, energy performance is calculated to 89.1 kWh/m2 according to building energy, activity energy is not audited or calculated. During design phase, an energy calculation was made by an energy consultant with the result of 81.3 kWh/m2. The estimated performance is a 9.6 % increase. This building is designed for Miljöbyggnad certification of level silver and should be ≤ 109 kWh/m2,year. According to audit and calculation for energy performance this level is possible to keep. The estimated energy performance have been calculated with only 4 month of statistics from January until April 2019 because Ljusåret 2 have just been renovated. District heating has been estimated through the energy signature by data from energy meter. Electrical components for the building have been measured and energy usage calculated. Energy produced by compression chiller have been estimated with calculated performance from design phase and adding heat transfer between rooms and supply ducts. Energy between rooms and supply ducts were not included in energy calculation during the design phase. According to the control system for the DCV system there have been some issues with high temperature in supply ducts even when they are supplied with 15 ºC from air- handling unit. There have been measurement to the ventilation system 5701-5704 that is connected to a close-loop duct with a result of temperatures between 15.2 ºC up to 21.4 ºC and the velocity has varied between 0.05-2.1 m/s in different measurement spots. This is an increase of 6.4 ºC. A heat transfer calculation have been made in Paroc Calculus to estimate heat transfer between room and supply ducts. The results of this calculation indicates the same level of temperature increases as when the system was measured. With no thermal insulation cooling capacity is lost to half after less than 5 m with a velocity of 0.2 m/s, after 15 m with a velocity of 1 m/s and 30 m with a velocity of 2 m/s . This should be compared with supply duct with 20 mm of thermal insulation that has lost its cooling capacity after less than 13 m with a velocity of 0.2 m/s, after 63 m with a velocity of 1 m/s and is increase with 4 ºC after 100 m with a velocity of 2 m/s. Using closed-loop ducts with velocity below 2.0 m/s and without thermal insulation combined with under tempered supply air is not a good combination. Even short length with low velocity and lack of thermal insulation is devastating because of heat transfer according to logarithmical temperature difference between room and supply ducts. A closed-loop duct is often designed as a pressure chamber and recommended when using DCV and/or VAV ventilation to avoid problems with noise and to be able to reduce the need of dampers. Problems with temperature increasing according to velocity in ducts must be taken in consideration. For Ljusåret 2 this will affect district heating usage where ducts are placed because underfloor heating must compensate heat transfer. Chilled water must be provided an extra time for rooms with both DCV and chilled beams and rooms with only DCV is less comfortable which they could been with a correct installation.

Diss. Linköping : Linköpings universitet, 2005.

Orientador: Jose Roberto Nunhez / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica / Made available in DSpace on 2018-08-11T08:15:27Z (GMT). No. of bitstreams: 1 Lopes_GabrielaCantarelli_M.pdf: 1710566 bytes, checksum: efab0c6308734536b15c2ef91d4d8337 (MD5) Previous issue date: 2008 / Resumo: Processos que envolvem escoamentos de fluidos no interior de dutos estão presentes em muitas aplicações industriais. Na indústria petroquímica um desses processos que vem se tornando cada vez mais importante é o craqueamento catalítico de frações pesadas do petróleo, já que as converte em frações leves e mais nobres. Por causa da crescente demanda mundial por gasolina e GLP e à sua alta rentabilidade para uma refinaria de petróleo, unidades de craqueamento catalítico em leito fluidizado (FCC) estão presentes em todo o mundo. Testes experimentais costumam ser usados no estudo dos fenômenos envolvidos nesse processo. Porém esse tipo de análise possui alto custo, que pode ser reduzido com o uso de simulações computacionais em seu estudo inicial. Assim, o objetivo deste trabalho foi desenvolver um modelo tridimensional e elíptico, em linguagem Fortran, capaz de fornecer dados para a análise preliminar de escoamentos no interior de reatores de FCC. Na modelagem desses problemas são usadas equações diferenciais parciais, e essas não possuem solução analítica conhecida, sendo necessário o emprego de métodos numéricos para esse fim. Neste trabalho foi usado o Método dos Volumes Finitos, que tem a função de substituir as equações diferenciais parciais por equações algébricas aplicadas a pequenos volumes de controle finitos pertencentes ao domínio. Uma das maiores dificuldades encontradas no tratamento numérico de escoamentos incompressíveis é a determinação de um campo de pressão que satisfaça a Equação da Continuidade. Esse problema foi resolvido fazendo-se uso da abordagem acoplp.da de solução. Para análise do modelo foram obtidos perfis numéricos de velocidade e pressão para fluidos escoando em regimes laminar e turbulento, que foram validados usando-se os dados obtidos com a solução analítica das equações, por correlações (semi-) empíricas ou por dados experimentais, conforme cada um dos casos. Notou-se que o modelo representa muito bem casos laminares, e gue 11.oS casos turbulentos foi necessário um maior refino da malha próximo a parede do tubo. Também foram feitas simulações para que se pudessem observar as características tridimensionais, elípticas e transientes da modelagem do escoamento. De maneira geral o modelo se mostrou bastante rápido, convergindo em poucas iterações. Palavras-Chave: Fluidodinâmica computacional; dutos cilíndricos; modelo tridimensional e elíptico; método dos Volumes Finitos; solução acoplada; turbulência / Abstract: Processes involving fluid flow in tubes are present in many industrial applications. In petrochemical industry one of these processes that are becoming more and more important is the fluid catalytic cracking of heavy petroleum fractions. This fact is due to the process capacity to convert heavy fractions in light and valuable ones. Because of the increasingly worldwide demand for gasoline and LPG and its high yield for a petroleum refinery, fluid catalytic cracking (FCC) units are present in the whole world. Experimental tests are used in the study of the phenomena involved in this processo However this kind of analysis has high cost which can be reduced by using computational simulations in its initial study. Thus, the aim of this work was the development of a three-dimensional and elliptical mo dei in Fortran language in order to provide data for fluid flow preliminary analysis in FCC reactors. Partial differential equations were used in the modeling of these problems. These equations do not have known analytical solution, being necessary therefore the use of numerical methods. In this work the Finite Volume Method were applied with this purpose. This method has as a role to substitute the partial differential equations of the mo dei for algebric equations applied to small finite control volumes of the domain. One of the biggest difficulties found in the numerical treatment of incompressible fluid flows is the determination of apressure field that satisfies the Continuity Equation. This problem was solved using the coupled solution approach. For model analysis, numerical velocity and pressure proJ:iles for laminar and turbulent flows were obtained, that had been validated using the data obtained through the analytical solution of the equations, by empirical correlations or by experimental data, according to each one of the cases. The model represented well laminar cases, and in the turbulent ones the mesh had to be more refined near the tube wall. Other simulations were performed, in aQalyzing the three-dimensional, elliptical and transient model characteristics. In general, the mo dei was very fast, converging in a few interations. Keywords: Computational fluid dyn~mic; cylindrical ducts; three-dimensional and elliptical model; Finite Volume Method; coupled solution; turbulence / Mestrado / Desenvolvimento de Processos Químicos / Mestre em Engenharia Química

Le développement du tractus reproducteur femelle est issu de la coordination minutieuse de nombreuses voies de signalisation régulant les processus de prolifération, différenciation et d’apoptose cellulaire durant l’embryogenèse. Les voies Wnt et Hippo se démarquent à cet égard. L’activation de la voie Wnt, via des ligands spécifiques, participe à la stabilisation et l’augmentation de l’activité transcriptionnelle du coactivateur de transcription β-catenin. La voie Hippo, pour sa part, ne possède aucun de ligand spécifique. L’inactivation de la voie Hippo (via les kinases Lats1 et Lats2) entraine la stabilisation des coactivateurs de la transcription YAP/TAZ et l’augmentation de leur activité transcriptionnelle. Plusieurs évidences suggèrent notamment la possibilité de redondance fonctionnelle entre certains ligands de la voie Wnt, dont Wnt4 et Wnt5a, dans le développement du tractus reproducteur femelle. Cette avenue demeure toutefois peu étudiée. L’implication de la voie Hippo n’a pas été rapportée dans le développement du tractus reproducteur femelle. Toutefois, les nombreuses interactions rapportées dans la littérature entre les deux voies suggèrent un rôle méconnu de la voie Hippo. L’objectif de ce projet était donc d’élucider les rôles de Wnt4, Wnt5a, Lats1 et Lats2 dans le mésenchyme de Müller et le développement de l’utérus. Les résultats de notre première étude ont confirmé la fonction partiellement redondante de Wnt4 et Wnt5a dans le développement de l’utérus. Notre modèle est notamment caractérisé par des anomalies développementales ainsi qu’une perte de fonction utérine associée à des anomalies de décidualisation in vivo et une diminution de la viabilité des concepti. Les résultats de notre seconde étude ont confirmé les rôles redondants de Lats1 et Lats2 dans le maintien de la multipotentialité des cellules mésenchymateuses müllériennes. Une différenciation hâtive des cellules mésenchymateuses müllériennes en myofibroblastes via, entre autres, l’expression du gène cible Ctgf, a été observée. Nos résultats additionnels n’ont pu mettre en évidence une interaction potentielle entre les voies Wnt et Hippo pouvant expliquer l’apparition des phénotypes. Ces deux études permettent de confirmer certains rôles connus et d’établir de nouveaux rôles de ces voies dans le développement des canaux de Müller. Ils pourront aussi établir les fondements de modèles permettant l’étude de différentes pathologies utérines et l’identification de cibles thérapeutiques. / The development of the female reproductive tract arises from the coordination of numerous signaling pathways regulating processes such as proliferation, differentiation and apoptosis during embryogenesis. The Wnt and Hippo pathways are known to be involved in these processes. Wnt pathway activation, via its specific ligands, results in the stabilisation and increased transcriptional activity of β-catenin. The Hippo pathway does not possess any specific ligands. In contrast to Wnt, inactivation of the Hippo pathway (via Lats1 and Lats2 kinases) is required for the stabilization and increased activity of the transcriptional coactivators YAP and TAZ. The Wnt pathway is known to be involved in the development of the female reproductive tract. Further evidence also suggests the possibility of functional redundancy amongst certain WNT ligands such as Wnt4 and Wnt5a. The Hippo pathway is not known to be implicated in the development of the female reproductive tract. However, numerous interactions have been reported between both pathways, suggesting a possible unknown role of Hippo in that context. The objective of this project was to elucidate the roles of Wnt4, Wnt5a, Lats1 and Lats2 in the Müllerian mesenchyme and the development of the uterus. Results from our first study confirmed the partially redundant roles of Wnt4 and Wnt5a in the development of the uterus. Our model was notably characterized by developmental abnormalities and loss of uterine functions resulting in in vivo decidualization defects and loss of conceptus viability. Results from our second study confirmed the redundant roles of Lats1 and Lats2 in the maintenance of Müllerian mesenchymal cell multipotency. We observed premature differentiation of Müllerian mesenchymal cells into myofibroblasts in absence of both Lats1 and Lats2. These changes were in part due to the increased expression of the target gene Ctgf. Our additional results could not demonstrate any potential interactions between the Wnt and Hippo pathways that could explain the phenotypic changes. In conclusion, our studies confirmed and further discovered novel roles of these pathways in the development of the Müllerian ducts. These models could also lead to better understanding of the pathophysiology of certain uterine diseases and the discovery of potential therapeutic approaches.

The main objective of this Master´s thesis is the appropriate calculation proposal of pressure and discharge conditions in extensive ducts in unsteady flow. The calculation proposal was aimed at the conenction of two commercial programmes. Exacly the programme Ansis Fluent and Matlab, which deals with the connection of onedimensional (1D) calculation in Matlab and multidimensional (2D) calculation in Ansys Fluent programme. This Mastr’s thesis also deals with creation of the independent 1D model (Matlab, method of characteristic) and independent 2D model flow (Ansys Fluent, Inviscid model).

The master´s thesis deals with the design of two-stroke uniflow scavenged motorcycle engine according to patent František Pudil (PV 7018-80) 216305. The engine has been designed for using in off-road sport motorcycles. The objective of this thesis is to design the engine of this conception and to reveal benefits and defects of this concept by using this method. In this thesis the emphasis is put on design of the construction groups which are directly related to unconventional concept of engine. On the other hand, the parts which can be designed conventionally were solved marginally or were not solved at all. In the first part of the thesis there are thoroughly dicsussed expected benefits and disadvantages of this concept. Computational part focuses on valvetrain and porting of engine. Last part deals with design of engine parts.

In this thesis, the in-duct experimental methods for determining aeroacoustic N-ports of in-duct elements are discussed and improved. The scattering matrix determination methods and the related wave decomposition methods are evaluated from measurements in an empty duct carrying a mean flow. The improvements of a new over-determination method for the source part of the N-port is studied using simulations and measurements; in quiescent air as well as measurements of the flow associated noise of a mixer plate, here a triangular plate inserted at an angle in a duct. The new method is shown to improve suppression of random errors while no improvement is achieved for bias errors.   Further, the methods are applied in the study of two different aeroacoustic phenomena; one is the effect on the flow associated noise of the triangular plate achieved by varying the bending stiffness. For the most resilient plate tested, it is observed that when the Strouhal number of the flow noise coalesce with the Helmholtz number of a specific eigen-mode of the plate, the noise is drastically dampened. There is also a weaker broad band effect.   The other phenomena studied is the amplification and attenuation obtained for sound waves propagating in a T-junction of rectangular ducts. It is found that by adding only 10% of inflow in the side branch relative to that in the main branch, the amplification is heavily increased. By adding another 10% the amplification is again similar to that of no side branch flow. Adding further flow lessens the effects still. / QC 20101118 / Experimental characterization of aero-acoustic sources