Thesis (M.S.)--Wisconsin. / Includes bibliographical references (leaf 30).

The effect of, unidirectional static stress on the electrode potential of copper was studied. Studies were made with both soft copper and cold drawn copper in solutions of copper sulphate and several other electrolytes. The change in magnitude of the electrode potential was found to depend on several variables, time, temperature, stress per unit area, concentration of solution and the electrolyte in solution. Measurement, which was made in most instances with a Leeds and Northrup potentiometer, was between stressed and unstressed pairs of copper wire. Stress was applied by attaching a scale pan to one of the wires and applying weights to the pan. Two main conclusions can be drawn from the results obtained. (1) Strain potential is the result of two separate effects. The first effect, that of the rupture of a surface film is the dominant effect, but the second effect that of the change in internal energy due to plastic deformation cannot be discarded. (2) Strain potential cannot be ignored as a factor in corrosion problems. It has been shown that a stress of 992 kgm/cm² can cause a potential change in the more anodic or active direction of over 50 mv. If stress is applied to a non-homogeneous metal system some portions of the system will be under plastic strain while others will possibly be under plastic strain. The plastic strain areas, which would usually be situated at grain boundaries, would therefore be more active and highly susceptible to corrosion. Failure of the metal could then be caused by stress concentration or by the gradual corrosion of the grain boundaries of the metal system. / Science, Faculty of / Chemistry, Department of / Graduate

Thesis (Ph. D.)--University of Adelaide, 1985. / Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1958. / Typescript. Vita. "Part I. Analytical applications of the hanging mercury drop electrode ... the text of a paper by J.W. Ross, Jr., R.D. DeMars, and Irving Shain which was published in Analytical Chemistry, 28, 1768 (1956)." eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Magister Scientiae - MSc / An amperometric biosensor was prepared by in situ deposition of cytochrome P4502D6 (CYP2D6, P4502D6) enzyme on a polyaniline (PANI)-doped glassy carbon electrode. The PANI film was electrochemically deposited on the electrode at 100 mV s-1 against Ag/AgCl. Cyclic voltammetric characterisation of the PANI film in 1 M HCl solution showed two distinct redox peaks, which prove that the PANI film was electroactive and exhibited fast reversible electrochemistry. The surface concentration and film thickness of the adsorbed electroactive species was estimated to be 1.85 x 10 -7 mol cm -2 and approximately 16 nm, respectively. Cytochrome P4502D6 was electrostatically immobilised onto the surface of the PANI film and cyclic voltammetry was used to monitor the serotonin reuptake inhibitors (fluoxetine, fluvoxamine and citalopram) in phosphate buffer solution. Fluoxetine was found to be a substrate of CYP2D6 at low concentrations but inhibits enzyme activity at high concentrations; this was consistent with uncompetitive substrate inhibition kinetics. Thus PANI-mediated electrochemistry can be used to observe monooxygenation reaction of CYP2D6. / South Africa

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