Assessment of water quality within the Escatawpa River system was accomplished utilizing the Better Assessment Science Integrating Point and Nonpoint Sources (BASINS 2.0) to develop the watershed model, and the CE-QUAL-W2 software to develop the estuary model. The watershed model was utilized to quantify both hydrodynamic and water quality (fecal coliforms) characteristics of the watershed for a simulation period spanning from 1990 through 1999. Herein, calibration and application results are presented for watershed and estuary simulations made in an uncoupled manner. The models were developed such that loose coupling of watershed and estuary models can be accomplished as a subsequent phase of this ongoing project. CE-QUAL-W2 model calibration was performed utilizing a set of site specific data acquired on the Escatawpa Estuary System during an intensive survey period of September 10-15, 1997. Dissolved oxygen levels in the system were closely examined, with regards to the impacts from point source discharges.