The effect of increased egg consumption on plasma cholesterol levels and its distribution among lipoproteins and Apolipoprotein A-I/A-II ratios of high density lipoprotein subfractions in individuals who did and did not demonstrate response in plasma cholesterol levels was studied in 20 healthy middle-aged men (30-55 years of age) for three months. Lunch containing 3 eggs was fed all subjects during the first month classification period. Subsequently, subjects were divided into hyper and hyporesponders according to their blood cholesterol level. Thereafter, 6 eggs were fed to hypo (n=12) while hyper (n=8) continued to consume 3 eggs with lunch. The average plasma cholesterol level of the 20 subjects was increased from 185±34 to 195±34 mg/lOOml during the classification period. The mean plasma cholesterol level of the hyperresponders was significantly (p<0.025) increased from 170±42 to 199±40 mg/100ml during classification while that of the hyporesponders fell slightly. The additional 6 eggs consumed by the hyporesponders for 6 weeks did not increase the mean plasma cholesterol level. The apoprotein ratios did not change as a result of the increased cholesterol diet and were not significantly different between the two response groups. The hyper and hyporesponders differed significantly in initial plasma cholesterol parameters that diminished as the subjects were challenged with increased cholesterol consumption. These initial differences included a significantly lower low density lipoprotein cholesterol/high density lipoprotein cholesterol ratio of 2.26±0.6 for hyperresponders compared to 3.31±0.9 for hyporesponders. There were also initial differences in the percentage of whole plasma cholesterol found in the HDL fractions: hyperresponders had a greater percentage of total and free cholesterol in the HDL and HDL-2 fractions and a greater percentage of total cholesterol in the HDL-3 fraction. The present data demonstrate that increased cholesterol consumption will increase plasma cholesterol levels and that there is individual variability of plasma cholesterol response as a result of feeding cholesterol. / Graduation date: 1984

Thesis (M.S.)--Ohio State University, 2009. / Title from first page of PDF file. Includes vita. Includes bibliographical references (p. 102-114).

Part of Thesis--University of Chicago, 1936. / Lithoprinted. "Private edition, distributed by the University of Chicago libraries, Chicago, Illinois." Bibliography: p. 18-19.

Part of Thesis--University of Chicago, 1936. / Lithoprinted. "Private edition, distributed by the University of Chicago libraries, Chicago, Illinois." Bibliography: p. 18-19.

Photocopy of typescript. / Digitized by Kansas Correctional Industries

Two studies which were similar in protocol were conducted. Following a preliminary baseline period of 7 days, in which the subjects consumed their self-chosen diets, they received 3 eggs daily for 4 weeks. Depending upon the changes in plasma cholesterol in response to 3 eggs daily, the subjects in studies A and B were divided into 2 groups. During the subsequent 4 week treatment period, the hyporesponders received 6 eggs daily in study A, and 3 eggs and additional butter daily in study B. The hyperresponders consumed 3 eggs daily in study A; and 3 eggs with additional high PUFA margarine in study B. Dietary records were taken during the last 7 days of each period. A total of 128 seven-day dietary records kept by these subjects indicated that the majority of them met the RDA's for the nutrients studied, except vitamin B6 and folacin. Vitamin B6 intakes were below 67% of the RDA in 13% of the diets, and were below 67% of the RDA for folacin in 21% of the diets. There was a problem in meeting 67% of the RDA for zinc in subjects who consumed less than 70 g. of protein daily. When the subjects added 3 whole eggs daily to their self-chosen diets, there were significant increases in protein (p<0.05), total fat (p<0.01), phosphorous (p<0.01), sodium (p<0.001), iron (p<0.05), and dietary cholesterol (p<0.0001). A significant decrease in non-egg dietary cholesterol (p<0.01) was also observed. There were no significant differences in nutrient intake between hypos and hypers in either the baseline or classification periods. No further changes in nutrient intakes were seen in the 9 subjects who continued consuming 3 added eggs daily during treatment period. The 13 hyporesponders who added 6 eggs daily to their self-chosen diets had significant increases, compared to baseline, in protein (p<0.05), total fat (p<0.05), and dietary cholesterol (p<0.0001) and significant decreases in carbohydrate (p<0.01), thiamin (p<0.05), and vitamin B6 (p<0.05). Other than obvious increases in total fat, no other changes in nutrient intake were observed upon the addition of butter or margarine. The use of nutritional supplements was observed in 71% of the subjects: 58% regularly and 13% occasionally. All subjects who took supplements included vitamin C. In general, nutrient supplements did not improve poor nutrient intakes. These results show overall adequacy of the diets for most of the men, which is consistent with other studies. The effects of additional egg in the diet were increases in protein, fat and cholesterol intakes and a decrease in carbohydrate consumption. / Graduation date: 1985

Thesis (Ph. D.)--Washington State University, May 2006. / Includes bibliographical references (p. 180-185).

Thesis (M.S.)--West Virginia University, 2009. / Title from document title page. Document formatted into pages; contains viii, 51 p. : ill. Includes abstract. Includes bibliographical references.