The paper brings answers on the the question whether it is possible to measure the field of recruitment. Via quantifying the administrative process of recrutment, the paper reflects the savings of time and costs by using e-recruitment application (applicant tracking system ATS) and it searchs for the relationship between quality of hire and increase of company value and its profit.

Plants are fundamental to life on earth, crucially providing the basis of our food supply. As world population continues to grow, so too does the pressure on our agricultural systems, with one of the biggest challenges being the control of plant pathogens to ensure a healthy crop. The interaction between plant and pathogen is complex, with subtleties at the molecular level dictating the boundary between health and disease. This is exemplified by pathogen effectors; secreted proteins which enter the plant cell and interact with host targets to facilitate infection. AVR2 is one such effector, secreted by the oomycete pathogen Phytophthora infestans; the pathogen responsible for potato late blight. AVR2 interacts with a family of kelch-repeat containing phosphatases in potato, the BSLs, implicated in brassinosteroid pathway signalling – a major hormone signalling pathway in plants associated with growth and development. This work investigates the role of AVR2 and its host targets in pathogen virulence, with focus on the link between the brassinosteroid pathway and immunity in S. tuberosum. StBSL1 is shown to be a ‘susceptibility factor’ in P. infestans infection – a host protein with a positive effect on pathogen virulence. AVR2 stabilises BSL1 in planta, and both AVR2 and BSL1 are shown to suppress primary defence responses in the plant. Transcriptional analysis of brassinosteroid-treated S. tuberosum is used to identify a set of marker genes for active BR signalling. Strikingly, AVR2 is shown to upregulatethis pathway, and specifically upregulates the transcription factor StHBI1-like, identified as a suppressor of immunity. These findings reveal a novel mechanism in oomycete effector biology; the exploitation of crosstalk between the brassinosteroid pathway and immune signalling in plants.

Le puits IODP U1309D (Exp. IODP 304-305, 30°N) et le Site ODP 1275 (Leg ODP 209, 15°45'N) ont permis d'échantillonner deux core complexes océaniques de la dorsale Médio-Atlantique. Les roches récupérées sont principalement gabbroïques dont certaines très primitives et riches en olivine (ol >70%). Dans le puits U1309D, les compositions en éléments en trace des poeciloblastes de clinopyroxène et de plagioclase des roches riches en olivine indiquent qu'ils précipitent depuis le même magma dans toutes les lithologies. La composition en éléments en trace des olivines est en déséquilibre avec ces deux minéraux. Les fabriques cristallographiques de l'olivine sont faibles avec une concentration sur [001] inhabituelle, néanmoins compatibles avec une déformation plastique de haute température, avec l'activation du système de glissement (010) [100] communément décrit dans le manteau asthénosphérique. L'étude conjointe des caractéristiques géochimiques et microstructurales de ces roches met en lumière une histoire complexe de cristallisation dans un système ouvert où de larges volumes de magma de type MORB ont percolé et interagi avec le manteau appauvri superficiel. Ces roches riches en olivine représenteraient le résidu ultime de ces réactions liquide-manteau. Au site 1275, la formation des roches les plus évoluées de la série n'apparaît pas liée à l'événement d'imprégnation formant les roches riches en olivine. Ces roches correspondent à des injections tardives de magma qui ont entièrement cristallisé en profondeur sous forme de plutons intrusifs. Les résultats présentés dans ce mémoire sont compatibles avec une formation des core complexes océaniques associée à une activité magmatique relativement importante, et à une cristallisation complète de tout ou partie de ces magmas dans la lithosphère sans contre-partie volcanique en surface.

<p>Sectra Communications AB has developed a terminal for encrypted communication called the Tiger platform. During voice communication delays have sometimes been experienced resulting in conversational complications.</p><p>A solution to this problem, as was proposed by Sectra, would be to introduce voice activity detection, which means a separation of speech parts and non-speech parts of the input signal, to the Tiger platform. By only transferring the speech parts to the receiver, the bandwidth needed should be dramatically decreased. A lower bandwidth needed implies that the delays slowly should disappear. The problem is then to come up with a method that manages to distinguish the speech parts from the input signal. Fortunately a lot of theory on the subject has been done and numerous voice activity methods exist today.</p><p>In this thesis the theory of voice activity detection has been studied. A review of voice activity detectors that exist on the market today followed by an evaluation of some of these was performed in order to select a suitable candidate for the Tiger platform. This evaluation would later become the foundation for the selection of a voice activity detector for implementation.</p><p>Finally, the implementation of the chosen voice activity detector, including a comfort noise generator, was done on the platform. This implementation was based on the special requirements of the platform. Tests of the implementation in office environments show that possible delays are steadily being reduced during periods of speech inactivity, while the active speech quality is preserved.</p>

<p><b>Background and aims:</b> Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.</p><p><b>Materials and methods:</b> INS-1E cells were cultured for 5 days in 5.5, 11, 20 or 27 mM glucose in the presence or absence of AMPK-agonist AICAR. GSIS was determined from INS-1E cells and islets obtained from type 2 diabetes and control donors. Human islets and INS-1E cells were functionally characterized (GSIS) and protein profiled (SELDI-TOF MS). Glucose-induced <i>de novo</i> synthesis of fatty acyls (HR-MAS NMR spectroscopy), fatty acid composition (GC-MS), triglyceride content and specific proteins (Western blotting) were determined in INS-1E cells.</p><p><b>Results:</b> Impaired GSIS was observed from INS-1E cells exposed to chronic hyperglycaemia and islets isolated from type 2 diabetics compared to INS-1E cells cultured at normal glucose levels and control islets, respectively. Several glucose-regulated proteins were found when type 2 diabetes and control islets or mitochondria from INS-1E cells cultured at different glucose concentrations were protein profiled. Glucose induced lipid <i>de novo</i> synthesis of both saturated and unsaturated fatty acids in specific proportions. Glucose-induced impairment of function and mass was reverted by inclusion of AICAR, which lowered levels of pro-apoptotic protein CHOP but left triglyceride content unaffected.</p><p><b>Conclusions:</b> Impaired GSIS and increased apoptosis observed in β-cells after prolonged exposure to elevated glucose concentrations involved accumulation of lipid species in specific proportions, AMPK-inactivation, ER-stress activation and complex, coordinated changes in expression patterns of mitochondrial and human islet proteins.</p>

<b>Background and aims:</b> Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study. <b>Materials and methods:</b> INS-1E cells were cultured for 5 days in 5.5, 11, 20 or 27 mM glucose in the presence or absence of AMPK-agonist AICAR. GSIS was determined from INS-1E cells and islets obtained from type 2 diabetes and control donors. Human islets and INS-1E cells were functionally characterized (GSIS) and protein profiled (SELDI-TOF MS). Glucose-induced de novo synthesis of fatty acyls (HR-MAS NMR spectroscopy), fatty acid composition (GC-MS), triglyceride content and specific proteins (Western blotting) were determined in INS-1E cells. <b>Results:</b> Impaired GSIS was observed from INS-1E cells exposed to chronic hyperglycaemia and islets isolated from type 2 diabetics compared to INS-1E cells cultured at normal glucose levels and control islets, respectively. Several glucose-regulated proteins were found when type 2 diabetes and control islets or mitochondria from INS-1E cells cultured at different glucose concentrations were protein profiled. Glucose induced lipid de novo synthesis of both saturated and unsaturated fatty acids in specific proportions. Glucose-induced impairment of function and mass was reverted by inclusion of AICAR, which lowered levels of pro-apoptotic protein CHOP but left triglyceride content unaffected. <b>Conclusions:</b> Impaired GSIS and increased apoptosis observed in β-cells after prolonged exposure to elevated glucose concentrations involved accumulation of lipid species in specific proportions, AMPK-inactivation, ER-stress activation and complex, coordinated changes in expression patterns of mitochondrial and human islet proteins.

California has one highly-coveted possession: the Bay-Delta, which is the second largest estuary in the United States. Today, tensions are higher than ever as Southern California continues to grow and demand water from the Delta, agriculture suffers from drought and less-than-promised water allocations, and aquatic life diminishes due to environmentally damaging processes like pumping and exporting of water elsewhere. This paper will examine the historic policies that have shaped how the Delta has been managed, their successes and failures, and current plans in discussion for continuing improvement of the Delta. The Bay-Delta Conservation Plan and the Sacramento-San Joaquin Valley Water Reliability Act (HR 1837) are the specific current plans presented and analyzed for potential effectiveness. Despite some of the promising suggestions in HR 1837 and the Bay-Delta Conservation Plan, the Delta will remain a problem in the 21st century until stakeholders from all perspectives compromise enough to enact a single, clear-cut solution.

Sectra Communications AB has developed a terminal for encrypted communication called the Tiger platform. During voice communication delays have sometimes been experienced resulting in conversational complications. A solution to this problem, as was proposed by Sectra, would be to introduce voice activity detection, which means a separation of speech parts and non-speech parts of the input signal, to the Tiger platform. By only transferring the speech parts to the receiver, the bandwidth needed should be dramatically decreased. A lower bandwidth needed implies that the delays slowly should disappear. The problem is then to come up with a method that manages to distinguish the speech parts from the input signal. Fortunately a lot of theory on the subject has been done and numerous voice activity methods exist today. In this thesis the theory of voice activity detection has been studied. A review of voice activity detectors that exist on the market today followed by an evaluation of some of these was performed in order to select a suitable candidate for the Tiger platform. This evaluation would later become the foundation for the selection of a voice activity detector for implementation. Finally, the implementation of the chosen voice activity detector, including a comfort noise generator, was done on the platform. This implementation was based on the special requirements of the platform. Tests of the implementation in office environments show that possible delays are steadily being reduced during periods of speech inactivity, while the active speech quality is preserved.

在現今競爭激烈且日益趨向全球化的市場上，企業追求成長的壓力不斷的增加，企業若是無法持續成長，就可能隨時被市場淘汰，而併購是企業追求成長的重要方式之一，企業併購通常被認為可以帶給企業獲利、加速發展、提升市場占有率、實現規模經濟、掌握上下游資源、取得專利技術等諸多好處，但看似美好的背後往往潛藏著許多看不見的危機，嚴重的話更可能帶來併購失敗的災難性後果。而企業合併後馬上面臨許多整合問題，包含人事安排、組織改造、市場整合以及品牌定位等重要項目。跨國的企業併購更需要考量不同的國情文化、法律以及政治問題，併購成功與否的關鍵也更加複雜。 本研究欲探討的是國際併購的動機、併購整合的關鍵成功因素，有鑑於全球半導體產業已趨成熟，競爭也越來越白熱化，特別以半導體產業的國際併購為研究的主題，採用深入訪問，重視研究中的第一手資料，解析個案公司如何從併購初期評估到併購後管理的決策與執行過程，如何以尊重和執行力來重新組織被併公司的制度並保存優良的原有企業文化、增加生產力，讓併購後組織能快速提升運作效率與維持彈性，併購後資源的共享、技術及智財的交流，持續提升研發創新能力、增加員工歸屬感及信賴感都是重要的因素，巧妙融合人性化管理，才是真正戰力升級的關鍵，此個案值得作為國際企業併購決策者對於併購評估與提升經營效率之學習標竿。 / Nowadays, due to the highly competitive and gradually-globalized market, the pressure on enterprises to pursue growth increases continually. If enterprises failed to continue to grow in the market, they would be eliminated through competition. M&A (merger and acquisition), as one of the most important ways to pursue business growth, is generally thought to bring corporate profits, accelerated development, increased market share and achieve economies of scale, master upstream and downstream resources, patented technology and many other benefits. However, there are also many invisible crises that can bring enterprises catastrophic consequences. Once the M&A is decided, the enterprise will immediately face lots of issues, including personnel arrangements, reconstruction of organization, market integration and brand positioning. When it comes to cross-border M&A, the key to the success is much more complex, as the different national cultures, legal and political issues need to be considered by the enterprise at the same time. In this study, the motivation of international M&A, and the critical factors of successful merger integration were explored. In view of the global semiconductor industry has matured and the competition has become increasingly intense, the research topic was focused on the international M&A in the semiconductor industry. By using in-depth interviews as the first-hand research data, the case company’s early acquisition evaluations and post-merger management decisions were resolved in detail. In conclusion, the keys to upgrading a company’s competitiveness are how to reorganize and keep the acquired company's system and original excellent culture through a respectful way, how to quickly improve operational efficiency and increase productivity of the merged corporation without sacrificing organization flexibility, continuing to enhance research and innovation capacity by sharing and exchanging technologies and intellectual property resources, and increasing employees’ sense of belonging and trust via integrating humane management. This case is worth as an important reference to international M&A decision makers for evaluation and enhancing the operational efficiency in the future.

Introduction Le cancer bronchique est un problème de santé publique en étant la première cause de décès par cancer dans le monde. Il reste de mauvais pronostic avec une résistance au Cisplatine qui est inéluctable dans l'histoire naturelle de la maladie. Nous nous sommes intéressés à l'association du CDDP aux inhibiteurs de la Poly(ADP-ribose) polymérase. Les inhibiteurs pharmacologiques de PARP sont source d'optimisme en oncologie clinique en monothérapie pour des tumeurs déficientes pour une voie de réparation de l'ADN et en association aux cytotoxiques classiques.Matériel et méthodes Nous avons généré 9 clones résistants au CDDP après culture de la lignée A549 dans des faibles doses de CDDP. Deux inhibiteurs pharmacologiques de PARP, CEP8983 (CEP) et PJ34 (PJ), ainsi que des siRNA spécifiques de PARP1 sont utilisés pour l'inhibition de PARP. L'apoptose est mesurée en cytométrie de flux par l'intermédiaire du potentiel membranaire de la mitochondrie DiOC6(3) et la perméabilisation de la membrane plasmique est évaluée par l'iodide de propidium. Le test de clonogénicité permet d'évaluer la capacité des cellules à échapper à la mort et à former une colonie. L'activité métabolique des cellules est mesurée par la mesure de clivage du sel de tetrazolium WST-1. L'immunofluorescence sur cellules fixées a permis d'étudier les dommages de l'ADN (γH2AX), la voie intrinsèque de l'apoptose (l'activation de la caspase 3 et la libération du cytochrome c) et la recombinaison homologue (BRCA1, RAD51). En Western Blot nous avons mesuré l'expression et l'activité de PARP (PAR) ainsi que l'expression d'acteurs de la réparation par excision de base (BER) (XRCC1 and polymérase β). Nous avons développé une méthode de détection de PAR en immunohistochimie sur des tissus inclus en paraffine. Résultats Nous avons trouvé un effet synergique pour l'association du CDDP aux inhibiteurs de PARP in vitro. De façon inattendue nous avons observé que les clones résistants au CDDP développent une addiction à PARP et sont spécifiquement tués par l'inhibition de PARP contrairement à la lignée parentale. Ces clones exhibent une hyperexpression et une hyperactivité de PARP. La réponse aux inhibiteurs de PARP corrèle plus précisément avec l'activation plutôt qu'avec l'expression de PARP, pointant que PAR est un biomarqueur plus précis que PARP. Nous avons observé que l'hyperactivation de PARP accompagne une résistance induite au CDDP et prédispose à une sensibilité aux inhibiteurs de PARP dans d'autres lignées de cancer bronchique (H460 et H1650), de mésothéliome (P31), de cancer de l'ovaire (TOV112D) et de col (HeLa). Dans des expériences in vivo nous avons noté que dans les xénogreffes obtenues à partir de clones résistants au CDDP, l'expression de PAR est stablement retrouvée en immunohistochimie. Ces tumeurs répondaient à l'inhibition de PARP par le PJ en diminuant l'expression de PAR. Les clones résistants au CDDP sensibilisés aux I PARP ont une recombinaison homologue conservée, cependant ont un déficit dans les étapes terminales du BER.Conclusion Nous avons identifié un effet synergique pour l'association des inhibiteurs de PARP au CDDP de des lignées de cancer bronchique. Nous avons observé une dépendance à PARP dans des lignées de cancer bronchique résistantes au CDDP et déficientes pour l'élongation du BER. Nous postulant que PAR est un biomarqueur spécifique de la réponse aux inhibiteurs de PARP.