<p>Akrilamid je supstanca koja se prirodno stvara pečenjem i prženjem hrane bogate skrobom.&nbsp; Cilj rada je bio da se ispita subhronični i akutni uticaj akrilamida na debelo&nbsp;crevo prepubertalnih pacova. Dobijeni rezultati su pokazali da akrilamid ne naru&scaron;ava morfologiju zida creva, ali dovodi do promena u volumenskoj gustini njegovih tunika i lamina. Najizraženije promene&nbsp; su bile na&nbsp; vezivnom tkivu&nbsp; debelog creva.&nbsp; Analizom peharastih ćelija&nbsp; i sadržaja mucina pokazano je da akrilamid utiče i na ugljenohidratnu i na proteinsku komponentu mucina. Subhronični tretman je&nbsp; doveo do smanjenja broja&nbsp;limfocita i&nbsp; eozinofila, a&nbsp; kod akutnog tretmana&nbsp; je primećeno nakupljanje limfocita i eozinofila u kolonu akrilamidom tretiranih jedinki. Broj mastocita je u sva tri eksperimenta bio smanjen kod tretiranih životinja. Duže izlaganje akrilamidu ima imunosupresivno dejstvo kod pacova.</p> / <p>Acrylamide is natural product of cooking (baking, roasting) starchy food.&nbsp; Aim of the study was to evaluate the risk of subchronic and acute acrylamide treatment on juvenile&nbsp; rat colon.&nbsp; Changes&nbsp; in colon wall morphology was detected by stereological methods since histological evaluation reveal normal colon architecture&nbsp; after acrylamide intoxication.&nbsp; The changes was&nbsp; most prominent on&nbsp; connective tissue of rat colon.&nbsp; Acrylamide affected both protein&nbsp; component of mucins and glycans linked to peptide backbone.&nbsp; In subchronic&nbsp; treatment acrylamide caused reduction of lymphocytes&nbsp; and eosinophils &nbsp;number, while acute experiment lead to lymphocytes&nbsp; and&nbsp; eosinophils&nbsp; accumulation in colon tissue. Acrylamide intoxication decreased mast cell number in all experiments. Longer acrylamide exposure had immunosuppressive effect in rats.</p>