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Nádorová imunoterapie založená na synergii agonistů TLR a ligandů stimulujících fagocytózu. Posouzení spoluúčasti získané imunity.PAĎOUKOVÁ, Lucie January 2018 (has links)
The aim of this thesis is to improve the therapeutic effect of the immunotherapy based on the synergy of TLR agonists with phagocytosis stimulating ligands. Furthermore, this thesis is focused on the information transfer to the specific immunity, as well as it pursues the study of the specific immunity relevance during cancer immunotherapy.
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Nádorová imunoterapie založená na mechanismech vrozené imunity a studium možnosti zvýšení její účinnosti úpravou nádorového prostředíMASÁKOVÁ, Kamila January 2018 (has links)
The aim of this thesis was to study how to increase effectiveness of cancer immunotherapy based on synergy of compounds stimulating phagocytosis and TLR agonist. Tumor microenvironment was modified by enzymes, which catalised conversion of lactate to pyruvate or acetate. It was monitored effect of enzymes on tumor size, survival of experimental mice and cytotoxicity on tumor cells.
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